Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PARP2
  • Mouse genes Parp2
  • Rat genes Parp2
  • Zfish genes parp2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Parp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	PARP2	IDA		Human	PMID:32939087
Molecular Function	GO:0003684	damaged DNA binding	PARP2	IDA		Human	PMID:34108479
Molecular Function	GO:0140294	NAD DNA ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:27471034
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:30104678
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:32028527
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:32939087
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:34732825
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:34795260
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	Parp2	IDA		Mouse	PMID:12065591
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	Parp2	IDA		Mouse	PMID:10364231
Molecular Function	GO:0140806	NAD+- protein-aspartate ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:25043379
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:25043379
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:28190768
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:32028527
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:32939087
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:34732825
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:34795260
Molecular Function	GO:0140807	NAD+-protein-glutamate ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:25043379
Molecular Function	GO:0140805	NAD+-protein-serine ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:28190768
Molecular Function	GO:0140805	NAD+-protein-serine ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:32028527
Molecular Function	GO:0140805	NAD+-protein-serine ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:32939087
Molecular Function	GO:0140805	NAD+-protein-serine ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:34108479
Molecular Function	GO:0140805	NAD+-protein-serine ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:34732825
Molecular Function	GO:0140805	NAD+-protein-serine ADP-ribosyltransferase activity	PARP2	IDA		Human	PMID:34795260
Molecular Function	GO:0031491	nucleosome binding	PARP2	IDA		Human	PMID:32939087
Molecular Function	GO:0072572	poly-ADP-D-ribose binding	PARP2	IDA		Human	PMID:30104678
Molecular Function	GO:0160004	poly-ADP-D-ribose modification-dependent protein binding	PARP2	IDA		Human	PMID:30104678
Molecular Function	GO:0005515	protein binding	PARP2	IPI	UniProtKB:Q00688	Human	PMID:21812934
Molecular Function	GO:0005515	protein binding	PARP2	IPI	UniProtKB:Q99469	Human	PMID:21812934
Molecular Function	GO:0005515	protein binding	PARP2	IPI	UniProtKB:Q9NWY4	Human	PMID:27067600
Molecular Function	GO:0005515	protein binding	PARP2	IPI	UniProtKB:Q9NWY4	Human	PMID:28190768
Molecular Function	GO:0005515	protein binding	PARP2	IPI	UniProtKB:Q9NWY4	Human	PMID:32939087
Molecular Function	GO:0005515	protein binding	Parp2	IPI	UniProtKB:P06748	Mouse	PMID:15615785
Molecular Function	GO:0005515	protein binding	Parp2	IPI	UniProtKB:P06746	Mouse	PMID:11948190
Molecular Function	GO:0005515	protein binding	Parp2	IPI	UniProtKB:P09874	Mouse	PMID:11948190
Molecular Function	GO:0005515	protein binding	Parp2	IPI	UniProtKB:P49916	Mouse	PMID:11948190
Molecular Function	GO:0005515	protein binding	Parp2	IPI	UniProtKB:P18887	Mouse	PMID:11948190
Cellular Component	GO:0005730	nucleolus	PARP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	PARP2	IDA		Human	PMID:15615785
Cellular Component	GO:0005730	nucleolus	Parp2	IDA		Mouse	PMID:15615785
Cellular Component	GO:0005654	nucleoplasm	PARP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	PARP2	IDA		Human	PMID:15615785
Cellular Component	GO:0005654	nucleoplasm	Parp2	IDA		Mouse	PMID:15615785
Cellular Component	GO:0005634	nucleus	PARP2	IDA		Human	PMID:26704974
Cellular Component	GO:0005634	nucleus	Parp2	IDA		Mouse	PMID:12065591
Cellular Component	GO:0090734	site of DNA damage	PARP2	IDA		Human	PMID:30104678
Cellular Component	GO:0090734	site of DNA damage	PARP2	IDA		Human	PMID:34108479
Cellular Component	GO:0090734	site of DNA damage	PARP2	IDA		Human	PMID:26704974
Cellular Component	GO:0090734	site of DNA damage	PARP2	IDA		Human	PMID:32939087
Biological Process	GO:0006284	base-excision repair	Parp2	IMP		Mouse	PMID:11948190
Biological Process	GO:0046697	decidualization	Parp2	IMP		Mouse	MGI:MGI:6771550|PMID:34580230
Biological Process	GO:0030592	DNA ADP-ribosylation	PARP2	IDA		Human	PMID:27471034
Biological Process	GO:0006974	DNA damage response	PARP2	IDA		Human	PMID:34108479
Biological Process	GO:0006281	DNA repair	PARP2	IDA		Human	PMID:30104678
Biological Process	GO:0006281	DNA repair	PARP2	IDA		Human	PMID:34108479
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling	PARP2	IDA		Human	PMID:32939087
Biological Process	GO:0006302	double-strand break repair	PARP2	IDA		Human	PMID:32939087
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Parp2	IDA		Mouse	PMID:12065591
Biological Process	GO:1901215	negative regulation of neuron death	Parp2	IMP		Rat	PMID:19422384|RGD:13514045
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	Parp2	IMP		Rat	PMID:23261455|RGD:13514044
Biological Process	GO:0070213	protein auto-ADP-ribosylation	PARP2	IDA		Human	PMID:32939087
Biological Process	GO:0070213	protein auto-ADP-ribosylation	PARP2	IDA		Human	PMID:34108479
Biological Process	GO:0070212	protein poly-ADP-ribosylation	PARP2	IDA		Human	PMID:25043379
Biological Process	GO:0070212	protein poly-ADP-ribosylation	PARP2	IDA		Human	PMID:32939087

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern