Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PCLO
  • Mouse genes Pclo
  • Rat genes Pclo
  • Zfish genes pcloa,pclob
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pclo

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Pclo	IDA		Rat	PMID:11285225|RGD:68715
Molecular Function	GO:0005509	calcium ion binding	Pclo	IDA		Rat	PMID:14718922|RGD:9850099
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	Pclo	IDA		Rat	PMID:11285225|RGD:68715
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	Pclo	IDA		Rat	PMID:14718922|RGD:9850099
Molecular Function	GO:0005522	profilin binding	Pclo	IDA		Mouse	PMID:10508862
Molecular Function	GO:0005515	protein binding	Pclo	IPI	PR:Q4KUS2	Mouse	PMID:19812333
Molecular Function	GO:0005515	protein binding	Pclo	IPI	PR:O88737	Mouse	PMID:19812333
Molecular Function	GO:0005515	protein binding	Pclo	IPI	PR:Q9EQZ6	Mouse	PMID:12401793
Molecular Function	GO:0005515	protein binding	Pclo	IPI	PR:Q99NE5	Mouse	PMID:19812333
Molecular Function	GO:0005515	protein binding	Pclo	IPI	PR:Q7TN73	Mouse	PMID:19812333
Molecular Function	GO:0005515	protein binding	Pclo	IPI	PR:Q9EQZ7	Mouse	PMID:12401793
Molecular Function	GO:0005515	protein binding	Pclo	IPI	UniProtKB:Q9Z272	Rat	PMID:12473661|RGD:9850090
Molecular Function	GO:0005515	protein binding	Pclo	IPI	UniProtKB:Q920M9	Rat	PMID:23403927|RGD:8554101
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	Pclo	IMP		Mouse	PMID:26793095
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	Pclo	IPI		Mouse	PMID:26793095
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	Pclo	IDA		Mouse	PMID:26793095
Molecular Function	GO:0001222	transcription corepressor binding	Pclo	IPI	UniProtKB:Q9Z2F5	Rat	PMID:25652077|RGD:11079187
Cellular Component	GO:0030424	axon	Pclo	IDA		Rat	PMID:11182086|RGD:9850132
Cellular Component	GO:0044316	cone cell pedicle	Pclo	IDA		Rat	PMID:11596050|RGD:9850129
Cellular Component	GO:0048788	cytoskeleton of presynaptic active zone	Pclo	IDA		Rat	PMID:11596050|RGD:9850129
Cellular Component	GO:0030425	dendrite	Pclo	IDA		Rat	PMID:11182086|RGD:9850132
Cellular Component	GO:0070062	extracellular exosome	PCLO	HDA		Human	PMID:18570454
Cellular Component	GO:0098978	glutamatergic synapse	Pclo	IDA		Rat	PMID:21712437|RGD:9850098
Cellular Component	GO:0005798	Golgi-associated vesicle	Pclo	IDA		Rat	PMID:22875941|RGD:14390063
Cellular Component	GO:0030426	growth cone	Pclo	IDA		Rat	PMID:11182086|RGD:9850132
Cellular Component	GO:0060077	inhibitory synapse	Pclo	IDA		Rat	PMID:11596050|RGD:9850129
Cellular Component	GO:0031594	neuromuscular junction	Pclo	IDA		Rat	PMID:17156365|RGD:9850148
Cellular Component	GO:0043005	neuron projection	Pclo	IDA		Rat	PMID:12473661|RGD:9850090
Cellular Component	GO:0043025	neuronal cell body	Pclo	IDA		Rat	PMID:11182086|RGD:9850132
Cellular Component	GO:0043025	neuronal cell body	Pclo	IDA		Rat	PMID:16373352|RGD:9850093
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Pclo	IDA		Rat	PMID:21712437|RGD:9850098
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Pclo	IDA		Rat	PMID:17156365|RGD:9850148
Cellular Component	GO:0014069	postsynaptic density	Pclo	IDA		Mouse	PMID:17114649
Cellular Component	GO:0048786	presynaptic active zone	Pclo	IDA		Rat	PMID:11182086|RGD:9850132
Cellular Component	GO:0048786	presynaptic active zone	Pclo	IDA		Rat	PMID:22875941|RGD:14390063
Cellular Component	GO:0098831	presynaptic active zone cytoplasmic component	Pclo	IDA		Mouse	MGI:MGI:5816444|PMID:21144999
Cellular Component	GO:0098831	presynaptic active zone cytoplasmic component	Pclo	IDA		Rat	PMID:21712437|RGD:9850098
Cellular Component	GO:0098831	presynaptic active zone cytoplasmic component	Pclo	IDA		Rat	PMID:31959215|RGD:155230771
Cellular Component	GO:0097470	ribbon synapse	Pclo	IDA		Rat	PMID:21712437|RGD:9850098
Cellular Component	GO:0044317	rod spherule	Pclo	IDA		Rat	PMID:11596050|RGD:9850129
Cellular Component	GO:0045202	synapse	Pclo	IDA		Mouse	MGI:MGI:1346191|PMID:10508862
Cellular Component	GO:0045202	synapse	Pclo	IDA		Mouse	PMID:19812333
Cellular Component	GO:0045202	synapse	Pclo	IDA		Rat	PMID:10707984|RGD:69383
Cellular Component	GO:0045202	synapse	Pclo	IDA		Rat	PMID:12473661|RGD:9850090
Cellular Component	GO:0043195	terminal bouton	Pclo	IDA		Rat	PMID:11182086|RGD:9850132
Cellular Component	GO:0005802	trans-Golgi network	Pclo	IDA		Rat	PMID:16373352|RGD:9850093
Cellular Component	GO:0030133	transport vesicle	Pclo	IDA		Rat	PMID:11182086|RGD:9850132
Biological Process	GO:0007010	cytoskeleton organization	Pclo	IDA		Mouse	PMID:10508862
Biological Process	GO:0030073	insulin secretion	Pclo	IDA		Mouse	PMID:12401793
Biological Process	GO:0098815	modulation of excitatory postsynaptic potential	Pclo	IMP		Rat	PMID:31074746|RGD:41408338
Biological Process	GO:1903423	positive regulation of synaptic vesicle recycling	Pclo	IMP		Rat	PMID:31074746|RGD:41408338
Biological Process	GO:0099526	presynapse to nucleus signaling pathway	Pclo	IMP		Mouse	MGI:MGI:5635967|PMID:25652077
Biological Process	GO:1904071	presynaptic active zone assembly	Pclo	IDA		Rat	PMID:22875941|RGD:14390063
Biological Process	GO:0035418	protein localization to synapse	Pclo	IGI	UniProtKB:O88737	Mouse	MGI:MGI:5635967|PMID:25652077
Biological Process	GO:0051036	regulation of endosome size	Pclo	IMP		Rat	PMID:31074746|RGD:41408338
Biological Process	GO:0017157	regulation of exocytosis	Pclo	IDA		Mouse	PMID:12401793
Biological Process	GO:1904666	regulation of ubiquitin protein ligase activity	Pclo	IDA		Rat	PMID:23403927|RGD:8554101
Biological Process	GO:0050808	synapse organization	Pclo	IDA		Rat	PMID:23403927|RGD:8554101
Biological Process	GO:0097091	synaptic vesicle clustering	Pclo	IMP		Mouse	PMID:20332206
Biological Process	GO:0097091	synaptic vesicle clustering	Pclo	IDA		Mouse	PMID:20332206

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern