Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse P2rx3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes P2RX3
- Mouse genes P2rx3
- Rat genes P2rx3
- Zfish genes p2rx3a,p2rx3b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set P2rx3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	P2RX3	IDA		Human	PMID:27626375
Molecular Function	GO:0005524	ATP binding	P2rx3	IDA		Rat	PMID:12581826\|RGD:1642675
Molecular Function	GO:0005524	ATP binding	P2rx3	IDA		Rat	PMID:16934235\|RGD:1642659
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2RX3	IDA		Human	PMID:27626375
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx3	IGI	MGI:MGI:2665170	Mouse	PMID:15081800
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx3	IDA		Rat	PMID:12581826\|RGD:1642675
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx3	IDA		Rat	PMID:16934235\|RGD:1642659
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx3	IDA		Rat	PMID:7566119\|RGD:729168
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx3a	IDA		Zfish	PMID:10987841
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx3a	IDA		Zfish	PMID:10869573
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx3a	IGI	RefSeq:NM_053656	Zfish	PMID:10869573
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx3a	IDA		Zfish	PMID:14580944
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx3a	IGI	ZFIN:ZDB-GENE-030319-2	Zfish	PMID:14580944
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx3b	IDA		Zfish	PMID:14580944
Molecular Function	GO:0042802	identical protein binding	P2rx3	IPI	RGD:620253	Rat	PMID:15313628\|RGD:1581703
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	P2RX3	IDA		Human	PMID:27626375
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	P2rx3	IDA		Rat	PMID:7566119\|RGD:729168
Cellular Component	GO:0030424	axon	P2rx3	IDA		Mouse	PMID:11466438
Cellular Component	GO:0030424	axon	P2rx3	IDA		Mouse	PMID:24378336
Cellular Component	GO:0043197	dendritic spine	P2rx3	IDA		Rat	PMID:9721930\|RGD:1642677
Cellular Component	GO:0005794	Golgi apparatus	P2rx3	IDA		Rat	PMID:9721930\|RGD:1642677
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	P2rx3	IDA		Mouse	PMID:17074061
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	P2rx3	IMP		Mouse	PMID:17074061
Cellular Component	GO:0016020	membrane	P2rx3	IDA		Rat	PMID:15139024\|RGD:1642673
Cellular Component	GO:0045121	membrane raft	P2rx3	IDA		Rat	PMID:15139024\|RGD:1642673
Cellular Component	GO:0043005	neuron projection	P2rx3	IDA		Mouse	PMID:11466438
Cellular Component	GO:0043005	neuron projection	P2rx3	IDA		Rat	PMID:11257422\|RGD:1642676
Cellular Component	GO:0043005	neuron projection	P2rx3	IDA		Rat	PMID:16018975\|RGD:1642692
Cellular Component	GO:0043005	neuron projection	P2rx3	IDA		Rat	PMID:9721930\|RGD:1642677
Cellular Component	GO:0043025	neuronal cell body	P2rx3	IDA		Rat	PMID:9721930\|RGD:1642677
Cellular Component	GO:0005886	plasma membrane	P2RX3	IMP		Human	PMID:27626375
Cellular Component	GO:0005886	plasma membrane	P2rx3	IMP		Rat	PMID:7566119\|RGD:729168
Cellular Component	GO:0042734	presynaptic membrane	P2rx3	IDA		Rat	PMID:26801076\|RGD:13702236
Cellular Component	GO:0043235	receptor complex	P2RX3	IDA		Human	PMID:23382219
Cellular Component	GO:0005791	rough endoplasmic reticulum	P2rx3	IDA		Rat	PMID:9721930\|RGD:1642677
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	P2rx3	IMP		Mouse	PMID:17074061
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	P2rx3	IDA		Mouse	PMID:17074061
Cellular Component	GO:0043195	terminal bouton	P2rx3	IDA		Rat	PMID:16018975\|RGD:1642692
Cellular Component	GO:0043195	terminal bouton	P2rx3	IDA		Rat	PMID:9721930\|RGD:1642677
Biological Process	GO:0061368	behavioral response to formalin induced pain	P2rx3	IMP		Rat	PMID:24120766\|RGD:10043614
Biological Process	GO:0048266	behavioral response to pain	P2rx3	IMP	MGI:MGI:2385840	Mouse	PMID:11069182
Biological Process	GO:0048266	behavioral response to pain	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:11069181
Biological Process	GO:0048266	behavioral response to pain	P2rx3	IGI	MGI:MGI:2665170	Mouse	PMID:15961431
Biological Process	GO:0071318	cellular response to ATP	P2RX3	IDA		Human	PMID:27626375
Biological Process	GO:0071318	cellular response to ATP	P2rx3	IDA		Rat	PMID:7566119\|RGD:729168
Biological Process	GO:0007268	chemical synaptic transmission	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:17074061
Biological Process	GO:0051649	establishment of localization in cell	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:11069181
Biological Process	GO:0051649	establishment of localization in cell	P2rx3	IMP	MGI:MGI:2385840	Mouse	PMID:11069182
Biological Process	GO:0060079	excitatory postsynaptic potential	p2rx3b	IDA		Zfish	PMID:14580944\|ZFIN:ZDB-PUB-031031-8
Biological Process	GO:0098662	inorganic cation transmembrane transport	P2RX3	IDA		Human	PMID:27626375
Biological Process	GO:0050804	modulation of chemical synaptic transmission	P2rx3	IMP		Mouse	PMID:17074061
Biological Process	GO:0050804	modulation of chemical synaptic transmission	P2rx3	IDA		Mouse	PMID:17074061
Biological Process	GO:0098655	monoatomic cation transmembrane transport	p2rx3b	IDA		Zfish	PMID:14580944\|ZFIN:ZDB-PUB-031031-8
Biological Process	GO:0006812	monoatomic cation transport	P2rx3	IMP	MGI:MGI:2385840	Mouse	PMID:11069182
Biological Process	GO:0006812	monoatomic cation transport	p2rx3a	IDA		Zfish	PMID:10987841
Biological Process	GO:0006812	monoatomic cation transport	p2rx3a	IGI	ZFIN:ZDB-GENE-030319-2	Zfish	PMID:14580944
Biological Process	GO:0006812	monoatomic cation transport	p2rx3a	IDA		Zfish	PMID:14580944
Biological Process	GO:0006812	monoatomic cation transport	p2rx3a	IDA		Zfish	PMID:10869573
Biological Process	GO:0006812	monoatomic cation transport	p2rx3b	IDA		Zfish	PMID:14580944
Biological Process	GO:0006811	monoatomic ion transport	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:11069181
Biological Process	GO:0022008	neurogenesis	p2rx3a	IMP	ZFIN:ZDB-MRPHLNO-100512-1	Zfish	PMID:19529983
Biological Process	GO:0007274	neuromuscular synaptic transmission	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:12813150
Biological Process	GO:0019228	neuronal action potential	P2rx3	IDA		Rat	PMID:12581826\|RGD:1642675
Biological Process	GO:0019228	neuronal action potential	P2rx3	IDA		Rat	PMID:16934235\|RGD:1642659
Biological Process	GO:0030432	peristalsis	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:12813150
Biological Process	GO:1904058	positive regulation of sensory perception of pain	P2rx3	IMP		Rat	PMID:24120766\|RGD:10043614
Biological Process	GO:0070207	protein homotrimerization	P2RX3	IDA		Human	PMID:27626375
Biological Process	GO:0048167	regulation of synaptic plasticity	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:17074061
Biological Process	GO:0033198	response to ATP	P2rx3	IGI	MGI:MGI:2665170	Mouse	PMID:15961431
Biological Process	GO:0033198	response to ATP	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:12813150
Biological Process	GO:0033198	response to ATP	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:11466438
Biological Process	GO:0033198	response to ATP	P2rx3	IMP	MGI:MGI:2385840	Mouse	PMID:11069182
Biological Process	GO:0033198	response to ATP	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:11069181
Biological Process	GO:0033198	response to ATP	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:17074061
Biological Process	GO:0009743	response to carbohydrate	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:16322458
Biological Process	GO:0009409	response to cold	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:15927378
Biological Process	GO:0009408	response to heat	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:15927378
Biological Process	GO:0001666	response to hypoxia	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:14672995
Biological Process	GO:0009612	response to mechanical stimulus	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:11466438
Biological Process	GO:0010033	response to organic substance	P2rx3	IMP	MGI:MGI:2385840	Mouse	PMID:11069182
Biological Process	GO:0010033	response to organic substance	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:11069181
Biological Process	GO:0009266	response to temperature stimulus	P2rx3	IMP	MGI:MGI:2385840	Mouse	PMID:11069182
Biological Process	GO:0050909	sensory perception of taste	P2rx3	IGI	MGI:MGI:2665170	Mouse	PMID:16322458
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:15961431
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	P2rx3	IGI	MGI:MGI:2665170	Mouse	PMID:15961431
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	P2rx3	IMP	MGI:MGI:1934019	Mouse	PMID:11069181

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.