Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PCSK2
  • Mouse genes Pcsk2
  • Rat genes Pcsk2
  • Zfish genes pcsk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pcsk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	Pcsk2	IDA		Mouse	MGI:MGI:3807770|PMID:9242664
Molecular Function	GO:0005515	protein binding	PCSK2	IPI	UniProtKB:Q96IK1-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PCSK2	IPI	UniProtKB:P05408	Human	PMID:7913882
Molecular Function	GO:0005515	protein binding	Pcsk2	IPI	UniProtKB:P27682	Rat	PMID:16286464|RGD:1580325
Molecular Function	GO:0004252	serine-type endopeptidase activity	PCSK2	IDA		Human	PMID:7626024
Molecular Function	GO:0004252	serine-type endopeptidase activity	Pcsk2	IDA		Mouse	MGI:MGI:3773775|PMID:8262946
Molecular Function	GO:0004252	serine-type endopeptidase activity	Pcsk2	IMP	MGI:MGI:1857445	Mouse	PMID:9452465
Molecular Function	GO:0004252	serine-type endopeptidase activity	Pcsk2	EXP		Rat	PMID:1429623|RGD:13506272
Molecular Function	GO:0004252	serine-type endopeptidase activity	Pcsk2	IMP		Rat	PMID:15983213|RGD:8554260
Molecular Function	GO:0004252	serine-type endopeptidase activity	Pcsk2	EXP		Rat	PMID:3283564|RGD:13506270
Cellular Component	GO:0030425	dendrite	Pcsk2	IDA		Rat	PMID:17543468|RGD:2308893
Cellular Component	GO:0005615	extracellular space	PCSK2	IDA		Human	PMID:28719828
Cellular Component	GO:0005615	extracellular space	PCSK2	IDA		Human	PMID:9020868
Cellular Component	GO:0005615	extracellular space	Pcsk2	IDA		Mouse	MGI:MGI:3793923|PMID:8397508
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PCSK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	PCSK2	IDA		Human	PMID:8034613
Cellular Component	GO:0043025	neuronal cell body	Pcsk2	IDA		Rat	PMID:17543468|RGD:2308893
Cellular Component	GO:0005654	nucleoplasm	PCSK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043204	perikaryon	Pcsk2	IDA		Rat	PMID:17543468|RGD:2308893
Cellular Component	GO:0030141	secretory granule	Pcsk2	IDA		Mouse	PMID:9452465
Cellular Component	GO:0030141	secretory granule	Pcsk2	IDA		Rat	PMID:7822759|RGD:2308908
Biological Process	GO:0034230	enkephalin processing	Pcsk2	IDA		Mouse	MGI:MGI:3773775|PMID:8262946
Biological Process	GO:0030070	insulin processing	PCSK2	IDA		Human	PMID:7626024
Biological Process	GO:0030070	insulin processing	Pcsk2	IMP	MGI:MGI:1857445	Mouse	PMID:9452465
Biological Process	GO:0034231	islet amyloid polypeptide processing	Pcsk2	IMP		Rat	PMID:15983213|RGD:8554260
Biological Process	GO:0007399	nervous system development	Pcsk2	IEP		Mouse	MGI:MGI:3696588|PMID:16893422
Biological Process	GO:0016486	peptide hormone processing	PCSK2	IDA		Human	PMID:28719828
Biological Process	GO:0016486	peptide hormone processing	Pcsk2	IDA		Mouse	MGI:MGI:3807770|PMID:9242664
Biological Process	GO:0016486	peptide hormone processing	Pcsk2	IMP	MGI:MGI:1857445	Mouse	PMID:12859669
Biological Process	GO:0016486	peptide hormone processing	Pcsk2	IMP		Rat	PMID:16497799|RGD:1601276
Biological Process	GO:0016540	protein autoprocessing	Pcsk2	IDA		Mouse	MGI:MGI:3696588|PMID:16893422
Biological Process	GO:0016485	protein processing	Pcsk2	IDA		Mouse	MGI:MGI:3807770|PMID:9242664
Biological Process	GO:0016485	protein processing	Pcsk2	IMP		Rat	PMID:16497799|RGD:1601276
Biological Process	GO:0006508	proteolysis	PCSK2	IDA		Human	PMID:7626024
Biological Process	GO:0006508	proteolysis	Pcsk2	IMP	MGI:MGI:1857445	Mouse	PMID:12859669

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern