Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OTP
  • Mouse genes Otp
  • Rat genes Otp
  • Zfish genes otpa,otpb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Otp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	OTP	IDA		Human	PMID:29107289
Molecular Function	GO:0005515	protein binding	OTP	IPI	UniProtKB:O00585	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTP	IPI	UniProtKB:O43924	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTP	IPI	UniProtKB:O95936-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTP	IPI	UniProtKB:Q00534	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTP	IPI	UniProtKB:Q68CL5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTP	IPI	UniProtKB:Q9HBH7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTP	IPI	UniProtKB:Q9UBL6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTP	IPI	UniProtKB:Q9Y666-2	Human	PMID:32296183
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	OTP	IDA		Human	PMID:29107289
Cellular Component	GO:0001650	fibrillar center	OTP	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	OTP	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	OTP	IDA		Human	GO_REF:0000052
Biological Process	GO:0071542	dopaminergic neuron differentiation	Otp	IMP	MGI:MGI:2180541	Mouse	PMID:17481897
Biological Process	GO:0071542	dopaminergic neuron differentiation	otpa	IMP	ZFIN:ZDB-GENO-100427-8	Zfish	PMID:24073233
Biological Process	GO:0021884	forebrain neuron development	otpa	IMP	ZFIN:ZDB-MRPHLNO-070531-4	Zfish	PMID:17481897
Biological Process	GO:0021884	forebrain neuron development	otpa	IGI	ZFIN:ZDB-GENO-070531-3,ZFIN:ZDB-MRPHLNO-070531-5	Zfish	PMID:17481897
Biological Process	GO:0021884	forebrain neuron development	otpa	IGI	ZFIN:ZDB-GENO-070531-3,ZFIN:ZDB-MRPHLNO-070612-8	Zfish	PMID:17481897
Biological Process	GO:0021884	forebrain neuron development	otpa	IMP	ZFIN:ZDB-GENO-070531-3	Zfish	PMID:17481897
Biological Process	GO:0021884	forebrain neuron development	otpb	IGI	ZFIN:ZDB-GENO-070531-3,ZFIN:ZDB-MRPHLNO-070531-5	Zfish	PMID:17481897
Biological Process	GO:0021884	forebrain neuron development	otpb	IGI	ZFIN:ZDB-GENO-070531-3,ZFIN:ZDB-MRPHLNO-070612-8	Zfish	PMID:17481897
Biological Process	GO:0021879	forebrain neuron differentiation	Otp	IMP	MGI:MGI:2180541	Mouse	PMID:17481897
Biological Process	GO:0021979	hypothalamus cell differentiation	Otp	IMP	MGI:MGI:2180541	Mouse	PMID:10557207
Biological Process	GO:0021854	hypothalamus development	otpb	IMP	ZFIN:ZDB-MRPHLNO-080414-1	Zfish	PMID:18003738
Biological Process	GO:0021767	mammillary body development	otpa	IGI	ZFIN:ZDB-GENO-100427-8,ZFIN:ZDB-MRPHLNO-070531-5	Zfish	PMID:23533176
Biological Process	GO:0021767	mammillary body development	otpb	IGI	ZFIN:ZDB-GENO-100427-8,ZFIN:ZDB-MRPHLNO-070531-5	Zfish	PMID:23533176
Biological Process	GO:0042552	myelination	otpa	IGI	ZFIN:ZDB-CRISPR-200811-1,ZFIN:ZDB-CRISPR-200811-2	Zfish	PMID:32122379
Biological Process	GO:0042552	myelination	otpb	IGI	ZFIN:ZDB-CRISPR-200811-1,ZFIN:ZDB-CRISPR-200811-2	Zfish	PMID:32122379
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	OTP	IDA		Human	PMID:29107289
Biological Process	GO:0007405	neuroblast proliferation	Otp	IMP	MGI:MGI:2180541	Mouse	PMID:10557207
Biological Process	GO:0061101	neuroendocrine cell differentiation	Otp	IMP	MGI:MGI:2180541	Mouse	PMID:10557207
Biological Process	GO:0021985	neurohypophysis development	Otp	IMP	MGI:MGI:2180541	Mouse	PMID:10557207
Biological Process	GO:0030182	neuron differentiation	otpa	IGI	ZFIN:ZDB-GENE-990708-7,ZFIN:ZDB-GENO-130128-13	Zfish	PMID:24073233
Biological Process	GO:0030182	neuron differentiation	otpa	IMP	ZFIN:ZDB-GENO-100427-8	Zfish	PMID:24073233
Biological Process	GO:0030182	neuron differentiation	otpb	IGI	ZFIN:ZDB-GENE-070216-1,ZFIN:ZDB-GENO-130128-13	Zfish	PMID:24073233
Biological Process	GO:0030182	neuron differentiation	otpb	IMP	ZFIN:ZDB-GENO-130110-10	Zfish	PMID:24073233
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	Otp	IMP	MGI:MGI:2180541	Mouse	PMID:10557207
Biological Process	GO:0035176	social behavior	otpa	IMP	ZFIN:ZDB-GENO-100427-8	Zfish	PMID:28094761
Biological Process	GO:0021522	spinal cord motor neuron differentiation	otpa	IMP	ZFIN:ZDB-GENO-100427-8	Zfish	PMID:23707737
Biological Process	GO:0007632	visual behavior	otpa	IMP	ZFIN:ZDB-GENO-130125-7	Zfish	PMID:23000151

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern