Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes P2RY2
  • Mouse genes P2ry2
  • Rat genes P2ry2
  • Zfish genes p2ry2.1,p2ry2.2,p2ry2.3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set P2ry2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031686	A1 adenosine receptor binding	P2ry2	IPI	UniProtKB:P25099	Rat	PMID:11390975|RGD:8553380
Molecular Function	GO:0005524	ATP binding	P2ry2	IDA		Rat	PMID:11557527|RGD:628452
Molecular Function	GO:0045030	G protein-coupled UTP receptor activity	P2ry2	IDA		Rat	PMID:15924261|RGD:2316682
Molecular Function	GO:0005515	protein binding	P2RY2	IPI	UniProtKB:Q8WUW1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P2ry2	IPI	UniProtKB:P25099	Rat	PMID:11390975|RGD:8553380
Cellular Component	GO:0016324	apical plasma membrane	P2ry2	IDA		Rat	PMID:11557527|RGD:628452
Cellular Component	GO:0016323	basolateral plasma membrane	P2ry2	IDA		Rat	PMID:11557527|RGD:628452
Cellular Component	GO:0005769	early endosome	P2ry2	IDA		Rat	PMID:15924261|RGD:2316682
Cellular Component	GO:0098978	glutamatergic synapse	P2ry2	EXP		Rat	PMID:16000618|RGD:1581702
Cellular Component	GO:0098978	glutamatergic synapse	P2ry2	IDA		Rat	PMID:16000618|RGD:1581702
Cellular Component	GO:0005764	lysosome	P2ry2	IDA		Rat	PMID:15924261|RGD:2316682
Cellular Component	GO:0005739	mitochondrion	P2ry2	IDA		Rat	PMID:17292801|RGD:2315830
Cellular Component	GO:0048787	presynaptic active zone membrane	P2ry2	IDA		Rat	PMID:16000618|RGD:1581702
Biological Process	GO:0007568	aging	P2ry2	IEP		Rat	PMID:11738148|RGD:2316735
Biological Process	GO:0097746	blood vessel diameter maintenance	P2ry2	IDA		Rat	PMID:12730558|RGD:2316708
Biological Process	GO:0071347	cellular response to interleukin-1	P2ry2	IEP		Rat	PMID:19317852|RGD:2316656
Biological Process	GO:0071222	cellular response to lipopolysaccharide	P2ry2	IEP		Rat	PMID:18689605|RGD:2316659
Biological Process	GO:0071415	cellular response to purine-containing compound	P2ry2	IEP		Rat	PMID:16831297|RGD:2316681
Biological Process	GO:0051649	establishment of localization in cell	P2ry2	IMP	MGI:MGI:3613160	Mouse	PMID:17728398
Biological Process	GO:0001701	in utero embryonic development	P2ry2	IEP		Rat	PMID:14517997|RGD:2316694
Biological Process	GO:0070254	mucus secretion	P2ry2	IMP	MGI:MGI:3613160	Mouse	PMID:17728398
Biological Process	GO:0030279	negative regulation of ossification	P2ry2	IDA		Rat	PMID:12210747|RGD:729594
Biological Process	GO:0032722	positive regulation of chemokine production	P2ry2	IDA		Rat	PMID:17947675|RGD:2316680
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	P2ry2	IMP		Rat	PMID:19155635|RGD:2316657
Biological Process	GO:0070257	positive regulation of mucus secretion	P2ry2	IMP	MGI:MGI:3613160	Mouse	PMID:17728398
Biological Process	GO:0010976	positive regulation of neuron projection development	P2ry2	IDA		Rat	PMID:15379893|RGD:2316689
Biological Process	GO:0060406	positive regulation of penile erection	P2ry2	IDA		Rat	PMID:19303093|RGD:2315809
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	P2ry2	IDA		Rat	PMID:15840771|RGD:2316683
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	P2ry2	IMP		Rat	PMID:11934835|RGD:727358
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	P2ry2	EXP		Rat	PMID:16000618|RGD:1581702
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	P2ry2	IDA		Rat	PMID:16000618|RGD:1581702
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	P2ry2	IEP		Rat	PMID:16000618|RGD:1581702
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	P2ry2	EXP		Rat	PMID:16000618|RGD:1581702
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	P2ry2	IDA		Rat	PMID:16000618|RGD:1581702
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	P2ry2	IEP		Rat	PMID:16000618|RGD:1581702
Biological Process	GO:0070848	response to growth factor	P2ry2	IEP		Rat	PMID:14714568|RGD:2316690
Biological Process	GO:0019233	sensory perception of pain	P2ry2	IDA		Rat	PMID:15740803|RGD:2316686
Biological Process	GO:0042060	wound healing	P2ry2	IEP		Rat	PMID:14714568|RGD:2316690

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern