Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OVOL2
  • Mouse genes Ovol2
  • Rat genes Ovol2
  • Zfish genes zgc:171929
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ovol2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Ovol2	IDA		Mouse	PMID:24735878
Molecular Function	GO:0003677	DNA binding	Ovol2	IDA		Mouse	PMID:15225875
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Ovol2	IDA		Mouse	PMID:24735878
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Ovol2	IDA		Mouse	MGI:MGI:6284898|PMID:28455959
Molecular Function	GO:0005515	protein binding	OVOL2	IPI	UniProtKB:Q8TF50	Human	PMID:32296183
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	OVOL2	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Ovol2	IDA		Mouse	PMID:24735878
Cellular Component	GO:0005634	nucleus	Ovol2	IDA		Mouse	PMID:9468311
Cellular Component	GO:0005634	nucleus	Ovol2	IDA		Mouse	PMID:17049212
Cellular Component	GO:0005634	nucleus	zgc:171929	IDA		Zfish	PMID:20463035
Biological Process	GO:0001525	angiogenesis	Ovol2	IMP	MGI:MGI:3777011	Mouse	PMID:17573777
Biological Process	GO:0008283	cell population proliferation	Ovol2	IMP	MGI:MGI:3522498	Mouse	PMID:16423343
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Ovol2	IDA		Mouse	MGI:MGI:6284898|PMID:28455959
Biological Process	GO:0009953	dorsal/ventral pattern formation	Ovol2	IMP	MGI:MGI:3522498	Mouse	PMID:16423343
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	Ovol2	IMP	MGI:MGI:3522498	Mouse	PMID:16423343
Biological Process	GO:0060214	endocardium formation	Ovol2	IMP	MGI:MGI:3777011	Mouse	PMID:17573777
Biological Process	GO:0009913	epidermal cell differentiation	Ovol2	IMP		Mouse	MGI:MGI:5574425|PMID:24735879
Biological Process	GO:0008544	epidermis development	Ovol2	IGI	MGI:MGI:1330290	Mouse	PMID:24735878
Biological Process	GO:0007507	heart development	Ovol2	IMP	MGI:MGI:3522498	Mouse	PMID:16423343
Biological Process	GO:0001947	heart looping	Ovol2	IMP	MGI:MGI:3777011	Mouse	PMID:17573777
Biological Process	GO:0060347	heart trabecula formation	Ovol2	IMP	MGI:MGI:3777011	Mouse	PMID:17573777
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Ovol2	IMP	MGI:MGI:3777011	Mouse	PMID:17573777
Biological Process	GO:0008285	negative regulation of cell population proliferation	Ovol2	IMP	MGI:MGI:3522498	Mouse	PMID:16423343
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	Ovol2	IMP		Mouse	MGI:MGI:5574425|PMID:24735879
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	Ovol2	IDA		Mouse	MGI:MGI:6284898|PMID:28455959
Biological Process	GO:0010629	negative regulation of gene expression	Ovol2	IDA		Mouse	MGI:MGI:6284898|PMID:28455959
Biological Process	GO:2000647	negative regulation of stem cell proliferation	Ovol2	IGI	MGI:MGI:1330290	Mouse	PMID:24735878
Biological Process	GO:0001755	neural crest cell migration	Ovol2	IMP	MGI:MGI:3522498	Mouse	PMID:16423343
Biological Process	GO:0001842	neural fold formation	Ovol2	IMP	MGI:MGI:3522498	Mouse	PMID:16423343
Biological Process	GO:0010628	positive regulation of gene expression	Ovol2	IDA		Mouse	MGI:MGI:6284898|PMID:28455959
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	Ovol2	IDA		Mouse	PMID:24735878
Biological Process	GO:0010837	regulation of keratinocyte proliferation	Ovol2	IMP		Mouse	MGI:MGI:4359298|PMID:19700410
Biological Process	GO:0060390	regulation of SMAD protein signal transduction	Ovol2	IDA		Mouse	MGI:MGI:6284898|PMID:28455959

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern