Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PCK1
  • Mouse genes Pck1
  • Rat genes Pck1
  • Zfish genes pck1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pck1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031406	carboxylic acid binding	PCK1	IDA		Human	PMID:11851336
Molecular Function	GO:0031406	carboxylic acid binding	Pck1	IDA		Rat	PMID:17685635|RGD:8553769
Molecular Function	GO:0019003	GDP binding	Pck1	IDA		Rat	PMID:16125296|RGD:1601233
Molecular Function	GO:0005525	GTP binding	PCK1	IDA		Human	PMID:11851336
Molecular Function	GO:0005525	GTP binding	Pck1	IDA		Rat	PMID:17685635|RGD:8553769
Molecular Function	GO:0000287	magnesium ion binding	PCK1	IDA		Human	PMID:11851336
Molecular Function	GO:0030145	manganese ion binding	PCK1	IDA		Human	PMID:11851336
Molecular Function	GO:0030145	manganese ion binding	Pck1	IDA		Rat	PMID:17685635|RGD:8553769
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	Pck1	EXP		Rat	PMID:1383219|RGD:11059595
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	PCK1	EXP		Human	PMID:11851336
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	PCK1	IMP		Human	PMID:26971250
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	PCK1	IDA		Human	PMID:30193097
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	PCK1	IDA		Human	PMID:32322062
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck1	IMP		Mouse	MGI:MGI:6119963|PMID:29230018
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck1	IMP	MGI:MGI:2449284	Mouse	PMID:10938127
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck1	IMP	MGI:MGI:2449283	Mouse	PMID:15347677
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck1	IDA		Rat	PMID:16125296|RGD:1601233
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck1	IDA		Rat	PMID:26322521|RGD:30309937
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck1	IDA		Rat	PMID:26709450|RGD:30309918
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck1	IDA		Rat	PMID:30193097|RGD:13825433
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck1	IDA		Rat	PMID:31461616|RGD:30309906
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck1	IDA		Rat	PMID:4186849|RGD:8553288
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck1	IDA		Rat	PMID:6049928|RGD:2302971
Molecular Function	GO:0004611	phosphoenolpyruvate carboxykinase activity	Pck1	IMP	MGI:MGI:2182390	Mouse	PMID:11792850
Molecular Function	GO:0004611	phosphoenolpyruvate carboxykinase activity	Pck1	IDA		Rat	PMID:11440903|RGD:2302970
Molecular Function	GO:0004611	phosphoenolpyruvate carboxykinase activity	Pck1	IDA		Rat	PMID:11820793|RGD:625518
Molecular Function	GO:0004611	phosphoenolpyruvate carboxykinase activity	Pck1	IDA		Rat	PMID:4303362|RGD:2302850
Molecular Function	GO:0004611	phosphoenolpyruvate carboxykinase activity	Pck1	IDA		Rat	PMID:4353083|RGD:2302851
Molecular Function	GO:0106264	protein serine kinase activity (using GTP as donor)	PCK1	IDA		Human	PMID:32322062
Cellular Component	GO:0005737	cytoplasm	Pck1	IDA		Rat	PMID:4186849|RGD:8553288
Cellular Component	GO:0005829	cytosol	PCK1	IDA		Human	PMID:32322062
Cellular Component	GO:0005829	cytosol	Pck1	IDA		Mouse	PMID:19458124
Cellular Component	GO:0005783	endoplasmic reticulum	PCK1	IDA		Human	PMID:32322062
Cellular Component	GO:0070062	extracellular exosome	PCK1	HDA		Human	PMID:19056867
Biological Process	GO:0007568	aging	Pck1	IEP		Rat	PMID:24177414|RGD:10445837
Biological Process	GO:0071474	cellular hyperosmotic response	Pck1	IEP		Rat	PMID:9530152|RGD:151665787
Biological Process	GO:0071475	cellular hyperosmotic salinity response	Pck1	IEP		Rat	PMID:9530152|RGD:151665787
Biological Process	GO:0071476	cellular hypotonic response	Pck1	IEP		Rat	PMID:9530152|RGD:151665787
Biological Process	GO:0071477	cellular hypotonic salinity response	Pck1	IEP		Rat	PMID:9530152|RGD:151665787
Biological Process	GO:0071320	cellular response to cAMP	Pck1	IEP		Rat	PMID:18335579|RGD:10445832
Biological Process	GO:0071320	cellular response to cAMP	Pck1	IEP		Rat	PMID:9530152|RGD:151665787
Biological Process	GO:0071332	cellular response to fructose stimulus	Pck1	IEP		Rat	PMID:21212096|RGD:9585757
Biological Process	GO:0071377	cellular response to glucagon stimulus	Pck1	IEP		Rat	PMID:18335579|RGD:10445832
Biological Process	GO:0071333	cellular response to glucose stimulus	PCK1	IDA		Human	PMID:30193097
Biological Process	GO:0071333	cellular response to glucose stimulus	Pck1	IDA		Rat	PMID:30193097|RGD:13825433
Biological Process	GO:0071456	cellular response to hypoxia	Pck1	IEP		Rat	PMID:24177414|RGD:10445837
Biological Process	GO:0032869	cellular response to insulin stimulus	PCK1	IDA		Human	PMID:32322062
Biological Process	GO:0032869	cellular response to insulin stimulus	Pck1	IEP		Rat	PMID:21519922|RGD:10428394
Biological Process	GO:0032869	cellular response to insulin stimulus	Pck1	IEP		Rat	PMID:9530152|RGD:151665787
Biological Process	GO:0071347	cellular response to interleukin-1	Pck1	IEP		Rat	PMID:18335579|RGD:10445832
Biological Process	GO:1904628	cellular response to phorbol 13-acetate 12-myristate	Pck1	IEP		Rat	PMID:9530152|RGD:151665787
Biological Process	GO:0051365	cellular response to potassium ion starvation	Pck1	IDA		Mouse	PMID:19458124
Biological Process	GO:0097403	cellular response to raffinose	Pck1	IEP		Rat	PMID:9530152|RGD:151665787
Biological Process	GO:0071300	cellular response to retinoic acid	Pck1	IEP		Rat	PMID:21519922|RGD:10428394
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Pck1	IEP		Rat	PMID:18335579|RGD:10445832
Biological Process	GO:0006094	gluconeogenesis	PCK1	IMP		Human	PMID:26971250
Biological Process	GO:0006094	gluconeogenesis	PCK1	IDA		Human	PMID:30193097
Biological Process	GO:0006094	gluconeogenesis	Pck1	IMP		Mouse	MGI:MGI:6119963|PMID:29230018
Biological Process	GO:0006094	gluconeogenesis	Pck1	IMP	MGI:MGI:2449284	Mouse	PMID:10938127
Biological Process	GO:0006094	gluconeogenesis	Pck1	IDA		Mouse	PMID:19643083
Biological Process	GO:0006094	gluconeogenesis	Pck1	IMP	MGI:MGI:2449283	Mouse	PMID:15347677
Biological Process	GO:0006094	gluconeogenesis	Pck1	IMP		Mouse	PMID:34156032
Biological Process	GO:0006094	gluconeogenesis	Pck1	IDA		Mouse	PMID:11916968
Biological Process	GO:0006094	gluconeogenesis	Pck1	IDA		Rat	PMID:11440903|RGD:2302970
Biological Process	GO:0006094	gluconeogenesis	Pck1	IDA		Rat	PMID:4186849|RGD:8553288
Biological Process	GO:0006094	gluconeogenesis	Pck1	IDA		Rat	PMID:4303362|RGD:2302850
Biological Process	GO:0006094	gluconeogenesis	Pck1	IDA		Rat	PMID:4353083|RGD:2302851
Biological Process	GO:0006094	gluconeogenesis	Pck1	IDA		Rat	PMID:6049928|RGD:2302971
Biological Process	GO:0042593	glucose homeostasis	Pck1	IDA		Rat	PMID:4186849|RGD:8553288
Biological Process	GO:0006006	glucose metabolic process	PCK1	IMP		Human	PMID:14764811
Biological Process	GO:0006006	glucose metabolic process	Pck1	IMP		Rat	PMID:18055057|RGD:8554791
Biological Process	GO:0046327	glycerol biosynthetic process from pyruvate	Pck1	IMP	MGI:MGI:2182390	Mouse	PMID:11792850
Biological Process	GO:0046327	glycerol biosynthetic process from pyruvate	Pck1	IDA		Rat	PMID:4186849|RGD:8553288
Biological Process	GO:0006629	lipid metabolic process	Pck1	IMP	MGI:MGI:2182390	Mouse	PMID:11792850
Biological Process	GO:0050801	monoatomic ion homeostasis	pck1	IMP	ZFIN:ZDB-MRPHLNO-151012-1	Zfish	PMID:25999794
Biological Process	GO:0006107	oxaloacetate metabolic process	PCK1	IDA		Human	PMID:30193097
Biological Process	GO:0006107	oxaloacetate metabolic process	Pck1	IMP		Mouse	MGI:MGI:6119963|PMID:29230018
Biological Process	GO:0006107	oxaloacetate metabolic process	Pck1	IDA		Rat	PMID:16125296|RGD:1601233
Biological Process	GO:0006107	oxaloacetate metabolic process	Pck1	IDA		Rat	PMID:26322521|RGD:30309937
Biological Process	GO:0006107	oxaloacetate metabolic process	Pck1	IDA		Rat	PMID:26709450|RGD:30309918
Biological Process	GO:0006107	oxaloacetate metabolic process	Pck1	IDA		Rat	PMID:30193097|RGD:13825433
Biological Process	GO:0006107	oxaloacetate metabolic process	Pck1	IDA		Rat	PMID:31461616|RGD:30309906
Biological Process	GO:0006107	oxaloacetate metabolic process	Pck1	IDA		Rat	PMID:4303362|RGD:2302850
Biological Process	GO:0006107	oxaloacetate metabolic process	Pck1	IDA		Rat	PMID:6049928|RGD:2302971
Biological Process	GO:0018105	peptidyl-serine phosphorylation	PCK1	IDA		Human	PMID:32322062
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	PCK1	IDA		Human	PMID:32322062
Biological Process	GO:0043382	positive regulation of memory T cell differentiation	Pck1	IMP		Mouse	MGI:MGI:6119963|PMID:29230018
Biological Process	GO:0061402	positive regulation of transcription from RNA polymerase II promoter in response to acidic pH	Pck1	IDA		Mouse	PMID:19458124
Biological Process	GO:0046890	regulation of lipid biosynthetic process	PCK1	IDA		Human	PMID:32322062
Biological Process	GO:0014823	response to activity	Pck1	IEP		Rat	PMID:16458327|RGD:2311644
Biological Process	GO:0009617	response to bacterium	Pck1	IEP		Mouse	PMID:23012479
Biological Process	GO:0009749	response to glucose	pck1	IDA		Zfish	PMID:17446233
Biological Process	GO:0032868	response to insulin	PCK1	IDA		Human	PMID:14764811
Biological Process	GO:0070741	response to interleukin-6	Pck1	IEP		Rat	PMID:17805558|RGD:10445833
Biological Process	GO:0033993	response to lipid	Pck1	IEP		Rat	PMID:21486814|RGD:10445838
Biological Process	GO:0032496	response to lipopolysaccharide	Pck1	IEP		Rat	PMID:19268478|RGD:10427879
Biological Process	GO:1901558	response to metformin	Pck1	IEP		Rat	PMID:23307605|RGD:152177519
Biological Process	GO:1904640	response to methionine	Pck1	IEP		Rat	PMID:23052097|RGD:10401915
Biological Process	GO:0031667	response to nutrient levels	Pck1	IEP		Rat	PMID:23307605|RGD:152177519
Biological Process	GO:0031667	response to nutrient levels	Pck1	IEP		Rat	PMID:25943649|RGD:152995488
Biological Process	GO:0072350	tricarboxylic acid metabolic process	PCK1	IDA		Human	PMID:30193097

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern