Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PAX4
  • Mouse genes Pax4
  • Rat genes Pax4
  • Zfish genes pax4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pax4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Pax4	IDA		Mouse	PMID:10567552
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Pax4	IDA		Mouse	MGI:MGI:3579957|PMID:15930104
Molecular Function	GO:0003690	double-stranded DNA binding	Pax4	IDA		Rat	PMID:10601637|RGD:729527
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pax4	IDA		Mouse	MGI:MGI:3579957|PMID:15930104
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PAX4	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Pax4	IDA		Rat	PMID:10601637|RGD:729527
Biological Process	GO:0007623	circadian rhythm	Pax4	IEP		Rat	PMID:19012751|RGD:2311636
Biological Process	GO:0031018	endocrine pancreas development	pax4	IMP	ZFIN:ZDB-MRPHLNO-160621-49	Zfish	PMID:26963759
Biological Process	GO:0042593	glucose homeostasis	pax4	IMP	ZFIN:ZDB-MRPHLNO-160621-49	Zfish	PMID:26963759
Biological Process	GO:0043066	negative regulation of apoptotic process	Pax4	IMP		Rat	PMID:17260022|RGD:2311638
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Pax4	IDA		Rat	PMID:10601637|RGD:729527
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Pax4	IDA		Mouse	MGI:MGI:3579957|PMID:15930104
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Pax4	IDA		Mouse	PMID:10567552
Biological Process	GO:1990798	pancreas regeneration	pax4	IMP	ZFIN:ZDB-MRPHLNO-160621-49	Zfish	PMID:26963759
Biological Process	GO:0030858	positive regulation of epithelial cell differentiation	Pax4	IMP	MGI:MGI:2182122	Mouse	PMID:14729487
Biological Process	GO:0045595	regulation of cell differentiation	Pax4	IMP	MGI:MGI:2182122	Mouse	PMID:14970313
Biological Process	GO:0051591	response to cAMP	Pax4	IEP		Rat	PMID:18818287|RGD:2311637
Biological Process	GO:0009410	response to xenobiotic stimulus	Pax4	IEP		Rat	PMID:18818287|RGD:2311637
Biological Process	GO:0060041	retina development in camera-type eye	Pax4	IEP		Rat	PMID:19012751|RGD:2311636
Biological Process	GO:0003309	type B pancreatic cell differentiation	Pax4	IMP	MGI:MGI:2182122	Mouse	PMID:14729487

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern