Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse P2rx2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes P2RX2
- Mouse genes P2rx2
- Rat genes P2rx2
- Zfish genes p2rx2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set P2rx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	P2rx2	IDA		Rat	PMID:16190872\|RGD:1642665
Molecular Function	GO:0005524	ATP binding	P2rx2	IDA		Rat	PMID:16388598\|RGD:1642662
Molecular Function	GO:0005524	ATP binding	P2rx2	IDA		Rat	PMID:16934235\|RGD:1642659
Molecular Function	GO:0005524	ATP binding	P2rx2	IDA		Rat	PMID:17517890\|RGD:1642653
Molecular Function	GO:0046870	cadmium ion binding	P2rx2	IDA		Rat	PMID:16190872\|RGD:1642665
Molecular Function	GO:0050897	cobalt ion binding	P2rx2	IDA		Rat	PMID:16190872\|RGD:1642665
Molecular Function	GO:0005507	copper ion binding	P2rx2	IDA		Rat	PMID:16190872\|RGD:1642665
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2RX2	IDA		Human	PMID:23345450
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:15081800
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx2	IGI	MGI:MGI:1097160	Mouse	PMID:15081800
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx2	IDA		Mouse	PMID:12917379
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx2	IMP		Rat	PMID:15317863\|RGD:1642666
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx2	IDA		Rat	PMID:16190872\|RGD:1642665
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx2	IMP		Rat	PMID:16857707\|RGD:1642661
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx2	IDA		Rat	PMID:16934235\|RGD:1642659
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx2	IDA		Rat	PMID:17517890\|RGD:1642653
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx2	IGI	ZFIN:ZDB-GENE-000427-3	Zfish	PMID:14580944
Molecular Function	GO:0042802	identical protein binding	P2RX2	IPI	UniProtKB:Q9UBL9	Human	PMID:15313628
Molecular Function	GO:0042802	identical protein binding	P2rx2	IPI	RGD:620251	Rat	PMID:15313628\|RGD:1581703
Molecular Function	GO:0042802	identical protein binding	P2rx2	IPI	UniProtKB:P49653	Rat	PMID:15313628\|RGD:1581703
Molecular Function	GO:0042802	identical protein binding	P2rx2	IPI	UniProtKB:P49653-1	Rat	PMID:19217397\|RGD:13432270
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	P2rx2	IDA		Rat	PMID:7542879\|RGD:633339
Molecular Function	GO:0045340	mercury ion binding	P2rx2	IDA		Rat	PMID:16190872\|RGD:1642665
Molecular Function	GO:0016151	nickel cation binding	P2rx2	IDA		Rat	PMID:16190872\|RGD:1642665
Molecular Function	GO:0035091	phosphatidylinositol binding	P2rx2	IMP		Rat	PMID:16857707\|RGD:1642661
Molecular Function	GO:0005515	protein binding	P2rx2	IPI	RGD:2122	Rat	PMID:16330549\|RGD:2301201
Molecular Function	GO:0005515	protein binding	P2rx2	IPI	UniProtKB:P51577	Rat	PMID:24815693\|RGD:8693375
Molecular Function	GO:0005515	protein binding	P2rx2	IPI	UniProtKB:P51579	Rat	PMID:24815693\|RGD:8693375
Molecular Function	GO:0044877	protein-containing complex binding	P2rx2	IDA		Rat	PMID:15313628\|RGD:1581703
Molecular Function	GO:0044877	protein-containing complex binding	P2rx2	IDA		Rat	PMID:17449665\|RGD:1642655
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	P2rx2	IDA		Rat	PMID:16388598\|RGD:1642662
Molecular Function	GO:0043924	suramin binding	P2rx2	IDA		Rat	PMID:16388598\|RGD:1642662
Molecular Function	GO:0008270	zinc ion binding	P2rx2	IDA		Rat	PMID:16190872\|RGD:1642665
Molecular Function	GO:0008270	zinc ion binding	P2rx2	IDA		Rat	PMID:17517890\|RGD:1642653
Cellular Component	GO:0016324	apical plasma membrane	P2RX2	IDA		Human	PMID:23345450
Cellular Component	GO:0009986	cell surface	P2rx2	IDA		Rat	PMID:18616429\|RGD:7242066
Cellular Component	GO:0043197	dendritic spine	P2rx2	IDA		Rat	PMID:11160443\|RGD:1642669
Cellular Component	GO:0098978	glutamatergic synapse	P2rx2	EXP		Rat	PMID:16000618\|RGD:1581702
Cellular Component	GO:0098978	glutamatergic synapse	P2rx2	IDA		Rat	PMID:16000618\|RGD:1581702
Cellular Component	GO:0005622	intracellular anatomical structure	P2rx2	IDA		Mouse	PMID:15961431
Cellular Component	GO:0016020	membrane	P2rx2	IDA		Rat	PMID:15317863\|RGD:1642666
Cellular Component	GO:0016020	membrane	P2rx2	IDA		Rat	PMID:17449665\|RGD:1642655
Cellular Component	GO:0043025	neuronal cell body	P2rx2	IDA		Rat	PMID:10974431\|RGD:1642670
Cellular Component	GO:0043025	neuronal cell body	P2rx2	IDA		Rat	PMID:11160443\|RGD:1642669
Cellular Component	GO:0043025	neuronal cell body	P2rx2	IDA		Rat	PMID:12849743\|RGD:13673769
Cellular Component	GO:0098992	neuronal dense core vesicle	P2rx2	IDA		Mouse	PMID:21321602
Cellular Component	GO:0098992	neuronal dense core vesicle	P2rx2	EXP		Mouse	PMID:21321602
Cellular Component	GO:0005886	plasma membrane	P2RX2	IDA		Human	PMID:23345450
Cellular Component	GO:0005886	plasma membrane	P2rx2	IDA		Mouse	PMID:17706883
Cellular Component	GO:0005886	plasma membrane	P2rx2	IDA		Rat	PMID:15313628\|RGD:1581703
Cellular Component	GO:0005886	plasma membrane	P2rx2	IDA		Rat	PMID:16388598\|RGD:1642662
Cellular Component	GO:0014069	postsynaptic density	P2rx2	IDA		Rat	PMID:11160443\|RGD:1642669
Cellular Component	GO:0048787	presynaptic active zone membrane	P2rx2	IDA		Rat	PMID:16000618\|RGD:1581702
Cellular Component	GO:0042734	presynaptic membrane	P2rx2	IDA		Rat	PMID:10974431\|RGD:1642670
Cellular Component	GO:0043235	receptor complex	P2RX2	IDA		Human	PMID:15313628
Cellular Component	GO:0043235	receptor complex	P2RX2	IDA		Human	PMID:23382219
Cellular Component	GO:0043235	receptor complex	P2rx2	IDA		Rat	PMID:15313628\|RGD:1581703
Cellular Component	GO:0043195	terminal bouton	P2rx2	IDA		Rat	PMID:10974431\|RGD:1642670
Biological Process	GO:0048266	behavioral response to pain	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:15961431
Biological Process	GO:0048266	behavioral response to pain	P2rx2	IGI	MGI:MGI:1097160	Mouse	PMID:15961431
Biological Process	GO:0007268	chemical synaptic transmission	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:12917379
Biological Process	GO:0003029	detection of hypoxic conditions in blood by carotid body chemoreceptor signaling	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:14672995
Biological Process	GO:0006811	monoatomic ion transport	p2rx2	IGI	ZFIN:ZDB-GENE-000427-3	Zfish	PMID:14580944
Biological Process	GO:0007528	neuromuscular junction development	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:17706883
Biological Process	GO:0007274	neuromuscular synaptic transmission	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:12937291
Biological Process	GO:0019228	neuronal action potential	P2rx2	IMP		Rat	PMID:15317863\|RGD:1642666
Biological Process	GO:0019228	neuronal action potential	P2rx2	IDA		Rat	PMID:16190872\|RGD:1642665
Biological Process	GO:0019228	neuronal action potential	P2rx2	IDA		Rat	PMID:16934235\|RGD:1642659
Biological Process	GO:0030432	peristalsis	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:12937291
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	P2rx2	EXP		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	P2rx2	IDA		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	P2rx2	IEP		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	P2rx2	EXP		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	P2rx2	IDA		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	P2rx2	IEP		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:0033198	response to ATP	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:15961431
Biological Process	GO:0033198	response to ATP	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:15572362
Biological Process	GO:0033198	response to ATP	P2rx2	IGI	MGI:MGI:1097160	Mouse	PMID:15961431
Biological Process	GO:0009743	response to carbohydrate	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:16322458
Biological Process	GO:0001666	response to hypoxia	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:14672995
Biological Process	GO:0002931	response to ischemia	P2rx2	IMP		Rat	PMID:12849743\|RGD:13673769
Biological Process	GO:0014070	response to organic cyclic compound	P2rx2	IDA		Rat	PMID:16388598\|RGD:1642662
Biological Process	GO:0010033	response to organic substance	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:12937291
Biological Process	GO:0007605	sensory perception of sound	P2RX2	IMP		Human	PMID:23345450
Biological Process	GO:0007605	sensory perception of sound	P2rx2	IMP		Mouse	MGI:MGI:5473448\|PMID:23345450
Biological Process	GO:0050909	sensory perception of taste	P2rx2	IGI	MGI:MGI:1097160	Mouse	PMID:16322458
Biological Process	GO:0048741	skeletal muscle fiber development	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:17706883
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	P2rx2	IMP	MGI:MGI:2687349	Mouse	PMID:15961431
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	P2rx2	IGI	MGI:MGI:1097160	Mouse	PMID:15961431

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.