Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ORAI1
  • Mouse genes Orai1
  • Rat genes Orai1
  • Zfish genes orai1a,orai1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Orai1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005262	calcium channel activity	ORAI1	IDA		Human	PMID:31009446
Molecular Function	GO:0005246	calcium channel regulator activity	Orai1	IMP		Mouse	PMID:31664108
Molecular Function	GO:0099103	channel activator activity	Orai1	IMP		Mouse	PMID:31664108
Molecular Function	GO:0042802	identical protein binding	ORAI1	IPI	UniProtKB:Q96D31	Human	PMID:18757751
Molecular Function	GO:0042802	identical protein binding	ORAI1	IPI	UniProtKB:Q96D31	Human	PMID:19249086
Molecular Function	GO:0042802	identical protein binding	ORAI1	IPI	UniProtKB:Q96D31	Human	PMID:20018736
Molecular Function	GO:0042802	identical protein binding	ORAI1	IPI	UniProtKB:Q96D31	Human	PMID:20194792
Molecular Function	GO:0042802	identical protein binding	ORAI1	IPI	UniProtKB:Q96D31	Human	PMID:24996186
Molecular Function	GO:0099107	ion channel regulator activity involved in G protein-coupled receptor signaling pathway	Orai1	IMP		Mouse	PMID:31664108
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13507	Human	PMID:17360584
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q61143	Human	PMID:17360584
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:17905723
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q9P246	Human	PMID:17905723
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:19249086
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:19706554
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q9BRQ5	Human	PMID:19887627
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:20418871
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q9BSW2	Human	PMID:20418871
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:O75185	Human	PMID:20887894
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:P48995	Human	PMID:21408196
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:21427704
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:21876174
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:22451904
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:22464749
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:P40146	Human	PMID:22494970
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:22494970
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q12797-8	Human	PMID:22586105
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q9UMX0	Human	PMID:23307288
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:24954132
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q9BRQ5	Human	PMID:24954132
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:24996186
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:27185316
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:28219928
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586	Human	PMID:30481768
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q13586,UniProtKB:Q8N7U6	Human	PMID:30481768
Molecular Function	GO:0005515	protein binding	ORAI1	IPI	UniProtKB:Q8N7U6	Human	PMID:30481768
Molecular Function	GO:0005515	protein binding	Orai1	IPI	PR:A7L9Z8	Mouse	PMID:23840669
Molecular Function	GO:0005515	protein binding	Orai1	IPI	PR:P70302	Mouse	PMID:17343823
Molecular Function	GO:0005515	protein binding	Orai1	IPI	PR:Q80ZJ8	Mouse	PMID:20418871
Molecular Function	GO:0005515	protein binding	Orai1	IPI	UniProtKB:D4A5X1	Rat	PMID:23711249|RGD:10047297
Molecular Function	GO:0015279	store-operated calcium channel activity	ORAI1	IDA		Human	PMID:16645049
Molecular Function	GO:0015279	store-operated calcium channel activity	ORAI1	IDA		Human	PMID:16733527
Molecular Function	GO:0015279	store-operated calcium channel activity	ORAI1	IDA		Human	PMID:16766533
Molecular Function	GO:0015279	store-operated calcium channel activity	ORAI1	IDA		Human	PMID:16807233
Molecular Function	GO:0015279	store-operated calcium channel activity	ORAI1	IDA		Human	PMID:23307288
Molecular Function	GO:0015279	store-operated calcium channel activity	ORAI1	IDA		Human	PMID:28219928
Molecular Function	GO:0015279	store-operated calcium channel activity	Orai1	IMP		Mouse	PMID:31664108
Molecular Function	GO:0015279	store-operated calcium channel activity	Orai1	IMP		Rat	PMID:21389210|RGD:7175077
Cellular Component	GO:0016323	basolateral plasma membrane	Orai1	IDA		Mouse	PMID:23840669
Cellular Component	GO:0030426	growth cone	Orai1	IDA		Rat	PMID:22712562|RGD:7241221
Cellular Component	GO:0016020	membrane	ORAI1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Orai1	IDA		Mouse	PMID:17343823
Cellular Component	GO:0045121	membrane raft	ORAI1	IDA		Human	PMID:22494970
Cellular Component	GO:0005886	plasma membrane	ORAI1	IDA		Human	PMID:16645049
Cellular Component	GO:0005886	plasma membrane	ORAI1	IDA		Human	PMID:19171672
Cellular Component	GO:0005886	plasma membrane	ORAI1	IDA		Human	PMID:27185316
Cellular Component	GO:0005886	plasma membrane	ORAI1	IDA		Human	PMID:28219928
Cellular Component	GO:0005886	plasma membrane	Orai1	IDA		Mouse	PMID:17343823
Cellular Component	GO:0005886	plasma membrane	Orai1	IDA		Rat	PMID:21541286|RGD:7175076
Cellular Component	GO:0044853	plasma membrane raft	ORAI1	IDA		Human	PMID:19171672
Cellular Component	GO:0032991	protein-containing complex	Orai1	IPI	PR:P70302	Mouse	PMID:20418871
Biological Process	GO:0070509	calcium ion import	Orai1	IDA		Mouse	PMID:23840669
Biological Process	GO:0070588	calcium ion transmembrane transport	ORAI1	IDA		Human	PMID:31009446
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Orai1	IMP		Mouse	PMID:31664108
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Orai1	IMP		Mouse	PMID:31664108
Biological Process	GO:0061180	mammary gland epithelium development	Orai1	IMP		Mouse	PMID:23840669
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Orai1	IMP		Mouse	PMID:31664108
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	ORAI1	IDA		Human	PMID:19171672
Biological Process	GO:0051928	positive regulation of calcium ion transport	ORAI1	IDA		Human	PMID:16645049
Biological Process	GO:0051928	positive regulation of calcium ion transport	ORAI1	IDA		Human	PMID:16733527
Biological Process	GO:0051928	positive regulation of calcium ion transport	ORAI1	IDA		Human	PMID:16766533
Biological Process	GO:0051928	positive regulation of calcium ion transport	ORAI1	IDA		Human	PMID:16807233
Biological Process	GO:0032024	positive regulation of insulin secretion	Orai1	IMP		Mouse	PMID:31664108
Biological Process	GO:0051924	regulation of calcium ion transport	ORAI1	IMP		Human	PMID:16921383
Biological Process	GO:0045214	sarcomere organization	orai1b	IMP	ZFIN:ZDB-MRPHLNO-120312-2	Zfish	PMID:22302996
Biological Process	GO:0002115	store-operated calcium entry	ORAI1	IDA		Human	PMID:28219928
Biological Process	GO:0002115	store-operated calcium entry	Orai1	IGI	MGI:MGI:107476	Mouse	PMID:17343823
Biological Process	GO:0002115	store-operated calcium entry	Orai1	IGI	MGI:MGI:2446129	Mouse	PMID:20418871
Biological Process	GO:0002115	store-operated calcium entry	Orai1	IMP		Rat	PMID:21389210|RGD:7175077

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern