Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PACSIN2
  • Mouse genes Pacsin2
  • Rat genes Pacsin2
  • Zfish genes pacsin2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pacsin2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	PACSIN2	HDA		Human	PMID:25468996
Molecular Function	GO:0008092	cytoskeletal protein binding	Pacsin2	IDA		Mouse	PMID:11082044
Molecular Function	GO:0042802	identical protein binding	PACSIN2	IPI	UniProtKB:Q9UNF0	Human	PMID:16189514
Molecular Function	GO:0042802	identical protein binding	PACSIN2	IPI	UniProtKB:Q9UNF0	Human	PMID:20188097
Molecular Function	GO:0042802	identical protein binding	PACSIN2	IPI	UniProtKB:Q9UNF0	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	PACSIN2	IPI	UniProtKB:Q9UNF0	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	PACSIN2	IPI	UniProtKB:Q9UNF0	Human	PMID:32296183
Molecular Function	GO:0008289	lipid binding	Pacsin2	IDA		Mouse	MGI:MGI:4440389|PMID:20188097
Molecular Function	GO:0070300	phosphatidic acid binding	PACSIN2	IDA		Human	PMID:23596323
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q9BY11	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:P48023	Human	PMID:16318909
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:P50570	Human	PMID:16551695
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q9BY11	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:P54274	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:E1BBG2	Human	PMID:23596323
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q5E9R3	Human	PMID:23596323
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q8N3F8	Human	PMID:23596323
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q9H4M9	Human	PMID:23596323
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:O14672	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q9BY11	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q9BY11	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:O00401	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:O15499	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:O75128	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q9BY11	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q9BYU1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q9NPQ8-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PACSIN2	IPI	UniProtKB:Q9UKS6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pacsin2	IPI	PR:Q99JB8	Mouse	PMID:11082044
Molecular Function	GO:0005515	protein binding	Pacsin2	IPI	PR:Q9WVE8	Mouse	PMID:11082044
Molecular Function	GO:0005515	protein binding	Pacsin2	IPI	PR:Q91YD9	Mouse	PMID:11082044
Molecular Function	GO:0005515	protein binding	Pacsin2	IPI	PR:Q61644	Mouse	PMID:11082044
Molecular Function	GO:0005515	protein binding	Pacsin2	IPI	UniProtKB:Q641Z6	Rat	PMID:15371016|RGD:8554498
Molecular Function	GO:0005515	protein binding	Pacsin2	IPI	UniProtKB:Q9EQP2	Rat	PMID:15371016|RGD:8554498
Molecular Function	GO:0005515	protein binding	Pacsin2	IPI	UniProtKB:P18545	Rat	PMID:16357825|RGD:8554657
Molecular Function	GO:0005515	protein binding	Pacsin2	IPI	UniProtKB:Q9NZQ3	Rat	PMID:16999739|RGD:8553470
Molecular Function	GO:0005515	protein binding	Pacsin2	IPI	UniProtKB:Q5NBX1	Rat	PMID:21725280|RGD:8554579
Cellular Component	GO:0005901	caveola	PACSIN2	IDA		Human	PMID:21610094
Cellular Component	GO:0005901	caveola	PACSIN2	IDA		Human	PMID:24013648
Cellular Component	GO:0005901	caveola	Pacsin2	IDA		Mouse	MGI:MGI:5317398|PMID:21610094
Cellular Component	GO:0005911	cell-cell junction	Pacsin2	IDA		Mouse	PMID:23793062
Cellular Component	GO:0034451	centriolar satellite	PACSIN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	Pacsin2	IDA		Mouse	PMID:11082044
Cellular Component	GO:0005829	cytosol	Pacsin2	IDA		Mouse	PMID:10431838
Cellular Component	GO:0070062	extracellular exosome	PACSIN2	HDA		Human	PMID:19056867
Cellular Component	GO:0019898	extrinsic component of membrane	Pacsin2	IDA		Mouse	MGI:MGI:4440389|PMID:20188097
Cellular Component	GO:0005925	focal adhesion	PACSIN2	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Pacsin2	IDA		Mouse	PMID:23918399
Cellular Component	GO:0098978	glutamatergic synapse	Pacsin2	IMP		Mouse	PMID:23918399
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PACSIN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	PACSIN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PACSIN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0055038	recycling endosome membrane	PACSIN2	IDA		Human	PMID:23596323
Biological Process	GO:0070836	caveola assembly	PACSIN2	IMP		Human	PMID:21610094
Biological Process	GO:0072584	caveolin-mediated endocytosis	PACSIN2	IMP		Human	PMID:21610094
Biological Process	GO:0048858	cell projection morphogenesis	Pacsin2	IMP		Mouse	MGI:MGI:4440389|PMID:20188097
Biological Process	GO:0060271	cilium assembly	pacsin2	IGI	ZFIN:ZDB-GENE-050913-35	Zfish	PMID:30683896
Biological Process	GO:0060271	cilium assembly	pacsin2	IMP	ZFIN:ZDB-CRISPR-190703-4	Zfish	PMID:30683896
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Pacsin2	IDA		Mouse	PMID:23918399
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Pacsin2	IMP		Mouse	PMID:23918399
Biological Process	GO:0045806	negative regulation of endocytosis	Pacsin2	IDA		Mouse	PMID:11082044
Biological Process	GO:0097320	plasma membrane tubulation	PACSIN2	IDA		Human	PMID:23596323
Biological Process	GO:0097320	plasma membrane tubulation	Pacsin2	IMP		Mouse	MGI:MGI:4440389|PMID:20188097
Biological Process	GO:0036010	protein localization to endosome	PACSIN2	IMP		Human	PMID:23596323
Biological Process	GO:0030100	regulation of endocytosis	pacsin2	IMP	ZFIN:ZDB-MRPHLNO-230202-3	Zfish	PMID:35616009
Biological Process	GO:0030100	regulation of endocytosis	pacsin2	IMP	ZFIN:ZDB-GENO-230306-2	Zfish	PMID:35616009
Biological Process	GO:0030100	regulation of endocytosis	pacsin2	IMP	ZFIN:ZDB-MRPHLNO-230202-2	Zfish	PMID:35616009

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern