Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OPRL1
  • Mouse genes Oprl1
  • Rat genes Oprl1
  • Zfish genes oprl1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Oprl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	OPRL1	IPI	UniProtKB:P30678	Human	PMID:10571060
Molecular Function	GO:0004930	G protein-coupled receptor activity	OPRL1	IPI	UniProtKB:P30679	Human	PMID:10571060
Molecular Function	GO:0004930	G protein-coupled receptor activity	OPRL1	IPI	UniProtKB:Q9TU29	Human	PMID:10571060
Molecular Function	GO:0004930	G protein-coupled receptor activity	OPRL1	IMP		Human	PMID:8137918
Molecular Function	GO:0042923	neuropeptide binding	oprl1	IDA		Zfish	PMID:21773621
Molecular Function	GO:0001626	nociceptin receptor activity	OPRL1	IDA		Human	PMID:10571060
Molecular Function	GO:0001626	nociceptin receptor activity	OPRL1	IDA		Human	PMID:12568343
Molecular Function	GO:0001626	nociceptin receptor activity	Oprl1	IMP		Mouse	MGI:MGI:3607882|PMID:12217419
Molecular Function	GO:0001626	nociceptin receptor activity	oprl1	IDA		Zfish	PMID:21247980
Molecular Function	GO:0005515	protein binding	OPRL1	IPI	UniProtKB:Q13519:PRO_0000008327	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	OPRL1	IPI	UniProtKB:Q6ZMG9	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	Oprl1	IPI	RGD:3234	Rat	PMID:15748148|RGD:9835006
Cellular Component	GO:0016020	membrane	Oprl1	IDA		Rat	PMID:20237332|RGD:9835012
Cellular Component	GO:0005886	plasma membrane	OPRL1	IDA		Human	PMID:12568343
Cellular Component	GO:0005886	plasma membrane	OPRL1	IDA		Human	PMID:8137918
Cellular Component	GO:0005886	plasma membrane	oprl1	IDA		Zfish	PMID:21773621
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	OPRL1	IMP		Human	PMID:12568343
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	OPRL1	IMP		Human	PMID:8137918
Biological Process	GO:1990708	conditioned place preference	Oprl1	IMP		Rat	PMID:21095077|RGD:14348962
Biological Process	GO:0042755	eating behavior	Oprl1	IMP		Rat	PMID:11961051|RGD:9831406
Biological Process	GO:0044849	estrous cycle	Oprl1	IEP		Rat	PMID:12710984|RGD:9835032
Biological Process	GO:0038003	G protein-coupled opioid receptor signaling pathway	OPRL1	IDA		Human	PMID:10571060
Biological Process	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Oprl1	IDA		Rat	PMID:15748148|RGD:9835006
Biological Process	GO:0045776	negative regulation of blood pressure	Oprl1	IMP		Rat	PMID:10651151|RGD:9835014
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	Oprl1	IMP		Rat	PMID:16019191|RGD:9835005
Biological Process	GO:1901386	negative regulation of voltage-gated calcium channel activity	Oprl1	IMP		Rat	PMID:15937148|RGD:9835002
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	OPRL1	IPI	UniProtKB:P30678	Human	PMID:10571060
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	OPRL1	IPI	UniProtKB:P30679	Human	PMID:10571060
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	OPRL1	IPI	UniProtKB:Q9TU29	Human	PMID:10571060
Biological Process	GO:0060454	positive regulation of gastric acid secretion	Oprl1	IMP		Rat	PMID:12007927|RGD:9835018
Biological Process	GO:1904058	positive regulation of sensory perception of pain	Oprl1	IMP		Rat	PMID:17167094|RGD:9850140
Biological Process	GO:0035810	positive regulation of urine volume	Oprl1	IDA		Rat	PMID:15010357|RGD:9835013
Biological Process	GO:1904059	regulation of locomotor rhythm	Oprl1	IMP		Rat	PMID:16310969|RGD:9835023
Biological Process	GO:0051930	regulation of sensory perception of pain	Oprl1	IMP		Rat	PMID:16565164|RGD:9835003
Biological Process	GO:0032355	response to estradiol	Oprl1	IEP		Rat	PMID:12710984|RGD:9835032
Biological Process	GO:0019233	sensory perception of pain	Oprl1	IMP		Mouse	MGI:MGI:3607882|PMID:12217419

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern