Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PANX1
  • Mouse genes Panx1
  • Rat genes Panx1
  • Zfish genes panx1a,panx1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Panx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Panx1	IPI	PR:P60710	Mouse	PMID:20086016
Molecular Function	GO:0051015	actin filament binding	Panx1	IDA		Mouse	PMID:20086016
Molecular Function	GO:0005262	calcium channel activity	PANX1	IMP		Human	PMID:16908669
Molecular Function	GO:0015267	channel activity	panx1a	IDA		Zfish	PMID:24194896
Molecular Function	GO:0015267	channel activity	panx1b	IDA		Zfish	PMID:24194896
Molecular Function	GO:0005243	gap junction channel activity	Panx1	IMP		Rat	PMID:14597722|RGD:1299639
Molecular Function	GO:0055077	gap junction hemi-channel activity	panx1a	IDA		Zfish	PMID:19701745
Molecular Function	GO:0055077	gap junction hemi-channel activity	panx1a	IDA		Zfish	PMID:19409451
Molecular Function	GO:0022840	leak channel activity	PANX1	IMP		Human	PMID:16908669
Molecular Function	GO:0002020	protease binding	Panx1	IPI	RGD:2274	Rat	PMID:19416975|RGD:5491011
Molecular Function	GO:0002020	protease binding	Panx1	IPI	RGD:621757	Rat	PMID:19416975|RGD:5491011
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:O95183	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:P01375	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:P02652	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:P37268	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:P41181	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:Q14508	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:Q8NBD8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:Q92843	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:Q96IV6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:Q9BQE5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:Q9BXR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PANX1	IPI	UniProtKB:Q9NVC3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Panx1	IPI	UniProtKB:P97382	Mouse	MGI:MGI:4436986|PMID:19780818
Molecular Function	GO:0005515	protein binding	Panx1	IPI	RGD:1310963	Rat	PMID:19416975|RGD:5491011
Molecular Function	GO:0005515	protein binding	Panx1	IPI	RGD:620692	Rat	PMID:19416975|RGD:5491011
Molecular Function	GO:0044877	protein-containing complex binding	Panx1	IMP		Rat	PMID:14597722|RGD:1299639
Molecular Function	GO:0097110	scaffold protein binding	Panx1	IPI	RGD:628637	Rat	PMID:19416975|RGD:5491011
Molecular Function	GO:0005102	signaling receptor binding	PANX1	IPI	UniProtKB:Q64663	Human	PMID:17036048
Molecular Function	GO:0005198	structural molecule activity	Panx1	IDA		Rat	PMID:17715132|RGD:15090844
Molecular Function	GO:0044325	transmembrane transporter binding	Panx1	IPI	RGD:3241	Rat	PMID:19416975|RGD:5491011
Molecular Function	GO:0022832	voltage-gated channel activity	panx1a	IDA		Zfish	PMID:19409451
Molecular Function	GO:0022832	voltage-gated channel activity	panx1a	IDA		Zfish	PMID:19701745
Molecular Function	GO:0022832	voltage-gated channel activity	panx1b	IDA		Zfish	PMID:24194896
Molecular Function	GO:0022829	wide pore channel activity	panx1a	IDA		Zfish	PMID:22922822
Molecular Function	GO:0022829	wide pore channel activity	panx1b	IDA		Zfish	PMID:22922822
Cellular Component	GO:0032059	bleb	PANX1	IDA		Human	PMID:17036048
Cellular Component	GO:0031410	cytoplasmic vesicle	panx1b	IDA		Zfish	PMID:22922822
Cellular Component	GO:0005783	endoplasmic reticulum	PANX1	IDA		Human	PMID:16908669
Cellular Component	GO:0016020	membrane	PANX1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	panx1a	IDA		Zfish	PMID:19701745
Cellular Component	GO:0048471	perinuclear region of cytoplasm	panx1b	IDA		Zfish	PMID:24194896
Cellular Component	GO:0005886	plasma membrane	PANX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PANX1	IDA		Human	PMID:17036048
Cellular Component	GO:0005886	plasma membrane	Panx1	IDA		Mouse	PMID:20086016
Cellular Component	GO:0005886	plasma membrane	Panx1	IDA		Rat	PMID:17715132|RGD:15090844
Cellular Component	GO:0005886	plasma membrane	panx1a	IDA		Zfish	PMID:32533080
Cellular Component	GO:0005886	plasma membrane	panx1a	IDA		Zfish	PMID:24194896
Cellular Component	GO:0005886	plasma membrane	panx1a	IDA		Zfish	PMID:22922822
Cellular Component	GO:0005886	plasma membrane	panx1b	IDA		Zfish	PMID:22922822
Cellular Component	GO:0005886	plasma membrane	panx1b	IDA		Zfish	PMID:24194896
Cellular Component	GO:0032991	protein-containing complex	Panx1	IDA		Rat	PMID:19416975|RGD:5491011
Cellular Component	GO:0032991	protein-containing complex	Panx1	IDA		Rat	PMID:17715132|RGD:15090844
Cellular Component	GO:0032587	ruffle membrane	panx1a	IDA		Zfish	PMID:22922822
Biological Process	GO:0006816	calcium ion transport	PANX1	IMP		Human	PMID:16908669
Biological Process	GO:0007267	cell-cell signaling	Panx1	IMP		Rat	PMID:14597722|RGD:1299639
Biological Process	GO:0050908	detection of light stimulus involved in visual perception	panx1b	IMP	ZFIN:ZDB-GENO-221005-1	Zfish	PMID:34769181
Biological Process	GO:0007212	dopamine receptor signaling pathway	panx1a	IMP	ZFIN:ZDB-GENO-210415-7	Zfish	PMID:32533080
Biological Process	GO:0032610	interleukin-1 alpha production	Panx1	IMP		Mouse	PMID:18490713
Biological Process	GO:0032611	interleukin-1 beta production	Panx1	IMP		Mouse	PMID:18490713
Biological Process	GO:0010934	macrophage cytokine production	Panx1	IMP		Mouse	PMID:18490713
Biological Process	GO:0006812	monoatomic cation transport	PANX1	IDA		Human	PMID:17036048
Biological Process	GO:0032730	positive regulation of interleukin-1 alpha production	Panx1	IMP		Mouse	PMID:18490713
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	PANX1	IDA		Human	PMID:17036048
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Panx1	IMP		Mouse	PMID:18490713
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Panx1	IMP		Mouse	PMID:18490713
Biological Process	GO:0033198	response to ATP	Panx1	IMP		Mouse	PMID:18490713
Biological Process	GO:0002931	response to ischemia	Panx1	IGI	MGI:MGI:1890615	Mouse	PMID:22147915
Biological Process	GO:0036269	swimming behavior	panx1b	IMP	ZFIN:ZDB-GENO-221005-1	Zfish	PMID:34769181
Biological Process	GO:0055085	transmembrane transport	panx1a	IDA		Zfish	PMID:24194896|ZFIN:ZDB-PUB-131203-30
Biological Process	GO:0007601	visual perception	panx1a	IMP	ZFIN:ZDB-GENO-210415-7	Zfish	PMID:32533080

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern