Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OPHN1
  • Mouse genes Ophn1
  • Rat genes Ophn1
  • Zfish genes ophn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ophn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Ophn1	IDA		Mouse	PMID:12932438
Molecular Function	GO:0005096	GTPase activator activity	Ophn1	IMP		Mouse	PMID:19481455
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Ophn1	IPI	RGD:621531	Rat	PMID:19487570|RGD:4107729
Molecular Function	GO:0005543	phospholipid binding	OPHN1	IDA		Human	PMID:18954304
Molecular Function	GO:0005515	protein binding	Ophn1	IPI	UniProtKB:P20393|UniProtKB:Q3UV55	Mouse	MGI:MGI:5303043|PMID:21874017
Molecular Function	GO:0005515	protein binding	Ophn1	IPI	PR:Q62420	Mouse	PMID:19481455
Molecular Function	GO:0005515	protein binding	Ophn1	IPI	PR:P39053	Mouse	PMID:19481455
Molecular Function	GO:0005515	protein binding	Ophn1	IPI	UniProtKB:Q63503	Rat	PMID:21874017|RGD:8554394
Cellular Component	GO:0015629	actin cytoskeleton	Ophn1	IDA		Mouse	PMID:12932438
Cellular Component	GO:0005737	cytoplasm	Ophn1	IDA		Mouse	MGI:MGI:5303043|PMID:21874017
Cellular Component	GO:0030425	dendrite	Ophn1	IDA		Mouse	MGI:MGI:5303043|PMID:21874017
Cellular Component	GO:0043197	dendritic spine	Ophn1	IDA		Mouse	MGI:MGI:5303043|PMID:21874017
Cellular Component	GO:0098978	glutamatergic synapse	OPHN1	EXP		Human	PMID:24966368
Cellular Component	GO:0098978	glutamatergic synapse	OPHN1	IDA		Human	PMID:24966368
Cellular Component	GO:0098978	glutamatergic synapse	OPHN1	IMP		Human	PMID:24966368
Cellular Component	GO:0098978	glutamatergic synapse	Ophn1	EXP		Rat	PMID:24966368|RGD:13702374
Cellular Component	GO:0098978	glutamatergic synapse	Ophn1	IDA		Rat	PMID:24966368|RGD:13702374
Cellular Component	GO:0098978	glutamatergic synapse	Ophn1	IMP		Rat	PMID:24966368|RGD:13702374
Cellular Component	GO:0098793	presynapse	Ophn1	IDA		Rat	PMID:15034583|RGD:12914793
Cellular Component	GO:0043195	terminal bouton	Ophn1	IDA		Mouse	PMID:19481455
Biological Process	GO:0030036	actin cytoskeleton organization	Ophn1	IDA		Mouse	PMID:12932438
Biological Process	GO:0034329	cell junction assembly	OPHN1	IMP		Human	PMID:22891260
Biological Process	GO:0048667	cell morphogenesis involved in neuron differentiation	OPHN1	IMP		Human	PMID:27160703
Biological Process	GO:0021707	cerebellar granule cell differentiation	OPHN1	IMP		Human	PMID:27160703
Biological Process	GO:0021895	cerebral cortex neuron differentiation	OPHN1	IMP		Human	PMID:27160703
Biological Process	GO:0045198	establishment of epithelial cell apical/basal polarity	OPHN1	IMP		Human	PMID:22891260
Biological Process	GO:0098880	maintenance of postsynaptic specialization structure	Ophn1	EXP		Rat	PMID:24966368|RGD:13702374
Biological Process	GO:0098880	maintenance of postsynaptic specialization structure	Ophn1	IDA		Rat	PMID:24966368|RGD:13702374
Biological Process	GO:0098880	maintenance of postsynaptic specialization structure	Ophn1	IMP		Rat	PMID:24966368|RGD:13702374
Biological Process	GO:1901799	negative regulation of proteasomal protein catabolic process	Ophn1	IDA		Mouse	MGI:MGI:5303043|PMID:21874017
Biological Process	GO:0030182	neuron differentiation	OPHN1	IMP		Human	PMID:27160703
Biological Process	GO:0031175	neuron projection development	OPHN1	IMP		Human	PMID:27160703
Biological Process	GO:0030100	regulation of endocytosis	Ophn1	IMP		Mouse	PMID:19481455
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	OPHN1	EXP		Human	PMID:24966368
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	OPHN1	IDA		Human	PMID:24966368
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	OPHN1	IMP		Human	PMID:24966368
Biological Process	GO:0035023	regulation of Rho protein signal transduction	OPHN1	IMP		Human	PMID:27160703
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	Ophn1	IMP		Mouse	PMID:19481455
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Ophn1	IDA		Rat	PMID:19481455|RGD:155230799
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Ophn1	IMP		Rat	PMID:19481455|RGD:155230799
Biological Process	GO:0048488	synaptic vesicle endocytosis	Ophn1	IGI	MGI:MGI:700009	Mouse	PMID:19481455
Biological Process	GO:0048488	synaptic vesicle endocytosis	Ophn1	IMP		Mouse	PMID:19481455

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern