Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ORMDL3
  • Mouse genes Ormdl3
  • Rat genes Ormdl3
  • Zfish genes ormdl3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ormdl3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:O15269	Human	PMID:20182505
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:O00258	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:O95214	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:O95279	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:P30825	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q03395	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q14973	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q86VR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q8IU89	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q8IYJ2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q8N9I0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q8NI60	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q96P66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q99942	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q9BRK0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q9GZR5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q9H2K0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q9NQQ7-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ORMDL3	IPI	UniProtKB:O15269	Human	PMID:33558761
Cellular Component	GO:0005783	endoplasmic reticulum	ORMDL3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	ORMDL3	IDA		Human	PMID:12093374
Cellular Component	GO:0035339	SPOTS complex	ORMDL3	IDA		Human	PMID:20182505
Cellular Component	GO:0035339	SPOTS complex	ORMDL3	IDA		Human	PMID:25691431
Biological Process	GO:0006672	ceramide metabolic process	ORMDL3	IMP		Human	PMID:20182505
Biological Process	GO:0061744	motor behavior	Ormdl3	IGI	MGI:MGI:2181669	Mouse	PMID:31880535
Biological Process	GO:0042552	myelination	Ormdl3	IGI	MGI:MGI:2181669	Mouse	PMID:31880535
Biological Process	GO:0002903	negative regulation of B cell apoptotic process	ORMDL3	IMP		Human	PMID:28747345
Biological Process	GO:0002903	negative regulation of B cell apoptotic process	Ormdl3	IMP	MGI:MGI:6369059	Mouse	PMID:28747345
Biological Process	GO:1900060	negative regulation of ceramide biosynthetic process	ORMDL3	IMP		Human	PMID:25691431
Biological Process	GO:1900060	negative regulation of ceramide biosynthetic process	Ormdl3	IDA		Mouse	PMID:25691431
Biological Process	GO:1904221	negative regulation of serine C-palmitoyltransferase activity	Ormdl3	IMP	MGI:MGI:6382064,MGI:MGI:2137691	Mouse	PMID:31880535
Biological Process	GO:1904221	negative regulation of serine C-palmitoyltransferase activity	Ormdl3	IMP		Mouse	PMID:28275141
Biological Process	GO:0010508	positive regulation of autophagy	ORMDL3	IDA		Human	PMID:28747345
Biological Process	GO:0010508	positive regulation of autophagy	ORMDL3	IMP		Human	PMID:28747345
Biological Process	GO:0010508	positive regulation of autophagy	Ormdl3	IMP	MGI:MGI:6369059	Mouse	PMID:28747345
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ORMDL3	IDA		Human	PMID:28747345
Biological Process	GO:2000303	regulation of ceramide biosynthetic process	Ormdl3	IGI	MGI:MGI:2181669	Mouse	PMID:31880535
Biological Process	GO:2000303	regulation of ceramide biosynthetic process	Ormdl3	IMP	MGI:MGI:6382064,MGI:MGI:2137691	Mouse	PMID:31880535
Biological Process	GO:0006940	regulation of smooth muscle contraction	Ormdl3	IMP		Mouse	PMID:28275141
Biological Process	GO:0090153	regulation of sphingolipid biosynthetic process	Ormdl3	IMP	MGI:MGI:6382064,MGI:MGI:2137691	Mouse	PMID:31880535
Biological Process	GO:0090153	regulation of sphingolipid biosynthetic process	Ormdl3	IGI	MGI:MGI:2181669	Mouse	PMID:31880535
Biological Process	GO:0090153	regulation of sphingolipid biosynthetic process	Ormdl3	IMP	MGI:MGI:2445707,MGI:MGI:6343506	Mouse	PMID:28275141
Biological Process	GO:0090153	regulation of sphingolipid biosynthetic process	Ormdl3	IMP		Mouse	PMID:28275141
Biological Process	GO:0006686	sphingomyelin biosynthetic process	Ormdl3	IMP	MGI:MGI:6382064,MGI:MGI:2137691	Mouse	PMID:31880535
Biological Process	GO:0006686	sphingomyelin biosynthetic process	Ormdl3	IGI	MGI:MGI:2181669	Mouse	PMID:31880535

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern