Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OTC
  • Mouse genes Otc
  • Rat genes Otc
  • Zfish genes otc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Otc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016597	amino acid binding	Otc	IMP		Rat	PMID:2290837|RGD:1582378
Molecular Function	GO:0042802	identical protein binding	Otc	IPI	RGD:3236	Rat	PMID:2290837|RGD:1582378
Molecular Function	GO:0004585	ornithine carbamoyltransferase activity	OTC	IDA		Human	PMID:2556444
Molecular Function	GO:0004585	ornithine carbamoyltransferase activity	OTC	IDA		Human	PMID:8112735
Molecular Function	GO:0004585	ornithine carbamoyltransferase activity	Otc	IMP		Rat	PMID:2290837|RGD:1582378
Molecular Function	GO:0004585	ornithine carbamoyltransferase activity	Otc	IDA		Rat	PMID:3680220|RGD:1582379
Molecular Function	GO:0004585	ornithine carbamoyltransferase activity	Otc	IDA		Rat	PMID:4062872|RGD:2300098
Molecular Function	GO:0042301	phosphate ion binding	Otc	IMP		Rat	PMID:2290837|RGD:1582378
Molecular Function	GO:0005543	phospholipid binding	Otc	IDA		Rat	PMID:3680220|RGD:1582379
Cellular Component	GO:0005737	cytoplasm	Otc	IDA		Rat	PMID:3527129|RGD:2303522
Cellular Component	GO:0005743	mitochondrial inner membrane	Otc	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005743	mitochondrial inner membrane	Otc	IDA		Rat	PMID:3680220|RGD:1582379
Cellular Component	GO:0005739	mitochondrion	OTC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	OTC	IDA		Human	PMID:3472484
Cellular Component	GO:0005739	mitochondrion	OTC	IDA		Human	PMID:6372096
Cellular Component	GO:0005739	mitochondrion	Otc	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Otc	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Otc	IDA		Rat	PMID:2290837|RGD:1582378
Biological Process	GO:0097272	ammonium homeostasis	OTC	IMP		Human	PMID:2556444
Biological Process	GO:0097272	ammonium homeostasis	OTC	IMP		Human	PMID:2575934
Biological Process	GO:0019240	citrulline biosynthetic process	OTC	IDA		Human	PMID:2556444
Biological Process	GO:0019240	citrulline biosynthetic process	OTC	IDA		Human	PMID:8112735
Biological Process	GO:0019240	citrulline biosynthetic process	Otc	IDA		Rat	PMID:9472964|RGD:4144071
Biological Process	GO:0001889	liver development	Otc	IEP		Rat	PMID:8690412|RGD:4144072
Biological Process	GO:0007494	midgut development	Otc	IEP		Rat	PMID:9544996|RGD:4139911
Biological Process	GO:0055081	monoatomic anion homeostasis	Otc	IDA		Rat	PMID:4062872|RGD:2300098
Biological Process	GO:0006593	ornithine catabolic process	OTC	IDA		Human	PMID:2556444
Biological Process	GO:0006593	ornithine catabolic process	OTC	IDA		Human	PMID:8112735
Biological Process	GO:0006591	ornithine metabolic process	Otc	IDA		Rat	PMID:4062872|RGD:2300098
Biological Process	GO:0070781	response to biotin	Otc	IEP		Rat	PMID:8558326|RGD:4144076
Biological Process	GO:0032868	response to insulin	Otc	IEP		Rat	PMID:9628242|RGD:4144123
Biological Process	GO:0031667	response to nutrient levels	Otc	IEP		Rat	PMID:9628242|RGD:4144123
Biological Process	GO:0009410	response to xenobiotic stimulus	Otc	IEP		Rat	PMID:14625847|RGD:4144097
Biological Process	GO:0010043	response to zinc ion	Otc	IEP		Rat	PMID:11686784|RGD:1599309
Biological Process	GO:0000050	urea cycle	OTC	IDA		Human	PMID:2556444
Biological Process	GO:0000050	urea cycle	Otc	IDA		Rat	PMID:3680220|RGD:1582379
Biological Process	GO:0000050	urea cycle	Otc	IDA		Rat	PMID:4062872|RGD:2300098

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern