Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OPTN
  • Mouse genes Optn
  • Rat genes Optn
  • Zfish genes optn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Optn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	OPTN	IPI	UniProtKB:Q96CV9	Human	PMID:23414517
Molecular Function	GO:0042802	identical protein binding	OPTN	IPI	UniProtKB:Q96CV9	Human	PMID:24983867
Molecular Function	GO:0042802	identical protein binding	OPTN	IPI	UniProtKB:Q96CV9	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	OPTN	IPI	UniProtKB:Q96CV9	Human	PMID:25910212
Molecular Function	GO:0042802	identical protein binding	OPTN	IPI	UniProtKB:Q96CV9	Human	PMID:26871637
Molecular Function	GO:0042802	identical protein binding	OPTN	IPI	UniProtKB:Q96CV9	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	Optn	IPI	RGD:628886	Rat	PMID:20161783|RGD:6480515
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	Optn	IDA		Mouse	PMID:17702576
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	OPTN	IDA		Human	PMID:21617041
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P61006	Human	PMID:15837803
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9I8D1	Human	PMID:15837803
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UM54	Human	PMID:15837803
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9HA65	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y3C0	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P61006	Human	PMID:17646400
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q92930	Human	PMID:17646400
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UHD2	Human	PMID:18307994
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q29122	Human	PMID:19805065
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q13114	Human	PMID:20174559
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UHD2	Human	PMID:20174559
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96NC0	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P61006	Human	PMID:20388642
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15025	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8N448	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UJX2	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y3C0	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O95166	Human	PMID:21617041
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P38182	Human	PMID:21617041
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P60520	Human	PMID:21617041
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9GZQ8	Human	PMID:21617041
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9H0R8	Human	PMID:21617041
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9H492	Human	PMID:21617041
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q00013	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UHD2	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15025	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P61006	Human	PMID:22854040
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9HA65	Human	PMID:22854040
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P42858	Human	PMID:23275563
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15025	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BUY5	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UHD2	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P54845-1	Human	PMID:23956131
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q99IB8:PRO_0000045599	Human	PMID:24136289
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q13501	Human	PMID:25026213
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8IYU2	Human	PMID:25026213
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P61026	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15025	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15038	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q86UD4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8TC07	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8TD17	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BS34	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UJX2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y3C0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UHD2	Human	PMID:25803835
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15025	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9NTZ6	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UJX2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y3C0	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15025	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y3C0	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UHD2	Human	PMID:27086836
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8N448	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15025	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15025	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8N448	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y3C0	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O00560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O75604	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P17021	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q12904-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15025	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15038	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8IYE1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8TC07	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96B67	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BS34	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BUY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9NTZ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9NWF9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y3C0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UHD2	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:A0A1C3PI11	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:A1A4Y4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:A2RRN7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:A2RU56	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:A4FUJ8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:I6L9D0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O00203	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O15195-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O15392	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O43829	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O60711	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O60927	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O95340	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O95671	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:O95872	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P04440	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P07225	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P07384	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P08758	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P10074	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P10276-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P15169	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P17029	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P18206-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P23297	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P23528	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P24666-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P26639	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P28347-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P28566	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P35998	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P49450	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P49459	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P50749	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P51116	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P51582	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P51608	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P52306-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P52888	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P54274-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P55058-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P61296-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:P78410	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q02556	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q08499-8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q0P5N6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q0P5P2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q13113	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q13123	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q13573	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q13586	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q13702-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q14847-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q14894	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q15797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q2NKQ1-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q32M92-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q3KNW7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q3SX64	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q496A3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q49A26-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q53HV7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q5TZF3-1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q5VYS8-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q5VZL5-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q6IE81-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q6NXG1-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q6PCB6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q6XD76	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q6YHU6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q6ZNA4-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q6ZS81-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q71DI3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q86TI2-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q86VR2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8IV33	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8IVL6-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8IXS6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8IZQ1-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8IZS5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8N0Y2-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8N1C3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8N1Y9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8N205-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8N302-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8N5A5-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8TBB0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8TBE1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8TC07	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8TDB4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8WVJ2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q8WXF7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q92185	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q969S8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96EF9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96EY8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96EZ4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96G46	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96G97-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96GM5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96HQ0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96LL4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96LX8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96MN9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96NC0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96PU8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96QE2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q96RQ9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q99732	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q99942	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BUB5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BUH6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BUH8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BUL9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BV73	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BWG1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BYQ4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9BYZ2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9C0D3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9H6R3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9HBL8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9NR11-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9NRA0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9NSI6-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9NWS9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9NY26	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9P209	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9P2R7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UBT3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UDX5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UIR0-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9ULX5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9UQ53	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y221	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y2X9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y574-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y5L3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y5Y5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	OPTN	IPI	UniProtKB:Q9Y6Q9-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Optn	IPI	PR:O35245	Mouse	PMID:15607428
Molecular Function	GO:0005515	protein binding	Optn	IPI	PR:Q60855	Mouse	PMID:17702576
Molecular Function	GO:0005515	protein binding	Optn	IPI	PR:P25118	Mouse	PMID:17702576
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	OPTN	IPI	UniProtKB:Q9UHD2	Human	PMID:25803835
Molecular Function	GO:0001155	TFIIIA-class transcription factor binding	Optn	IPI	RGD:619746	Rat	PMID:10756201|RGD:6480517
Molecular Function	GO:0043130	ubiquitin binding	Optn	IDA		Rat	PMID:21059646|RGD:7775023
Cellular Component	GO:0030424	axon	Optn	IDA		Rat	PMID:28761318|RGD:13432138
Cellular Component	GO:0005737	cytoplasm	Optn	IDA		Rat	PMID:21059646|RGD:7775023
Cellular Component	GO:0031410	cytoplasmic vesicle	Optn	IDA		Rat	PMID:15837803|RGD:8554668
Cellular Component	GO:0031410	cytoplasmic vesicle	Optn	IDA		Rat	PMID:21896272|RGD:7775054
Cellular Component	GO:0005829	cytosol	OPTN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	OPTN	IDA		Human	PMID:15837803
Cellular Component	GO:0005794	Golgi apparatus	OPTN	IDA		Human	PMID:27534431
Cellular Component	GO:0005794	Golgi apparatus	Optn	IDA		Rat	PMID:20161783|RGD:6480515
Cellular Component	GO:0005794	Golgi apparatus	Optn	IDA		Rat	PMID:15837803|RGD:8554668
Cellular Component	GO:0043025	neuronal cell body	Optn	IDA		Rat	PMID:28761318|RGD:13432138
Cellular Component	GO:0005634	nucleus	Optn	IDA		Rat	PMID:28776281|RGD:13432574
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Optn	IDA		Mouse	PMID:15607428
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Optn	IDA		Rat	PMID:28776281|RGD:13432574
Cellular Component	GO:0005802	trans-Golgi network	OPTN	IDA		Human	PMID:20174559
Biological Process	GO:0007409	axonogenesis	optn	IMP	ZFIN:ZDB-MRPHLNO-130520-2	Zfish	PMID:23178947
Biological Process	GO:0007409	axonogenesis	optn	IMP	ZFIN:ZDB-MRPHLNO-130520-1	Zfish	PMID:23178947
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Optn	IEP		Rat	PMID:28776281|RGD:13432574
Biological Process	GO:1905232	cellular response to L-glutamate	Optn	IEP		Rat	PMID:28761318|RGD:13432138
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Optn	IEP		Rat	PMID:17663725|RGD:7401258
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Optn	IEP		Rat	PMID:28776281|RGD:13432574
Biological Process	GO:0034620	cellular response to unfolded protein	OPTN	IMP		Human	PMID:27534431
Biological Process	GO:0042742	defense response to bacterium	optn	IMP	ZFIN:ZDB-MRPHLNO-151125-2	Zfish	PMID:30818338
Biological Process	GO:0042742	defense response to bacterium	optn	IMP	ZFIN:ZDB-GENO-200324-8	Zfish	PMID:30818338
Biological Process	GO:0050829	defense response to Gram-negative bacterium	OPTN	IMP		Human	PMID:21617041
Biological Process	GO:0007030	Golgi organization	OPTN	IMP		Human	PMID:15837803
Biological Process	GO:0007030	Golgi organization	Optn	IMP		Rat	PMID:15837803|RGD:8554668
Biological Process	GO:0007030	Golgi organization	Optn	IMP		Rat	PMID:21896272|RGD:7775054
Biological Process	GO:0090161	Golgi ribbon formation	OPTN	IDA		Human	PMID:15837803
Biological Process	GO:0090161	Golgi ribbon formation	OPTN	IMP		Human	PMID:27534431
Biological Process	GO:0043001	Golgi to plasma membrane protein transport	OPTN	IMP		Human	PMID:15837803
Biological Process	GO:0008285	negative regulation of cell population proliferation	Optn	IMP		Rat	PMID:28776281|RGD:13432574
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Optn	IMP		Mouse	PMID:17702576
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Optn	IMP		Rat	PMID:22194658|RGD:7775021
Biological Process	GO:0001920	negative regulation of receptor recycling	OPTN	IMP		Human	PMID:22854040
Biological Process	GO:0003407	neural retina development	Optn	IEP		Rat	PMID:17687037|RGD:7800681
Biological Process	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	OPTN	IMP		Human	PMID:25294927
Biological Process	GO:0010508	positive regulation of autophagy	OPTN	IDA		Human	PMID:21617041
Biological Process	GO:0008284	positive regulation of cell population proliferation	Optn	IMP		Rat	PMID:22194658|RGD:7775021
Biological Process	GO:0001819	positive regulation of cytokine production	Optn	IMP		Rat	PMID:28776281|RGD:13432574
Biological Process	GO:0010628	positive regulation of gene expression	Optn	IMP		Rat	PMID:22194658|RGD:7775021
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Optn	IMP		Rat	PMID:22194658|RGD:7775021
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Optn	IMP		Rat	PMID:25385380|RGD:13434903
Biological Process	GO:1904417	positive regulation of xenophagy	OPTN	IMP		Human	PMID:21617041
Biological Process	GO:0008104	protein localization	Optn	IMP		Mouse	PMID:15607428
Biological Process	GO:0034067	protein localization to Golgi apparatus	OPTN	IMP		Human	PMID:15837803
Biological Process	GO:0051648	vesicle localization	optn	IMP	ZFIN:ZDB-GENO-150211-19	Zfish	PMID:25329564
Biological Process	GO:0042060	wound healing	Optn	IEP		Rat	PMID:16109995|RGD:7775038

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern