Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse P2rx4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes P2RX4
- Mouse genes P2rx4
- Rat genes P2rx4
- Zfish genes p2rx4a,p2rx4b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set P2rx4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	P2rx4	IDA		Rat	PMID:12819199\|RGD:1642695
Molecular Function	GO:0005524	ATP binding	P2rx4	IDA		Rat	PMID:16934235\|RGD:1642659
Molecular Function	GO:0005524	ATP binding	p2rx4a	IDA		Zfish	PMID:27071117
Molecular Function	GO:0005524	ATP binding	p2rx4a	IDA		Zfish	PMID:24082111
Molecular Function	GO:0005524	ATP binding	p2rx4a	IDA		Zfish	PMID:25175421
Molecular Function	GO:0005524	ATP binding	p2rx4a	IDA		Zfish	PMID:24878662
Molecular Function	GO:0005524	ATP binding	p2rx4a	IDA		Zfish	PMID:28332633
Molecular Function	GO:0005524	ATP binding	p2rx4a	IDA		Zfish	PMID:12127972
Molecular Function	GO:0005524	ATP binding	p2rx4a	IDA		Zfish	PMID:22535247
Molecular Function	GO:0035381	ATP-gated ion channel activity	p2rx4a	IDA		Zfish	PMID:31024257
Molecular Function	GO:0045296	cadherin binding	P2RX4	IPI	UniProtKB:P33151	Human	PMID:12088286
Molecular Function	GO:0005507	copper ion binding	P2rx4	IDA		Rat	PMID:12819199\|RGD:1642695
Molecular Function	GO:0002135	CTP binding	p2rx4a	IDA		Zfish	PMID:28332633
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2RX4	IDA		Human	PMID:10515189
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2RX4	IDA		Human	PMID:9016352
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx4	IMP		Mouse	PMID:15081800
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx4	IDA		Rat	PMID:12819199\|RGD:1642695
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx4	IDA		Rat	PMID:16282518\|RGD:1642691
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx4	IDA		Rat	PMID:16934235\|RGD:1642659
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx4	IDA		Rat	PMID:8551329\|RGD:61682
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx4a	IDA		Zfish	PMID:28332633
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx4a	IDA		Zfish	PMID:12127972
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx4a	IDA		Zfish	PMID:25597706
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx4a	IDA		Zfish	PMID:14580944
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx4a	IDA		Zfish	PMID:25175421
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx4b	IDA		Zfish	PMID:14580944
Molecular Function	GO:0042802	identical protein binding	P2RX4	IPI	UniProtKB:Q99571	Human	PMID:9016352
Molecular Function	GO:0042802	identical protein binding	P2rx4	IPI	RGD:62073	Rat	PMID:15313628\|RGD:1581703
Molecular Function	GO:0042802	identical protein binding	P2rx4	IPI	UniProtKB:P51577	Rat	PMID:19419241\|RGD:13432299
Molecular Function	GO:0099604	ligand-gated calcium channel activity	P2RX4	IDA		Human	PMID:9016352
Molecular Function	GO:0099604	ligand-gated calcium channel activity	P2rx4	IMP		Rat	PMID:17299767\|RGD:13673751
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	p2rx4a	IDA		Zfish	PMID:27071117
Molecular Function	GO:0005515	protein binding	P2RX4	IPI	UniProtKB:P26371	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	P2RX4	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	P2RX4	IPI	UniProtKB:Q9NQM4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	P2RX4	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RX4	IPI	UniProtKB:P60328	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RX4	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2rx4	IPI	UniProtKB:P49653	Rat	PMID:24815693\|RGD:8693375
Molecular Function	GO:0017076	purine nucleotide binding	p2rx4a	IDA		Zfish	PMID:25597706
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	P2RX4	IMP		Human	PMID:11606481
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	P2RX4	IDA		Human	PMID:9016352
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	P2rx4	IDA		Rat	PMID:12819199\|RGD:1642695
Molecular Function	GO:0005102	signaling receptor binding	P2rx4	IPI	UniProtKB:Q64663	Rat	PMID:17785580\|RGD:8554639
Molecular Function	GO:0008270	zinc ion binding	P2rx4	IDA		Rat	PMID:12819199\|RGD:1642695
Cellular Component	GO:0045177	apical part of cell	P2rx4	IDA		Mouse	PMID:17560948
Cellular Component	GO:0030424	axon	P2rx4	IDA		Rat	PMID:15476696\|RGD:1642694
Cellular Component	GO:0044297	cell body	P2rx4	IDA		Rat	PMID:12849743\|RGD:13673769
Cellular Component	GO:0030054	cell junction	P2RX4	IDA		Human	PMID:12088286
Cellular Component	GO:0030425	dendrite	P2rx4	IDA		Rat	PMID:15476696\|RGD:1642694
Cellular Component	GO:0043197	dendritic spine	P2rx4	IDA		Rat	PMID:11160443\|RGD:1642669
Cellular Component	GO:0070062	extracellular exosome	P2RX4	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	P2RX4	HDA		Human	PMID:23533145
Cellular Component	GO:0005765	lysosomal membrane	P2RX4	HDA		Human	PMID:17897319
Cellular Component	GO:0016020	membrane	P2RX4	IDA		Human	PMID:17785580
Cellular Component	GO:0016020	membrane	P2RX4	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	p2rx4a	IDA		Zfish	PMID:27071117
Cellular Component	GO:0016020	membrane	p2rx4a	IDA		Zfish	PMID:22535247
Cellular Component	GO:0016020	membrane	p2rx4a	IDA		Zfish	PMID:24082111
Cellular Component	GO:0034702	monoatomic ion channel complex	p2rx4a	IDA		Zfish	PMID:22535247
Cellular Component	GO:0043025	neuronal cell body	P2rx4	IDA		Rat	PMID:11160443\|RGD:1642669
Cellular Component	GO:0043025	neuronal cell body	P2rx4	IDA		Rat	PMID:15476696\|RGD:1642694
Cellular Component	GO:0048471	perinuclear region of cytoplasm	P2RX4	IDA		Human	PMID:12088286
Cellular Component	GO:0005886	plasma membrane	P2RX4	IMP		Human	PMID:10515189
Cellular Component	GO:0005886	plasma membrane	P2RX4	IDA		Human	PMID:23303206
Cellular Component	GO:0005886	plasma membrane	P2rx4	IDA		Rat	PMID:17785580\|RGD:8554639
Cellular Component	GO:0005886	plasma membrane	P2rx4	IMP		Rat	PMID:8551329\|RGD:61682
Cellular Component	GO:0014069	postsynaptic density	P2rx4	IDA		Rat	PMID:11160443\|RGD:1642669
Cellular Component	GO:0014069	postsynaptic density	P2rx4	IDA		Rat	PMID:15476696\|RGD:1642694
Cellular Component	GO:0045202	synapse	P2rx4	IDA		Rat	PMID:15476696\|RGD:1642694
Cellular Component	GO:0043195	terminal bouton	P2rx4	IDA		Rat	PMID:15476696\|RGD:1642694
Cellular Component	GO:1902495	transmembrane transporter complex	p2rx4a	IDA		Zfish	PMID:25597706
Biological Process	GO:0097190	apoptotic signaling pathway	P2RX4	IDA		Human	PMID:17264311
Biological Process	GO:0048266	behavioral response to pain	P2rx4	IMP		Rat	PMID:12917686\|RGD:13673840
Biological Process	GO:0070588	calcium ion transmembrane transport	P2RX4	IDA		Human	PMID:9016352
Biological Process	GO:0070588	calcium ion transmembrane transport	P2rx4	IDA		Rat	PMID:8551329\|RGD:61682
Biological Process	GO:0006816	calcium ion transport	P2rx4	IMP	MGI:MGI:3612982	Mouse	PMID:16327800
Biological Process	GO:0006816	calcium ion transport	p2rx4a	IDA		Zfish	PMID:25597706
Biological Process	GO:0071318	cellular response to ATP	P2RX4	IDA		Human	PMID:10515189
Biological Process	GO:0071318	cellular response to ATP	P2rx4	IDA		Rat	PMID:8551329\|RGD:61682
Biological Process	GO:0071294	cellular response to zinc ion	P2rx4	IDA		Rat	PMID:8551329\|RGD:61682
Biological Process	GO:0060079	excitatory postsynaptic potential	P2rx4	IMP	MGI:MGI:3665297	Mouse	PMID:16943557
Biological Process	GO:0098662	inorganic cation transmembrane transport	P2rx4	IDA		Rat	PMID:16282518\|RGD:1642691
Biological Process	GO:0051899	membrane depolarization	P2RX4	IDA		Human	PMID:9016352
Biological Process	GO:0006812	monoatomic cation transport	p2rx4a	IDA		Zfish	PMID:14580944
Biological Process	GO:0006812	monoatomic cation transport	p2rx4a	IDA		Zfish	PMID:12127972
Biological Process	GO:0006812	monoatomic cation transport	p2rx4b	IDA		Zfish	PMID:14580944
Biological Process	GO:0034220	monoatomic ion transmembrane transport	P2RX4	IDA		Human	PMID:10515189
Biological Process	GO:0010614	negative regulation of cardiac muscle hypertrophy	P2RX4	IMP		Human	PMID:15130891
Biological Process	GO:0019228	neuronal action potential	P2rx4	IDA		Rat	PMID:12819199\|RGD:1642695
Biological Process	GO:0019228	neuronal action potential	P2rx4	IDA		Rat	PMID:16934235\|RGD:1642659
Biological Process	GO:0006809	nitric oxide biosynthetic process	P2rx4	IDA		Mouse	PMID:16327800
Biological Process	GO:0006809	nitric oxide biosynthetic process	P2rx4	IMP	MGI:MGI:3612982	Mouse	PMID:16327800
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	P2RX4	IMP		Human	PMID:21106936
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	P2RX4	IMP		Human	PMID:10899068
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	P2RX4	IDA		Human	PMID:10969036
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	P2RX4	IMP		Human	PMID:10899068
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	P2RX4	IDA		Human	PMID:10969036
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis	P2RX4	IMP		Human	PMID:21106936
Biological Process	GO:1904141	positive regulation of microglial cell migration	P2rx4	IMP		Rat	PMID:17299767\|RGD:13673751
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	P2rx4	IMP		Rat	PMID:17299767\|RGD:13673751
Biological Process	GO:0035590	purinergic nucleotide receptor signaling pathway	P2RX4	IMP		Human	PMID:11606481
Biological Process	GO:0008217	regulation of blood pressure	P2RX4	IMP		Human	PMID:11606481
Biological Process	GO:0008217	regulation of blood pressure	P2RX4	IMP		Human	PMID:15130891
Biological Process	GO:0055117	regulation of cardiac muscle contraction	P2RX4	IMP		Human	PMID:11606481
Biological Process	GO:0055117	regulation of cardiac muscle contraction	P2RX4	IMP		Human	PMID:15130891
Biological Process	GO:0050920	regulation of chemotaxis	P2rx4	IMP		Rat	PMID:17299767\|RGD:13673751
Biological Process	GO:0002028	regulation of sodium ion transport	P2rx4	IDA		Rat	PMID:17785580\|RGD:8554639
Biological Process	GO:0055119	relaxation of cardiac muscle	P2RX4	IMP		Human	PMID:11606481
Biological Process	GO:0055119	relaxation of cardiac muscle	P2RX4	IMP		Human	PMID:15130891
Biological Process	GO:0033198	response to ATP	P2RX4	IDA		Human	PMID:9016352
Biological Process	GO:0048678	response to axon injury	P2rx4	IMP		Rat	PMID:12917686\|RGD:13673840
Biological Process	GO:0034405	response to fluid shear stress	P2RX4	IDA		Human	PMID:10969036
Biological Process	GO:0002931	response to ischemia	P2rx4	IMP		Rat	PMID:12849743\|RGD:13673769
Biological Process	GO:0019233	sensory perception of pain	P2rx4	IMP		Rat	PMID:12917686\|RGD:13673840
Biological Process	GO:0019233	sensory perception of pain	P2rx4	IMP		Rat	PMID:14978347\|RGD:8553355
Biological Process	GO:0050975	sensory perception of touch	P2rx4	IMP		Rat	PMID:12917686\|RGD:13673840
Biological Process	GO:0007165	signal transduction	P2RX4	IDA		Human	PMID:9016352
Biological Process	GO:0042311	vasodilation	P2rx4	IMP	MGI:MGI:3612982	Mouse	PMID:16327800

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.