Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OPRD1
  • Mouse genes Oprd1
  • Rat genes Oprd1
  • Zfish genes oprd1a,oprd1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Oprd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0038046	G protein-coupled enkephalin receptor activity	OPRD1	IMP		Human	PMID:9548483
Molecular Function	GO:0038046	G protein-coupled enkephalin receptor activity	Oprd1	IDA		Rat	PMID:7519274|RGD:2316599
Molecular Function	GO:0038046	G protein-coupled enkephalin receptor activity	oprd1b	IDA		Zfish	PMID:17170080
Molecular Function	GO:0038046	G protein-coupled enkephalin receptor activity	oprd1b	IDA		Zfish	PMID:18022288
Molecular Function	GO:0038046	G protein-coupled enkephalin receptor activity	oprd1b	IDA		Zfish	PMID:28284867
Molecular Function	GO:0038046	G protein-coupled enkephalin receptor activity	oprd1a	IDA		Zfish	PMID:28284867
Molecular Function	GO:0038046	G protein-coupled enkephalin receptor activity	oprd1a	IDA		Zfish	PMID:18022288
Molecular Function	GO:0004985	G protein-coupled opioid receptor activity	OPRD1	IDA		Human	PMID:22184124
Molecular Function	GO:0004985	G protein-coupled opioid receptor activity	Oprd1	IMP	MGI:MGI:2387013	Mouse	PMID:12113946
Molecular Function	GO:0004985	G protein-coupled opioid receptor activity	Oprd1	IDA		Mouse	PMID:8738226
Molecular Function	GO:0004985	G protein-coupled opioid receptor activity	Oprd1	IDA		Mouse	PMID:8393575
Molecular Function	GO:0038047	morphine receptor activity	oprd1b	IDA		Zfish	PMID:28284867
Molecular Function	GO:0005515	protein binding	OPRD1	IPI	UniProtKB:Q5JY77	Human	PMID:15086532
Molecular Function	GO:0005515	protein binding	OPRD1	IPI	UniProtKB:P11607	Human	PMID:20528919
Molecular Function	GO:0005515	protein binding	OPRD1	IPI	UniProtKB:P16615	Human	PMID:20528919
Molecular Function	GO:0005515	protein binding	OPRD1	IPI	UniProtKB:P27824	Human	PMID:20528919
Molecular Function	GO:0005515	protein binding	OPRD1	IPI	UniProtKB:Q0VAQ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPRD1	IPI	UniProtKB:Q4LDR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPRD1	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPRD1	IPI	UniProtKB:Q9NS64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPRD1	IPI	UniProtKB:Q9UKG4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPRD1	IPI	UniProtKB:Q9Y666-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Oprd1	IPI	UniProtKB:Q9ER80	Mouse	MGI:MGI:6092990|PMID:18836069
Molecular Function	GO:0033612	receptor serine/threonine kinase binding	Oprd1	IPI	RGD:2062	Rat	PMID:28381559|RGD:13513978
Cellular Component	GO:0043679	axon terminus	Oprd1	IDA		Rat	PMID:9183814|RGD:2316596
Cellular Component	GO:0005737	cytoplasm	Oprd1	IDA		Rat	PMID:16192372|RGD:2316584
Cellular Component	GO:0032590	dendrite membrane	Oprd1	IDA		Rat	PMID:9183814|RGD:2316596
Cellular Component	GO:0016020	membrane	Oprd1	IDA		Mouse	PMID:8738226
Cellular Component	GO:0016020	membrane	Oprd1	IDA		Mouse	PMID:8393575
Cellular Component	GO:0045121	membrane raft	Oprd1	IDA		Rat	PMID:17141202|RGD:2316583
Cellular Component	GO:0098992	neuronal dense core vesicle	Oprd1	IDA		Mouse	PMID:21321602
Cellular Component	GO:0098992	neuronal dense core vesicle	Oprd1	EXP		Mouse	PMID:21321602
Cellular Component	GO:0098992	neuronal dense core vesicle	Oprd1	IDA		Rat	PMID:7666182|RGD:13702250
Cellular Component	GO:0005886	plasma membrane	OPRD1	IDA		Human	PMID:22184124
Cellular Component	GO:0005886	plasma membrane	Oprd1	IDA		Rat	PMID:16192372|RGD:2316584
Cellular Component	GO:0005886	plasma membrane	oprd1b	IDA		Zfish	PMID:28284867
Cellular Component	GO:0005886	plasma membrane	oprd1a	IDA		Zfish	PMID:28284867
Cellular Component	GO:0098839	postsynaptic density membrane	Oprd1	IDA		Rat	PMID:11312309|RGD:13702315
Cellular Component	GO:0045211	postsynaptic membrane	Oprd1	IDA		Rat	PMID:9183814|RGD:2316596
Cellular Component	GO:0042734	presynaptic membrane	Oprd1	IDA		Rat	PMID:7666182|RGD:13702250
Cellular Component	GO:0097444	spine apparatus	Oprd1	IDA		Rat	PMID:11312309|RGD:13702315
Cellular Component	GO:0030672	synaptic vesicle membrane	Oprd1	IDA		Rat	PMID:7666182|RGD:13702250
Cellular Component	GO:0031982	vesicle	Oprd1	IDA		Rat	PMID:9183814|RGD:2316596
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Oprd1	IDA		Mouse	PMID:8738226
Biological Process	GO:0008344	adult locomotory behavior	Oprd1	IMP	MGI:MGI:2387013	Mouse	PMID:10835636
Biological Process	GO:0071363	cellular response to growth factor stimulus	Oprd1	IEP		Rat	PMID:7562535|RGD:2316598
Biological Process	GO:0071456	cellular response to hypoxia	OPRD1	IDA		Human	PMID:24613828
Biological Process	GO:0097237	cellular response to toxic substance	OPRD1	IDA		Human	PMID:24613828
Biological Process	GO:0042755	eating behavior	Oprd1	IMP		Rat	PMID:15949635|RGD:9831409
Biological Process	GO:0038003	G protein-coupled opioid receptor signaling pathway	OPRD1	IMP		Human	PMID:9548483
Biological Process	GO:0038003	G protein-coupled opioid receptor signaling pathway	oprd1b	IDA		Zfish	PMID:28284867|ZFIN:ZDB-PUB-170313-3
Biological Process	GO:0038003	G protein-coupled opioid receptor signaling pathway	oprd1b	IDA		Zfish	PMID:17170080
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	OPRD1	IDA		Human	PMID:16325578
Biological Process	GO:0010629	negative regulation of gene expression	OPRD1	IDA		Human	PMID:24613828
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	OPRD1	IDA		Human	PMID:24613828
Biological Process	GO:0007218	neuropeptide signaling pathway	Oprd1	IDA		Mouse	PMID:8393575
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Oprd1	IDA		Rat	PMID:9572309|RGD:8553369
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	OPRD1	IDA		Human	PMID:24613828
Biological Process	GO:0051924	regulation of calcium ion transport	Oprd1	IMP		Rat	PMID:10493735|RGD:2316594
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	OPRD1	IDA		Human	PMID:24613828
Biological Process	GO:0051930	regulation of sensory perception of pain	Oprd1	IDA		Rat	PMID:10908631|RGD:9831416
Biological Process	GO:0051930	regulation of sensory perception of pain	Oprd1	IDA		Rat	PMID:12710986|RGD:2316589

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern