Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse P2ry12

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes P2RY12
- Mouse genes P2ry12
- Rat genes P2ry12
- Zfish genes p2ry12
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set P2ry12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	P2ry12	IMP	MGI:MGI:2445936	Mouse	PMID:11413167
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	P2RY12	IDA		Human	PMID:11104774
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	P2RY12	IMP		Human	PMID:12578987
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	P2ry12	IMP	MGI:MGI:2445936	Mouse	PMID:11413167
Molecular Function	GO:0001621	G protein-coupled ADP receptor activity	P2ry12	IDA		Rat	PMID:11196645\|RGD:633493
Cellular Component	GO:0009925	basal plasma membrane	P2ry12	IDA		Rat	PMID:21879346\|RGD:6480539
Cellular Component	GO:0005901	caveola	P2ry12	IDA		Rat	PMID:21879346\|RGD:6480539
Cellular Component	GO:0044298	cell body membrane	P2ry12	IGI	UniProtKB:Q9Z0D9	Mouse	MGI:MGI:5806217\|PMID:26948129
Cellular Component	GO:0031253	cell projection membrane	P2ry12	IGI	UniProtKB:Q9Z0D9	Mouse	MGI:MGI:5806217\|PMID:26948129
Cellular Component	GO:0009986	cell surface	P2RY12	HDA		Human	PMID:23382103
Cellular Component	GO:0009897	external side of plasma membrane	P2ry12	IDA		Rat	PMID:11196645\|RGD:633493
Cellular Component	GO:0016020	membrane	P2RY12	IDA		Human	PMID:12578987
Cellular Component	GO:0005739	mitochondrion	P2ry12	IDA		Rat	PMID:17292801\|RGD:2315830
Cellular Component	GO:0005886	plasma membrane	P2ry12	IDA		Mouse	MGI:MGI:3693016\|PMID:17115040
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	P2RY12	IMP		Human	PMID:12578987
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	P2ry12	IMP	MGI:MGI:2445936	Mouse	PMID:11413167
Biological Process	GO:0070588	calcium ion transmembrane transport	P2ry12	IDA		Rat	PMID:12080041\|RGD:625482
Biological Process	GO:0019722	calcium-mediated signaling	P2ry12	IMP		Rat	PMID:18183622\|RGD:13673786
Biological Process	GO:0035585	calcium-mediated signaling using extracellular calcium source	P2ry12	IMP		Rat	PMID:17299767\|RGD:13673751
Biological Process	GO:0030030	cell projection organization	P2ry12	IMP		Rat	PMID:20091784\|RGD:6480646
Biological Process	GO:0071318	cellular response to ATP	P2ry12	IMP		Mouse	MGI:MGI:3693016\|PMID:17115040
Biological Process	GO:0071318	cellular response to ATP	P2ry12	IMP		Rat	PMID:20091784\|RGD:6480646
Biological Process	GO:0071407	cellular response to organic cyclic compound	P2ry12	IDA		Mouse	PMID:23479225
Biological Process	GO:0021808	cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration	P2ry12	IMP		Rat	PMID:17299767\|RGD:13673751
Biological Process	GO:0021808	cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration	P2ry12	IMP		Rat	PMID:18183622\|RGD:13673786
Biological Process	GO:0051649	establishment of localization in cell	P2ry12	IGI	MGI:MGI:105049	Mouse	PMID:15914557
Biological Process	GO:0051649	establishment of localization in cell	P2ry12	IGI	MGI:MGI:1098235	Mouse	PMID:15914557
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	P2ry12	IMP		Rat	PMID:12814667\|RGD:6482299
Biological Process	GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway	P2ry12	IMP	MGI:MGI:2445936	Mouse	MGI:MGI:2136079\|PMID:11413167
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	P2RY12	IDA		Human	PMID:11104774
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	P2ry12	IMP	MGI:MGI:2445936	Mouse	MGI:MGI:2136079\|PMID:11413167
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	P2ry12	IMP		Rat	PMID:11196645\|RGD:633493
Biological Process	GO:0008347	glial cell migration	P2ry12	IMP		Rat	PMID:20681951\|RGD:8693681
Biological Process	GO:0030032	lamellipodium assembly	P2ry12	IMP		Rat	PMID:20091784\|RGD:6480646
Biological Process	GO:0001774	microglial cell activation	p2ry12	IMP		Zfish	PMID:22632801
Biological Process	GO:0001774	microglial cell activation	p2ry12	IMP	ZFIN:ZDB-MRPHLNO-121109-1	Zfish	PMID:22632801
Biological Process	GO:0006811	monoatomic ion transport	P2ry12	IGI	MGI:MGI:105049	Mouse	PMID:15914557
Biological Process	GO:0006811	monoatomic ion transport	P2ry12	IGI	MGI:MGI:1098235	Mouse	PMID:15914557
Biological Process	GO:0045596	negative regulation of cell differentiation	P2ry12	IMP		Rat	PMID:15056287\|RGD:1580185
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	P2ry12	IMP		Rat	PMID:19447154\|RGD:2315789
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	P2ry12	IMP		Rat	PMID:18183622\|RGD:13673786
Biological Process	GO:0030168	platelet activation	P2ry12	IMP	MGI:MGI:2445936	Mouse	PMID:11413167
Biological Process	GO:0070527	platelet aggregation	P2RY12	IMP		Human	PMID:12578987
Biological Process	GO:0070527	platelet aggregation	P2ry12	IMP		Rat	PMID:19028049\|RGD:6480528
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	P2ry12	IGI	UniProtKB:P49134	Rat	PMID:20091784\|RGD:6480646
Biological Process	GO:0050921	positive regulation of chemotaxis	P2ry12	IMP		Rat	PMID:18183622\|RGD:13673786
Biological Process	GO:0033626	positive regulation of integrin activation by cell surface receptor linked signal transduction	P2ry12	IDA		Rat	PMID:20091784\|RGD:6480646
Biological Process	GO:1904141	positive regulation of microglial cell migration	P2ry12	IMP		Rat	PMID:17299767\|RGD:13673751
Biological Process	GO:1904141	positive regulation of microglial cell migration	P2ry12	IMP		Rat	PMID:18183622\|RGD:13673786
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	P2ry12	IGI	MGI:MGI:105049	Mouse	PMID:15914557
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	P2ry12	IGI	MGI:MGI:1098235	Mouse	PMID:15914557
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	P2ry12	IMP		Rat	PMID:17299767\|RGD:13673751
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	P2ry12	IMP		Rat	PMID:18183622\|RGD:13673786
Biological Process	GO:1900029	positive regulation of ruffle assembly	P2ry12	IMP		Rat	PMID:17299767\|RGD:13673751
Biological Process	GO:0071805	potassium ion transmembrane transport	P2ry12	IDA		Rat	PMID:12080041\|RGD:625482
Biological Process	GO:0043491	protein kinase B signaling	P2ry12	IMP		Rat	PMID:15056287\|RGD:1580185
Biological Process	GO:0051924	regulation of calcium ion transport	P2ry12	IMP		Rat	PMID:15579146\|RGD:6480652
Biological Process	GO:0050920	regulation of chemotaxis	P2ry12	IMP		Rat	PMID:17299767\|RGD:13673751
Biological Process	GO:1904139	regulation of microglial cell migration	P2ry12	IDA		Mouse	MGI:MGI:3693016\|PMID:17115040
Biological Process	GO:0010725	regulation of primitive erythrocyte differentiation	p2ry12	IMP	ZFIN:ZDB-GENO-220922-4	Zfish	PMID:32555443
Biological Process	GO:0010725	regulation of primitive erythrocyte differentiation	p2ry12	IGI	ZFIN:ZDB-GENO-220922-4,ZFIN:ZDB-MRPHLNO-050208-10	Zfish	PMID:32555443
Biological Process	GO:0048678	response to axon injury	P2ry12	IDA		Rat	PMID:14603465\|RGD:13673748
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension	P2ry12	IMP		Mouse	MGI:MGI:3693016\|PMID:17115040
Biological Process	GO:0150063	visual system development	P2ry12	IGI	UniProtKB:Q9Z0D9	Mouse	MGI:MGI:5806217\|PMID:26948129

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.