Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes P4HB
  • Mouse genes P4hb
  • Rat genes P4hb
  • Zfish genes p4hb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set P4hb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	P4HB	IPI	UniProtKB:P60709	Human	PMID:24415753
Molecular Function	GO:0019899	enzyme binding	P4hb	IPI	RGD:3731	Rat	PMID:23061969|RGD:8655994
Molecular Function	GO:0005178	integrin binding	P4HB	IPI	UniProtKB:P05106	Human	PMID:21670307
Molecular Function	GO:0005178	integrin binding	P4hb	IPI	UniProtKB:O54890	Mouse	MGI:MGI:5014432|PMID:21670307
Molecular Function	GO:0004656	procollagen-proline 4-dioxygenase activity	P4HB	IDA		Human	PMID:7753822
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q9UMX0	Human	PMID:12095988
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P55157	Human	PMID:16478722
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q03518	Human	PMID:17055437
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q8TCT9	Human	PMID:19942855
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q96HE7	Human	PMID:20802462
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q13162	Human	PMID:21057456
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:O00182,UniProtKB:P30101,UniProtKB:Q15084	Human	PMID:21670307
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P55157	Human	PMID:23475612
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q03463:PRO_0000278740	Human	PMID:23861867
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P55157	Human	PMID:25108285
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P55157	Human	PMID:26224785
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P28799	Human	PMID:26370502
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q2GL86	Human	PMID:31992623
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:O94818-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P01137	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P09228	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P26371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P28799	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P60328	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P80188	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q14990	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q52LG2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q5T7P3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q5TA78	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q5TA82	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q63HM9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q6PJG9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q8NE01	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q8NEG0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q92692-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q9BYQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q9BYQ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q9P121-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q9P2K6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q9UC07-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q9ULW2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q9Y6H1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:O00444	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:O15534	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:O43521	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P02538	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P17655	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:P62873	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q09028	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q494V2-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q53R41	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q5T0J7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q86WV1-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q8N4N3-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q8TAB7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q8TAP6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q8WUG5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q96B97	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q96D03	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q96RK4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4HB	IPI	UniProtKB:Q9NU02	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	P4hb	IPI	UniProtKB:B5TVM2	Mouse	MGI:MGI:6707347|PMID:33863978
Molecular Function	GO:0005515	protein binding	P4hb	IPI	UniProtKB:O08573	Mouse	MGI:MGI:5014432|PMID:21670307
Molecular Function	GO:0003756	protein disulfide isomerase activity	P4HB	IDA		Human	PMID:15225124
Molecular Function	GO:0003756	protein disulfide isomerase activity	P4HB	EXP		Human	PMID:15720785
Molecular Function	GO:0003756	protein disulfide isomerase activity	P4HB	IDA		Human	PMID:21091435
Molecular Function	GO:0003756	protein disulfide isomerase activity	P4hb	IMP		Rat	PMID:2841089|RGD:633506
Molecular Function	GO:0046982	protein heterodimerization activity	P4HB	IDA		Human	PMID:23475612
Molecular Function	GO:0044877	protein-containing complex binding	P4hb	IPI	RGD:1308388	Rat	PMID:11830580|RGD:1582567
Molecular Function	GO:0015035	protein-disulfide reductase activity	P4HB	IDA		Human	PMID:16677074
Molecular Function	GO:0015035	protein-disulfide reductase activity	P4HB	EXP		Human	PMID:21308844
Molecular Function	GO:0015035	protein-disulfide reductase activity	P4hb	IMP	MGI:MGI:5504624	Mouse	PMID:31184304
Molecular Function	GO:0003723	RNA binding	P4HB	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	P4HB	HDA		Human	PMID:22681889
Molecular Function	GO:0016972	thiol oxidase activity	P4HB	IDA		Human	PMID:21091435
Cellular Component	GO:0005856	cytoskeleton	P4HB	IDA		Human	PMID:24415753
Cellular Component	GO:0005829	cytosol	P4HB	IDA		Human	PMID:24415753
Cellular Component	GO:0005783	endoplasmic reticulum	P4HB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	P4HB	IDA		Human	PMID:12095988
Cellular Component	GO:0005783	endoplasmic reticulum	P4HB	IDA		Human	PMID:23152784
Cellular Component	GO:0005783	endoplasmic reticulum	P4HB	IDA		Human	PMID:23475612
Cellular Component	GO:0005783	endoplasmic reticulum	P4HB	IDA		Human	PMID:24415753
Cellular Component	GO:0005783	endoplasmic reticulum	P4hb	IDA		Mouse	PMID:28053051
Cellular Component	GO:0005783	endoplasmic reticulum	P4hb	IDA		Mouse	PMID:15767459
Cellular Component	GO:0005783	endoplasmic reticulum	P4hb	IDA		Mouse	PMID:9806833
Cellular Component	GO:0005783	endoplasmic reticulum	P4hb	IDA		Mouse	PMID:14622145
Cellular Component	GO:0005783	endoplasmic reticulum	P4hb	IDA		Mouse	PMID:15767678
Cellular Component	GO:0005783	endoplasmic reticulum	P4hb	IDA		Mouse	PMID:18094359
Cellular Component	GO:0005783	endoplasmic reticulum	P4hb	IDA		Mouse	PMID:9493907
Cellular Component	GO:0034663	endoplasmic reticulum chaperone complex	P4hb	IDA		Mouse	MGI:MGI:5613481|PMID:12475965
Cellular Component	GO:0005788	endoplasmic reticulum lumen	P4hb	IMP	MGI:MGI:5504624	Mouse	PMID:31184304
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	P4HB	IDA		Human	PMID:15308636
Cellular Component	GO:0009897	external side of plasma membrane	P4HB	IDA		Human	PMID:21670307
Cellular Component	GO:0009897	external side of plasma membrane	P4hb	IDA		Mouse	MGI:MGI:5014432|PMID:21670307
Cellular Component	GO:0070062	extracellular exosome	P4HB	HDA		Human	PMID:19199708
Cellular Component	GO:0005925	focal adhesion	P4HB	HDA		Human	PMID:21423176
Cellular Component	GO:0030027	lamellipodium	P4HB	IDA		Human	PMID:24415753
Cellular Component	GO:0016222	procollagen-proline 4-dioxygenase complex	P4HB	IDA		Human	PMID:7753822
Cellular Component	GO:0032991	protein-containing complex	P4HB	IDA		Human	PMID:24415753
Biological Process	GO:0071456	cellular response to hypoxia	P4HB	IMP		Human	PMID:12095988
Biological Process	GO:0098761	cellular response to interleukin-7	P4hb	IDA		Mouse	PMID:29581031
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	P4hb	IMP	MGI:MGI:5504624	Mouse	PMID:31184304
Biological Process	GO:0030070	insulin processing	P4hb	IMP	MGI:MGI:5504624	Mouse	PMID:31184304
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	P4HB	IDA		Human	PMID:7753822
Biological Process	GO:0045785	positive regulation of cell adhesion	P4HB	IMP		Human	PMID:24415753
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	P4HB	IMP		Human	PMID:24415753
Biological Process	GO:0046598	positive regulation of viral entry into host cell	P4HB	IMP		Human	PMID:21670307
Biological Process	GO:0034975	protein folding in endoplasmic reticulum	P4HB	IDA		Human	PMID:21091435
Biological Process	GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	P4HB	IMP		Human	PMID:12095988
Biological Process	GO:0034976	response to endoplasmic reticulum stress	P4HB	IMP		Human	PMID:12095988

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern