Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OTX2
  • Mouse genes Otx2
  • Rat genes Otx2
  • Zfish genes otx2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Otx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	OTX2	IDA		Human	PMID:12559959
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	OTX2	IDA		Human	PMID:20530484
Molecular Function	GO:0005515	protein binding	OTX2	IPI	UniProtKB:P48436	Human	PMID:20530484
Molecular Function	GO:0005515	protein binding	Otx2	IPI	UniProtKB:Q62441	Mouse	MGI:MGI:6245330|PMID:17060451
Molecular Function	GO:0005515	protein binding	Otx2	IPI	PR:Q91ZK4	Mouse	PMID:15890343
Molecular Function	GO:0005515	protein binding	Otx2	IPI	PR:Q62441	Mouse	PMID:15105370
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	OTX2	IDA		Human	PMID:12559959
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	OTX2	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Otx2	IDA		Mouse	PMID:10891582
Cellular Component	GO:0030426	growth cone	OTX2	IDA		Human	PMID:16267555
Cellular Component	GO:0005634	nucleus	OTX2	IDA		Human	PMID:24399192
Cellular Component	GO:0005634	nucleus	Otx2	IDA		Mouse	PMID:22992956
Cellular Component	GO:0005634	nucleus	Otx2	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005634	nucleus	Otx2	IDA		Mouse	PMID:10891582
Cellular Component	GO:0005634	nucleus	Otx2	IDA		Mouse	PMID:23056351
Cellular Component	GO:0032991	protein-containing complex	OTX2	IDA		Human	PMID:20530484
Cellular Component	GO:0005667	transcription regulator complex	Otx2	IDA		Mouse	PMID:26494787
Biological Process	GO:0048856	anatomical structure development	Otx2	IGI	MGI:MGI:109448	Mouse	PMID:11412024
Biological Process	GO:0009887	animal organ morphogenesis	Otx2	IMP	MGI:MGI:2178753	Mouse	PMID:14625556
Biological Process	GO:0009952	anterior/posterior pattern specification	Otx2	IMP	MGI:MGI:1857502	Mouse	PMID:9501024
Biological Process	GO:0009952	anterior/posterior pattern specification	Otx2	IGI	MGI:MGI:109448	Mouse	PMID:11412024
Biological Process	GO:0009952	anterior/posterior pattern specification	Otx2	IMP	MGI:MGI:2661067	Mouse	PMID:12652306
Biological Process	GO:0007411	axon guidance	OTX2	IDA		Human	PMID:16267555
Biological Process	GO:0045165	cell fate commitment	Otx2	IMP	MGI:MGI:2661065	Mouse	PMID:15105370
Biological Process	GO:0097306	cellular response to alcohol	otx2b	IDA		Zfish	PMID:17013923
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Otx2	IEP		Mouse	PMID:20439489
Biological Process	GO:0007417	central nervous system development	Otx2	IMP	MGI:MGI:2150146	Mouse	PMID:11731459
Biological Process	GO:0007417	central nervous system development	Otx2	IMP	MGI:MGI:2661067	Mouse	PMID:12652306
Biological Process	GO:0007417	central nervous system development	Otx2	IMP	MGI:MGI:1857510	Mouse	PMID:11731459
Biological Process	GO:0021549	cerebellum development	otx2b	IGI	ZFIN:ZDB-GENO-140305-1,ZFIN:ZDB-MRPHLNO-060620-3,ZFIN:ZDB-MRPHLNO-060620-5	Zfish	PMID:24183937
Biological Process	GO:0048852	diencephalon morphogenesis	Otx2	IGI	MGI:MGI:97450	Mouse	PMID:20816794
Biological Process	GO:0071542	dopaminergic neuron differentiation	OTX2	IGI	UniProtKB:Q9JKU8,UniProtKB:Q9Y261	Human	PMID:19951692
Biological Process	GO:0071542	dopaminergic neuron differentiation	Otx2	IMP	MGI:MGI:2176222,MGI:MGI:2661065	Mouse	PMID:15888661
Biological Process	GO:0009953	dorsal/ventral pattern formation	Otx2	IMP	MGI:MGI:2661067	Mouse	PMID:12652306
Biological Process	GO:0007492	endoderm development	Otx2	IGI	MGI:MGI:109448	Mouse	PMID:11412024
Biological Process	GO:0042706	eye photoreceptor cell fate commitment	Otx2	IMP	MGI:MGI:2178753	Mouse	PMID:14625556
Biological Process	GO:0030900	forebrain development	Otx2	IGI	MGI:MGI:97450	Mouse	PMID:15201223
Biological Process	GO:0030900	forebrain development	Otx2	IGI	MGI:MGI:95388	Mouse	PMID:15917450
Biological Process	GO:0030900	forebrain development	Otx2	IMP	MGI:MGI:2178753	Mouse	PMID:14625556
Biological Process	GO:0030900	forebrain development	Otx2	IMP	MGI:MGI:1857510	Mouse	PMID:15201223
Biological Process	GO:0030900	forebrain development	Otx2	IMP	MGI:MGI:3046841	Mouse	PMID:15201223
Biological Process	GO:0030902	hindbrain development	otx2b	IGI	ZFIN:ZDB-GENO-980202-822,ZFIN:ZDB-MRPHLNO-060620-3,ZFIN:ZDB-MRPHLNO-060620-5	Zfish	PMID:16611693
Biological Process	GO:0042472	inner ear morphogenesis	Otx2	IGI	MGI:MGI:97450	Mouse	PMID:10225993
Biological Process	GO:0048382	mesendoderm development	Otx2	IMP	MGI:MGI:5698524,MGI:MGI:2656539	Mouse	PMID:26494787
Biological Process	GO:0022037	metencephalon development	Otx2	IGI	MGI:MGI:97450	Mouse	PMID:20816794
Biological Process	GO:0030901	midbrain development	Otx2	IGI	MGI:MGI:97450	Mouse	PMID:15201224
Biological Process	GO:0030901	midbrain development	Otx2	IMP	MGI:MGI:3046841	Mouse	PMID:15201223
Biological Process	GO:0030901	midbrain development	Otx2	IMP	MGI:MGI:2176222,MGI:MGI:2661065	Mouse	PMID:15888661
Biological Process	GO:0030901	midbrain development	Otx2	IMP	MGI:MGI:1857510	Mouse	PMID:15201223
Biological Process	GO:0030901	midbrain development	Otx2	IGI	MGI:MGI:97450	Mouse	PMID:20816794
Biological Process	GO:0030901	midbrain development	otx2b	IGI	ZFIN:ZDB-MRPHLNO-060620-3,ZFIN:ZDB-MRPHLNO-060620-5	Zfish	PMID:16611693
Biological Process	GO:0030917	midbrain-hindbrain boundary development	otx2b	IGI	ZFIN:ZDB-MRPHLNO-060620-3,ZFIN:ZDB-MRPHLNO-060620-5	Zfish	PMID:16611693
Biological Process	GO:0060563	neuroepithelial cell differentiation	Otx2	IMP	MGI:MGI:2178753	Mouse	PMID:14625556
Biological Process	GO:0048663	neuron fate commitment	Otx2	IMP	MGI:MGI:2178753,MGI:MGI:3665330	Mouse	PMID:26166575
Biological Process	GO:0048663	neuron fate commitment	Otx2	IMP	MGI:MGI:2446434,MGI:MGI:2661065	Mouse	PMID:16339193
Biological Process	GO:0048664	neuron fate determination	Otx2	IMP	MGI:MGI:2446434,MGI:MGI:2661065	Mouse	PMID:19592574
Biological Process	GO:0048665	neuron fate specification	Otx2	IMP	MGI:MGI:2176222,MGI:MGI:2661065	Mouse	PMID:15888661
Biological Process	GO:0048709	oligodendrocyte differentiation	Otx2	IMP	MGI:MGI:2178753,MGI:MGI:3665330	Mouse	PMID:26166575
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Otx2	IMP		Mouse	MGI:MGI:2157654|PMID:11291865
Biological Process	GO:0040019	positive regulation of embryonic development	Otx2	IMP		Mouse	MGI:MGI:2157654|PMID:11291865
Biological Process	GO:2000543	positive regulation of gastrulation	Otx2	IMP		Mouse	MGI:MGI:2157654|PMID:11291865
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	OTX2	IDA		Human	PMID:12559959
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	OTX2	IDA		Human	PMID:20530484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Otx2	IGI	MGI:MGI:2153518	Mouse	PMID:15890343
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Otx2	IDA		Mouse	PMID:16539743
Biological Process	GO:0090009	primitive streak formation	Otx2	IMP	MGI:MGI:1857502	Mouse	PMID:11291865
Biological Process	GO:0065003	protein-containing complex assembly	OTX2	IDA		Human	PMID:20530484
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Otx2	IDA		Mouse	PMID:15105370
Biological Process	GO:0003406	retinal pigment epithelium development	otx2b	IGI	ZFIN:ZDB-MRPHLNO-060411-1,ZFIN:ZDB-MRPHLNO-060620-3,ZFIN:ZDB-MRPHLNO-060620-5	Zfish	PMID:23139843
Biological Process	GO:0003406	retinal pigment epithelium development	otx2b	IGI	ZFIN:ZDB-MRPHLNO-060620-3,ZFIN:ZDB-MRPHLNO-060620-5	Zfish	PMID:23139843
Biological Process	GO:0003406	retinal pigment epithelium development	otx2b	IGI	ZFIN:ZDB-GENO-130107-2,ZFIN:ZDB-MRPHLNO-060620-3,ZFIN:ZDB-MRPHLNO-060620-5	Zfish	PMID:23139843
Biological Process	GO:0032525	somite rostral/caudal axis specification	Otx2	IMP	MGI:MGI:1857502	Mouse	PMID:11291865
Biological Process	GO:0021978	telencephalon regionalization	Otx2	IMP	MGI:MGI:2178753,MGI:MGI:3665330	Mouse	PMID:26166575

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern