Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse P2ry1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes P2RY1
- Mouse genes P2ry1
- Rat genes P2ry1
- Zfish genes p2ry1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set P2ry1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031686	A1 adenosine receptor binding	P2ry1	IPI	UniProtKB:P25099	Rat	PMID:11390975\|RGD:8553380
Molecular Function	GO:0043531	ADP binding	P2ry1	IDA		Rat	PMID:15152027\|RGD:1642805
Molecular Function	GO:0005524	ATP binding	P2RY1	IMP		Human	PMID:25822790
Molecular Function	GO:0005524	ATP binding	P2ry1	IDA		Rat	PMID:11557527\|RGD:628452
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	P2RY1	IMP		Human	PMID:9442040
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Molecular Function	GO:0045031	G protein-coupled ATP receptor activity	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Molecular Function	GO:0045028	G protein-coupled purinergic nucleotide receptor activity	P2ry1	IDA		Rat	PMID:15152027\|RGD:1642805
Molecular Function	GO:0045028	G protein-coupled purinergic nucleotide receptor activity	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Molecular Function	GO:0005515	protein binding	P2RY1	IPI	UniProtKB:O14745	Human	PMID:9671706
Molecular Function	GO:0046982	protein heterodimerization activity	P2ry1	IPI	UniProtKB:P25099	Rat	PMID:11390975\|RGD:8553380
Molecular Function	GO:0097110	scaffold protein binding	P2ry1	IPI	UniProtKB:P31016	Rat	PMID:20847060\|RGD:8554370
Cellular Component	GO:0016324	apical plasma membrane	P2ry1	IDA		Rat	PMID:11557527\|RGD:628452
Cellular Component	GO:0016323	basolateral plasma membrane	P2ry1	IDA		Rat	PMID:11557527\|RGD:628452
Cellular Component	GO:0044297	cell body	P2ry1	IDA		Rat	PMID:12417330\|RGD:8554816
Cellular Component	GO:0044297	cell body	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Cellular Component	GO:0009986	cell surface	P2RY1	HDA		Human	PMID:23382103
Cellular Component	GO:0005929	cilium	P2RY1	IDA		Human	PMID:28154160
Cellular Component	GO:0030425	dendrite	P2ry1	IDA		Rat	PMID:12417330\|RGD:8554816
Cellular Component	GO:0030425	dendrite	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Cellular Component	GO:0098978	glutamatergic synapse	P2ry1	EXP		Rat	PMID:16000618\|RGD:1581702
Cellular Component	GO:0098978	glutamatergic synapse	P2ry1	IDA		Rat	PMID:16000618\|RGD:1581702
Cellular Component	GO:0005739	mitochondrion	P2ry1	IDA		Rat	PMID:17292801\|RGD:2315830
Cellular Component	GO:0005886	plasma membrane	P2RY1	IDA		Human	PMID:25822790
Cellular Component	GO:0005886	plasma membrane	P2ry1	IDA		Mouse	PMID:15670583
Cellular Component	GO:0005886	plasma membrane	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Cellular Component	GO:0014069	postsynaptic density	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Cellular Component	GO:0045211	postsynaptic membrane	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Cellular Component	GO:0048787	presynaptic active zone membrane	P2ry1	IDA		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	P2ry1	IDA		Rat	PMID:11390975\|RGD:8553380
Biological Process	GO:0007568	aging	P2ry1	IEP		Rat	PMID:11738148\|RGD:2316735
Biological Process	GO:0097746	blood vessel diameter maintenance	P2ry1	IMP		Rat	PMID:12730558\|RGD:2316708
Biological Process	GO:0071407	cellular response to organic cyclic compound	P2ry1	IDA		Mouse	PMID:23479225
Biological Process	GO:0071415	cellular response to purine-containing compound	P2RY1	IMP		Human	PMID:9442040
Biological Process	GO:0042755	eating behavior	P2ry1	IMP		Rat	PMID:17067301\|RGD:2315831
Biological Process	GO:0051649	establishment of localization in cell	P2ry1	IGI	MGI:MGI:1918089	Mouse	PMID:15914557
Biological Process	GO:0051649	establishment of localization in cell	P2ry1	IMP	MGI:MGI:2181709	Mouse	PMID:15914557
Biological Process	GO:0051649	establishment of localization in cell	P2ry1	IGI	MGI:MGI:1098235	Mouse	PMID:15914557
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Biological Process	GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	P2ry1	IDA		Rat	PMID:15152027\|RGD:1642805
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Biological Process	GO:0008347	glial cell migration	P2ry1	IMP		Rat	PMID:20681951\|RGD:8693681
Biological Process	GO:0006811	monoatomic ion transport	P2ry1	IGI	MGI:MGI:1098235	Mouse	PMID:15914557
Biological Process	GO:0006811	monoatomic ion transport	P2ry1	IGI	MGI:MGI:1918089	Mouse	PMID:15914557
Biological Process	GO:0006811	monoatomic ion transport	P2ry1	IMP	MGI:MGI:2181709	Mouse	PMID:15914557
Biological Process	GO:0051100	negative regulation of binding	P2ry1	IDA		Rat	PMID:11390975\|RGD:8553380
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	P2ry1	IDA		Rat	PMID:19447154\|RGD:2315789
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	P2RY1	IMP		Human	PMID:9442040
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	P2ry1	IMP		Rat	PMID:19373936\|RGD:2315808
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Biological Process	GO:0046887	positive regulation of hormone secretion	P2ry1	IDA		Rat	PMID:19515986\|RGD:2315760
Biological Process	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process	P2ry1	IDA		Rat	PMID:11390975\|RGD:8553380
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	P2ry1	IGI	MGI:MGI:1098235	Mouse	PMID:15914557
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	P2ry1	IGI	MGI:MGI:1918089	Mouse	PMID:15914557
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	P2ry1	IMP	MGI:MGI:2181709	Mouse	PMID:15914557
Biological Process	GO:0060406	positive regulation of penile erection	P2ry1	IDA		Rat	PMID:19303093\|RGD:2315809
Biological Process	GO:0001934	positive regulation of protein phosphorylation	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Biological Process	GO:0072659	protein localization to plasma membrane	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Biological Process	GO:0008360	regulation of cell shape	P2RY1	IMP		Human	PMID:9442040
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	P2ry1	EXP		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	P2ry1	IDA		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	P2ry1	IEP		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:0010469	regulation of signaling receptor activity	P2ry1	IDA		Rat	PMID:11390975\|RGD:8553380
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	P2ry1	EXP		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	P2ry1	IDA		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	P2ry1	IEP		Rat	PMID:16000618\|RGD:1581702
Biological Process	GO:0070848	response to growth factor	P2ry1	IEP		Rat	PMID:14714568\|RGD:2316690
Biological Process	GO:0009612	response to mechanical stimulus	P2ry1	IMP		Rat	PMID:14689471\|RGD:2316692
Biological Process	GO:0019233	sensory perception of pain	P2ry1	IDA		Rat	PMID:15740803\|RGD:2316686
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	P2ry1	IDA		Rat	PMID:20847060\|RGD:8554370
Biological Process	GO:0042060	wound healing	P2ry1	IEP		Rat	PMID:14714568\|RGD:2316690

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.