Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OTULIN
  • Mouse genes Otulin
  • Rat genes Otulin
  • Zfish genes otulina,otulinb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Otulin

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	OTULIN	IDA		Human	PMID:23746843
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	OTULIN	IDA		Human	PMID:23806334
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	OTULIN	IDA		Human	PMID:23827681
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	OTULIN	IDA		Human	PMID:24726323
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	OTULIN	IDA		Human	PMID:24726327
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	OTULIN	EXP		Human	PMID:26235645
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	OTULIN	IDA		Human	PMID:26997266
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	OTULIN	IDA		Human	PMID:27523608
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	OTULIN	IDA		Human	PMID:27559085
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	OTULIN	IMP		Human	PMID:35170849
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	OTULIN	IMP		Human	PMID:35587511
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	Otulin	IDA		Mouse	MGI:MGI:5804663|PMID:27523608
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	Otulin	IDA		Mouse	MGI:MGI:6192867|PMID:29950720
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	Otulin	IDA		Mouse	MGI:MGI:5494328|PMID:23708998
Molecular Function	GO:0008234	cysteine-type peptidase activity	OTULIN	IMP		Human	PMID:23746843
Molecular Function	GO:0008234	cysteine-type peptidase activity	Otulin	IMP		Mouse	MGI:MGI:5494328|PMID:23708998
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:O14641	Human	PMID:23708998
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q96EP0	Human	PMID:23708998
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q96EP0	Human	PMID:24726323
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q15038	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q92567	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q96EP0	Human	PMID:27523608
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q96EP0	Human	PMID:27559085
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q15038	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q6GQQ9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q8N0X7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q8WV19	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q8WW34-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q92537	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	OTULIN	IPI	UniProtKB:Q92567-2	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	OTULIN	IDA		Human	PMID:23746843
Cellular Component	GO:0005737	cytoplasm	Otulin	IDA		Mouse	MGI:MGI:5494328|PMID:23708998
Cellular Component	GO:0071797	LUBAC complex	Otulin	IDA		Mouse	MGI:MGI:5494328|PMID:23708998
Biological Process	GO:0045087	innate immune response	OTULIN	IMP		Human	PMID:23806334
Biological Process	GO:0045087	innate immune response	OTULIN	IDA		Human	PMID:26997266
Biological Process	GO:0050728	negative regulation of inflammatory response	OTULIN	IMP		Human	PMID:23806334
Biological Process	GO:0050728	negative regulation of inflammatory response	OTULIN	IMP		Human	PMID:27523608
Biological Process	GO:0050728	negative regulation of inflammatory response	OTULIN	IMP		Human	PMID:27559085
Biological Process	GO:0050728	negative regulation of inflammatory response	Otulin	IMP		Mouse	MGI:MGI:6192867|PMID:29950720
Biological Process	GO:0050728	negative regulation of inflammatory response	Otulin	IMP		Mouse	MGI:MGI:5804663|PMID:27523608
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	OTULIN	IDA		Human	PMID:23746843
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	OTULIN	IMP		Human	PMID:23806334
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	OTULIN	IDA		Human	PMID:24726327
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	OTULIN	IMP		Human	PMID:27523608
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	OTULIN	IDA		Human	PMID:27559085
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	OTULIN	IMP		Human	PMID:35170849
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	OTULIN	IMP		Human	PMID:35587511
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	Otulin	IMP		Mouse	MGI:MGI:5804663|PMID:27523608
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	OTULIN	IMP		Human	PMID:23806334
Biological Process	GO:1990108	protein linear deubiquitination	OTULIN	IDA		Human	PMID:23746843
Biological Process	GO:1990108	protein linear deubiquitination	OTULIN	IDA		Human	PMID:23806334
Biological Process	GO:1990108	protein linear deubiquitination	OTULIN	IDA		Human	PMID:23827681
Biological Process	GO:1990108	protein linear deubiquitination	OTULIN	IDA		Human	PMID:24726323
Biological Process	GO:1990108	protein linear deubiquitination	OTULIN	IDA		Human	PMID:24726327
Biological Process	GO:1990108	protein linear deubiquitination	OTULIN	IDA		Human	PMID:26997266
Biological Process	GO:1990108	protein linear deubiquitination	OTULIN	IDA		Human	PMID:27523608
Biological Process	GO:1990108	protein linear deubiquitination	OTULIN	IDA		Human	PMID:27559085
Biological Process	GO:1990108	protein linear deubiquitination	Otulin	IDA		Mouse	MGI:MGI:5804663|PMID:27523608
Biological Process	GO:1990108	protein linear deubiquitination	Otulin	IDA		Mouse	MGI:MGI:6192867|PMID:29950720
Biological Process	GO:1990108	protein linear deubiquitination	Otulin	IDA		Mouse	MGI:MGI:5494328|PMID:23708998
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	Otulin	IDA		Mouse	MGI:MGI:5494328|PMID:23708998
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	OTULIN	IDA		Human	PMID:26997266
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Otulin	IMP		Mouse	MGI:MGI:6192867|PMID:29950720
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Otulin	IMP		Mouse	MGI:MGI:5804663|PMID:27523608
Biological Process	GO:0002040	sprouting angiogenesis	Otulin	IMP		Mouse	MGI:MGI:5494328|PMID:23708998

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern