Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PBX1
  • Mouse genes Pbx1
  • Rat genes Pbx1
  • Zfish genes pbx1a,pbx1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pbx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	PBX1	IDA		Human	PMID:10052460
Molecular Function	GO:0003677	DNA binding	PBX1	IDA		Human	PMID:12412021
Molecular Function	GO:0003677	DNA binding	Pbx1	IDA		Mouse	PMID:9315626
Molecular Function	GO:0003677	DNA binding	Pbx1	IDA		Mouse	PMID:9405651
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Pbx1	IDA		Mouse	MGI:MGI:5574299|PMID:19799567
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Pbx1	IDA		Mouse	PMID:22560297
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Pbx1	IDA		Mouse	MGI:MGI:6460593|PMID:32190943
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Pbx1	IPI	UniProtKB:Q60707	Mouse	MGI:MGI:6710296|PMID:33795231
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:P14653	Human	PMID:10052460
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:Q12948	Human	PMID:15684392
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:O00470	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:P55347	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:O00470	Human	PMID:20541704
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:O14770-4	Human	PMID:20553494
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:Q12948	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:P55347	Human	PMID:25856340
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:Q10571	Human	PMID:31839203
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:O14770-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:P09067	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:P31273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:Q00444	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:Q13526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:Q5JVL4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:Q5PSV4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:Q86YD7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PBX1	IPI	UniProtKB:Q96GN5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pbx1	IPI	UniProtKB:P09023|UniProtKB:P09631|UniProtKB:P09632	Mouse	MGI:MGI:5917381|PMID:22745600
Molecular Function	GO:0005515	protein binding	Pbx1	IPI	UniProtKB:P09023|UniProtKB:P09631|UniProtKB:P09632	Mouse	MGI:MGI:4455093|PMID:20211142
Molecular Function	GO:0005515	protein binding	Pbx1	IPI	PR:Q62432	Mouse	PMID:14764653
Molecular Function	GO:0005515	protein binding	Pbx1	IPI	PR:P97471	Mouse	PMID:14764653
Molecular Function	GO:0005515	protein binding	Pbx1	IPI	PR:Q60954	Mouse	PMID:9405651
Molecular Function	GO:0005515	protein binding	Pbx1	IPI	PR:Q60954	Mouse	PMID:9315626
Molecular Function	GO:0005515	protein binding	Pbx1	IPI	PR:O70477	Mouse	PMID:14764653
Molecular Function	GO:0005515	protein binding	Pbx1	IPI	PR:P43345	Mouse	PMID:15944191
Molecular Function	GO:0005515	protein binding	Pbx1	IPI	PR:O70477	Mouse	PMID:10381567
Molecular Function	GO:0005515	protein binding	Pbx1	IPI	PR:Q8BUN5	Mouse	PMID:14764653
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pbx1	IDA		Mouse	MGI:MGI:5574299|PMID:19799567
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pbx1	IDA		Mouse	PMID:14764653
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pbx1	IDA		Mouse	PMID:15944191
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	PBX1	IDA		Human	PMID:9079637
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Pbx1	IDA		Mouse	MGI:MGI:6460593|PMID:32190943
Molecular Function	GO:0043565	sequence-specific DNA binding	Pbx1	IDA		Mouse	PMID:16847320
Molecular Function	GO:0043565	sequence-specific DNA binding	Pbx1	IGI	MGI:MGI:104717	Mouse	PMID:17049510
Molecular Function	GO:0043565	sequence-specific DNA binding	Pbx1	IGI	MGI:MGI:2445415	Mouse	PMID:17049510
Molecular Function	GO:0043565	sequence-specific DNA binding	Pbx1	IGI	MGI:MGI:96182	Mouse	PMID:18787068
Molecular Function	GO:0043565	sequence-specific DNA binding	Pbx1	IGI	MGI:MGI:108564	Mouse	PMID:17049510
Molecular Function	GO:0043565	sequence-specific DNA binding	Pbx1	IGI	MGI:MGI:1201409	Mouse	PMID:17049510
Molecular Function	GO:0043565	sequence-specific DNA binding	Pbx1	IDA		Mouse	PMID:15634706
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PBX1	IDA		Human	PMID:28473536
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PBX1	IDA		Human	PMID:7791786
Molecular Function	GO:0000976	transcription cis-regulatory region binding	PBX1	IDA		Human	PMID:9191052
Molecular Function	GO:0001221	transcription coregulator binding	PBX1	IPI	UniProtKB:Q6STE5	Human	PMID:14701856
Molecular Function	GO:0001222	transcription corepressor binding	PBX1	IPI	UniProtKB:Q96AQ6	Human	PMID:10825160
Cellular Component	GO:0005737	cytoplasm	PBX1	IDA		Human	PMID:18973687
Cellular Component	GO:0005737	cytoplasm	Pbx1	IDA		Mouse	PMID:15087118
Cellular Component	GO:0005737	cytoplasm	Pbx1	IDA		Mouse	PMID:12724421
Cellular Component	GO:0005654	nucleoplasm	PBX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PBX1	IDA		Human	PMID:18973687
Cellular Component	GO:0005634	nucleus	PBX1	IDA		Human	PMID:28270404
Cellular Component	GO:0005634	nucleus	Pbx1	IDA		Mouse	MGI:MGI:6460593|PMID:32190943
Cellular Component	GO:0005634	nucleus	Pbx1	IDA		Mouse	PMID:11566859
Cellular Component	GO:0005634	nucleus	Pbx1	IDA		Mouse	PMID:15087118
Cellular Component	GO:0005634	nucleus	Pbx1	IDA		Mouse	PMID:11912494
Cellular Component	GO:0005634	nucleus	Pbx1	IDA		Mouse	PMID:9315626
Cellular Component	GO:0005634	nucleus	Pbx1	IDA		Mouse	PMID:11010815
Cellular Component	GO:0005634	nucleus	Pbx1	IDA		Mouse	PMID:12724421
Cellular Component	GO:0005634	nucleus	Pbx1	IDA		Mouse	PMID:10842069
Cellular Component	GO:0005634	nucleus	Pbx1	IDA		Mouse	PMID:15581866
Cellular Component	GO:0005634	nucleus	Pbx1	IDA		Rat	PMID:17235568|RGD:2311225
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	PBX1	IDA		Human	PMID:9079637
Cellular Component	GO:0005667	transcription regulator complex	Pbx1	IDA		Mouse	PMID:10381567
Cellular Component	GO:0005667	transcription regulator complex	Pbx1	IDA		Mouse	PMID:17049510
Cellular Component	GO:0005667	transcription regulator complex	Pbx1	IDA		Mouse	PMID:14764653
Cellular Component	GO:0005667	transcription regulator complex	Pbx1	IDA		Mouse	PMID:9405651
Biological Process	GO:0030325	adrenal gland development	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:14595835
Biological Process	GO:0009887	animal organ morphogenesis	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:11912494
Biological Process	GO:0009952	anterior/posterior pattern specification	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:11566859
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Pbx1	IDA		Mouse	PMID:12591246
Biological Process	GO:0008283	cell population proliferation	Pbx1	IMP		Mouse	PMID:22560297
Biological Process	GO:0008283	cell population proliferation	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:15944191
Biological Process	GO:0060216	definitive hemopoiesis	pbx1a	IMP	ZFIN:ZDB-MRPHLNO-110216-2	Zfish	PMID:21048033
Biological Process	GO:0035162	embryonic hemopoiesis	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:11468159
Biological Process	GO:0030326	embryonic limb morphogenesis	Pbx1	IGI	MGI:MGI:1341793	Mouse	PMID:16672333
Biological Process	GO:0048568	embryonic organ development	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:15581866
Biological Process	GO:0048706	embryonic skeletal system development	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:11566859
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	Pbx1	IMP		Mouse	PMID:22560297
Biological Process	GO:0001779	natural killer cell differentiation	Pbx1	IMP		Mouse	MGI:MGI:6460593|PMID:32190943
Biological Process	GO:0045665	negative regulation of neuron differentiation	Pbx1	IGI	MGI:MGI:104717	Mouse	PMID:18164701
Biological Process	GO:0045665	negative regulation of neuron differentiation	Pbx1	IGI	MGI:MGI:96174	Mouse	PMID:18164701
Biological Process	GO:0030223	neutrophil differentiation	pbx1a	IMP	ZFIN:ZDB-MRPHLNO-110216-2	Zfish	PMID:21048033
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	Pbx1	IMP		Mouse	PMID:22560297
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:15944191
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Pbx1	IMP		Mouse	PMID:22560297
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pbx1	IDA		Mouse	MGI:MGI:6460593|PMID:32190943
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pbx1	IDA		Mouse	MGI:MGI:5574299|PMID:19799567
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pbx1	IDA		Mouse	PMID:15944191
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pbx1	IDA		Mouse	PMID:18787068
Biological Process	GO:0009954	proximal/distal pattern formation	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:11566859
Biological Process	GO:0009954	proximal/distal pattern formation	Pbx1	IGI	MGI:MGI:1341793	Mouse	PMID:16672333
Biological Process	GO:0042127	regulation of cell population proliferation	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:11566859
Biological Process	GO:0030278	regulation of ossification	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:11566859
Biological Process	GO:0048536	spleen development	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:15944191
Biological Process	GO:0048536	spleen development	Pbx1	IGI	MGI:MGI:104737	Mouse	PMID:22560297
Biological Process	GO:0048536	spleen development	Pbx1	IGI	MGI:MGI:97350	Mouse	PMID:22560297
Biological Process	GO:0048536	spleen development	Pbx1	IGI	MGI:MGI:98769	Mouse	PMID:15944191
Biological Process	GO:0072089	stem cell proliferation	Pbx1	IMP		Mouse	PMID:22560297
Biological Process	GO:0072089	stem cell proliferation	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:15944191
Biological Process	GO:0048795	swim bladder morphogenesis	pbx1a	IMP	ZFIN:ZDB-MRPHLNO-100318-1	Zfish	PMID:20108353
Biological Process	GO:0048538	thymus development	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:15581866
Biological Process	GO:0001655	urogenital system development	Pbx1	IMP	MGI:MGI:2155612	Mouse	PMID:14595835
Biological Process	GO:0001944	vasculature development	pbx1a	IMP	ZFIN:ZDB-MRPHLNO-110216-2	Zfish	PMID:21048033

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern