Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pax8

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PAX8
- Mouse genes Pax8
- Rat genes Pax8
- Zfish genes pax8
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pax8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	PAX8	IDA		Human	PMID:15961562
Molecular Function	GO:0003677	DNA binding	PAX8	IDA		Human	PMID:8861958
Molecular Function	GO:0003677	DNA binding	PAX8	IMP		Human	PMID:9590296
Molecular Function	GO:0003677	DNA binding	Pax8	IDA		Rat	PMID:15888455\|RGD:1600302
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Pax8	IDA		Rat	PMID:12237116\|RGD:727430
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Pax8	IDA		Rat	PMID:1508216\|RGD:8661624
Molecular Function	GO:0003700	DNA-binding transcription factor activity	PAX8	IDA		Human	PMID:9388203
Molecular Function	GO:0003700	DNA-binding transcription factor activity	PAX8	IDA		Human	PMID:9590296
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:Q9GZV5	Human	PMID:19010321
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:P19338	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:Q9NRX5	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:O75177-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:O75603	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:P31273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:P31274	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:Q00526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:Q17RB8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:Q8TEW6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAX8	IPI	UniProtKB:Q9UBE0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pax8	IPI	UniProtKB:P23441	Mouse	MGI:MGI:3693390\|PMID:12441357
Molecular Function	GO:0005515	protein binding	Pax8	IPI	UniProtKB:P23441	Rat	PMID:12441357\|RGD:8554582
Molecular Function	GO:0005515	protein binding	Pax8	IPI	UniProtKB:Q8R478	Rat	PMID:14531730\|RGD:8554093
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	PAX8	IDA		Human	PMID:9388203
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pax8	IDA		Rat	PMID:1508216\|RGD:8661624
Molecular Function	GO:0043565	sequence-specific DNA binding	Pax8	IDA		Rat	PMID:11145590\|RGD:628521
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PAX8	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	PAX8	IDA		Human	PMID:15356023
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Pax8	IDA		Mouse	MGI:MGI:3697544\|PMID:17047028
Cellular Component	GO:0005654	nucleoplasm	PAX8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	Pax8	IDA		Rat	PMID:12441357\|RGD:8554582
Cellular Component	GO:0005634	nucleus	PAX8	IDA		Human	PMID:15961562
Cellular Component	GO:0005634	nucleus	PAX8	IDA		Human	PMID:21317881
Cellular Component	GO:0005634	nucleus	PAX8	IDA		Human	PMID:9388203
Cellular Component	GO:0005634	nucleus	Pax8	IDA		Mouse	PMID:19010321
Cellular Component	GO:0005634	nucleus	Pax8	IDA		Rat	PMID:11145590\|RGD:628521
Biological Process	GO:0034672	anterior/posterior pattern specification involved in pronephros development	pax8	IGI	ZFIN:ZDB-GENO-150720-1,ZFIN:ZDB-MRPHLNO-090121-3	Zfish	PMID:23160512
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	PAX8	IEP		Human	PMID:1337742
Biological Process	GO:0071371	cellular response to gonadotropin stimulus	PAX8	IDA		Human	PMID:15961562
Biological Process	GO:0007417	central nervous system development	PAX8	IEP		Human	PMID:15494458
Biological Process	GO:0007417	central nervous system development	Pax8	IEP		Mouse	MGI:MGI:48612\|PMID:1723950
Biological Process	GO:0006351	DNA-templated transcription	PAX8	IDA		Human	PMID:9590296
Biological Process	GO:0030855	epithelial cell differentiation	Pax8	IMP	MGI:MGI:2156985	Mouse	PMID:9590297
Biological Process	GO:0042472	inner ear morphogenesis	Pax8	IGI	UniProtKB:P32114	Mouse	MGI:MGI:4822275\|PMID:20727173
Biological Process	GO:0001822	kidney development	PAX8	IEP		Human	PMID:15494458
Biological Process	GO:0072073	kidney epithelium development	Pax8	IEP		Mouse	MGI:MGI:48612\|PMID:1723950
Biological Process	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	PAX8	IEP		Human	PMID:8861958
Biological Process	GO:0072164	mesonephric tubule development	Pax8	IEP		Mouse	MGI:MGI:48612\|PMID:1723950
Biological Process	GO:0001823	mesonephros development	Pax8	IEP		Mouse	MGI:MGI:48612\|PMID:1723950
Biological Process	GO:0001823	mesonephros development	Pax8	IMP		Mouse	MGI:MGI:2445273\|PMID:12435636
Biological Process	GO:0072278	metanephric comma-shaped body morphogenesis	PAX8	IEP		Human	PMID:1337742
Biological Process	GO:0072221	metanephric distal convoluted tubule development	Pax8	IMP		Mouse	MGI:MGI:3704067\|PMID:17314325
Biological Process	GO:0072207	metanephric epithelium development	PAX8	IEP		Human	PMID:7856737
Biological Process	GO:0072289	metanephric nephron tubule formation	Pax8	IMP		Mouse	MGI:MGI:3704067\|PMID:17314325
Biological Process	GO:0072284	metanephric S-shaped body morphogenesis	PAX8	IEP		Human	PMID:1337742
Biological Process	GO:0001656	metanephros development	Pax8	IEP		Mouse	MGI:MGI:48612\|PMID:1723950
Biological Process	GO:0001656	metanephros development	Pax8	IGI	MGI:MGI:97486	Mouse	PMID:12435636
Biological Process	GO:1900215	negative regulation of apoptotic process involved in metanephric collecting duct development	Pax8	IMP		Mouse	MGI:MGI:3704067\|PMID:17314325
Biological Process	GO:1900218	negative regulation of apoptotic process involved in metanephric nephron tubule development	Pax8	IMP		Mouse	MGI:MGI:3704067\|PMID:17314325
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Pax8	IMP		Mouse	MGI:MGI:5908333\|PMID:22453009
Biological Process	GO:0072305	negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	Pax8	IMP		Mouse	MGI:MGI:3704067\|PMID:17314325
Biological Process	GO:1900212	negative regulation of mesenchymal cell apoptotic process involved in metanephros development	Pax8	IMP		Mouse	MGI:MGI:3704067\|PMID:17314325
Biological Process	GO:0043049	otic placode formation	pax8	IGI	ZFIN:ZDB-MRPHLNO-050208-1,ZFIN:ZDB-MRPHLNO-050208-2,ZFIN:ZDB-MRPHLNO-100527-3	Zfish	PMID:21215261
Biological Process	GO:0043049	otic placode formation	pax8	IGI	ZFIN:ZDB-MRPHLNO-041109-2,ZFIN:ZDB-MRPHLNO-041109-4,ZFIN:ZDB-MRPHLNO-050208-1,ZFIN:ZDB-MRPHLNO-050208-2	Zfish	PMID:15604103
Biological Process	GO:0043049	otic placode formation	pax8	IGI	ZFIN:ZDB-MRPHLNO-050208-1,ZFIN:ZDB-MRPHLNO-050208-13,ZFIN:ZDB-MRPHLNO-050208-2	Zfish	PMID:15604103
Biological Process	GO:0043049	otic placode formation	pax8	IGI	ZFIN:ZDB-GENO-980202-981	Zfish	PMID:15459102
Biological Process	GO:0043049	otic placode formation	pax8	IGI	ZFIN:ZDB-GENO-980202-822,ZFIN:ZDB-MRPHLNO-050208-1,ZFIN:ZDB-MRPHLNO-050208-2	Zfish	PMID:15604103
Biological Process	GO:0043049	otic placode formation	pax8	IMP	ZFIN:ZDB-MRPHLNO-050208-1,ZFIN:ZDB-MRPHLNO-050208-2	Zfish	PMID:15604103
Biological Process	GO:0043049	otic placode formation	pax8	IMP	ZFIN:ZDB-MRPHLNO-050208-1,ZFIN:ZDB-MRPHLNO-050208-2	Zfish	PMID:21215261
Biological Process	GO:0071599	otic vesicle development	PAX8	IEP		Human	PMID:15494458
Biological Process	GO:0007422	peripheral nervous system development	pax8	IGI	ZFIN:ZDB-MRPHLNO-050208-1,ZFIN:ZDB-MRPHLNO-050208-2,ZFIN:ZDB-MRPHLNO-100527-3	Zfish	PMID:21215261
Biological Process	GO:0007422	peripheral nervous system development	pax8	IGI	ZFIN:ZDB-GENO-980202-981,ZFIN:ZDB-MRPHLNO-050208-1,ZFIN:ZDB-MRPHLNO-050208-2,ZFIN:ZDB-MRPHLNO-050209-2	Zfish	PMID:21215261
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Pax8	IMP		Mouse	MGI:MGI:3704067\|PMID:17314325
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PAX8	IDA		Human	PMID:15356023
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PAX8	IDA		Human	PMID:15961562
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PAX8	IDA		Human	PMID:9388203
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pax8	IMP		Mouse	MGI:MGI:3704067\|PMID:17314325
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pax8	IDA		Mouse	MGI:MGI:3697544\|PMID:17047028
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pax8	IDA		Mouse	MGI:MGI:78758\|PMID:8413205
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pax8	IDA		Mouse	MGI:MGI:3693390\|PMID:12441357
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pax8	IMP		Mouse	MGI:MGI:3691903\|PMID:12586753
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pax8	IGI	UniProtKB:P32114	Mouse	MGI:MGI:3611949\|PMID:16319112
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pax8	IMP		Mouse	MGI:MGI:2445273\|PMID:12435636
Biological Process	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	Pax8	IMP		Mouse	MGI:MGI:2445273\|PMID:12435636
Biological Process	GO:2000594	positive regulation of metanephric DCT cell differentiation	Pax8	IMP		Mouse	MGI:MGI:3704067\|PMID:17314325
Biological Process	GO:2000611	positive regulation of thyroid hormone generation	PAX8	IMP		Human	PMID:15356023
Biological Process	GO:2000611	positive regulation of thyroid hormone generation	Pax8	IMP		Mouse	MGI:MGI:3691903\|PMID:12586753
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PAX8	IDA		Human	PMID:9388203
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pax8	IDA		Rat	PMID:9214635\|RGD:632682
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pax8	IDA		Rat	PMID:12237116\|RGD:727430
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pax8	IDA		Rat	PMID:1508216\|RGD:8661624
Biological Process	GO:0039003	pronephric field specification	Pax8	IEP		Mouse	MGI:MGI:2445273\|PMID:12435636
Biological Process	GO:0048793	pronephros development	Pax8	IMP		Mouse	MGI:MGI:2445273\|PMID:12435636
Biological Process	GO:0042981	regulation of apoptotic process	Pax8	IMP		Mouse	MGI:MGI:2445273\|PMID:12435636
Biological Process	GO:0006355	regulation of DNA-templated transcription	Pax8	IMP		Rat	PMID:11145590\|RGD:628521
Biological Process	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	Pax8	IMP		Mouse	MGI:MGI:3704067\|PMID:17314325
Biological Process	GO:2000612	regulation of thyroid-stimulating hormone secretion	PAX8	IMP		Human	PMID:15356023
Biological Process	GO:0072050	S-shaped body morphogenesis	Pax8	IEP		Mouse	MGI:MGI:48612\|PMID:1723950
Biological Process	GO:0006790	sulfur compound metabolic process	Pax8	IEP		Rat	PMID:12237116\|RGD:727430
Biological Process	GO:0030878	thyroid gland development	PAX8	IEP		Human	PMID:1337742
Biological Process	GO:0030878	thyroid gland development	PAX8	IEP		Human	PMID:15494458
Biological Process	GO:0030878	thyroid gland development	PAX8	IMP		Human	PMID:9590296
Biological Process	GO:0030878	thyroid gland development	Pax8	IEP		Mouse	MGI:MGI:48612\|PMID:1723950
Biological Process	GO:0030878	thyroid gland development	Pax8	IMP	MGI:MGI:2156985	Mouse	PMID:9590297
Biological Process	GO:0030878	thyroid gland development	Pax8	IGI	MGI:MGI:98742	Mouse	PMID:11773436
Biological Process	GO:0001655	urogenital system development	Pax8	IGI	UniProtKB:P32114	Mouse	MGI:MGI:2445273\|PMID:12435636
Biological Process	GO:0003281	ventricular septum development	Pax8	IMP		Mouse	MGI:MGI:5908333\|PMID:22453009

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.