Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pcsk9

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PCSK9
- Mouse genes Pcsk9
- Rat genes Pcsk9
- Zfish genes pcsk9
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pcsk9

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034185	apolipoprotein binding	Pcsk9	IDA		Mouse	MGI:MGI:5431159\|PMID:22580899
Molecular Function	GO:0034190	apolipoprotein receptor binding	PCSK9	IDA		Human	PMID:18039658
Molecular Function	GO:0030169	low-density lipoprotein particle binding	Pcsk9	IDA		Mouse	MGI:MGI:5431159\|PMID:22580899
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	PCSK9	IDA		Human	PMID:17080197
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	PCSK9	IPI	UniProtKB:P01130	Human	PMID:17452316
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	PCSK9	IPI	UniProtKB:P01130	Human	PMID:22848640
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	Pcsk9	IDA		Mouse	MGI:MGI:3690469\|PMID:17080197
Molecular Function	GO:0005515	protein binding	PCSK9	IPI	UniProtKB:P01130	Human	PMID:17461796
Molecular Function	GO:0005515	protein binding	PCSK9	IPI	UniProtKB:P07355	Human	PMID:18799458
Molecular Function	GO:0005515	protein binding	PCSK9	IPI	UniProtKB:P01130	Human	PMID:22081141
Molecular Function	GO:0005515	protein binding	PCSK9	IPI	UniProtKB:P37088	Human	PMID:22493497
Molecular Function	GO:0005515	protein binding	PCSK9	IPI	UniProtKB:P51168	Human	PMID:22493497
Molecular Function	GO:0005515	protein binding	PCSK9	IPI	UniProtKB:P51170	Human	PMID:22493497
Molecular Function	GO:0005515	protein binding	PCSK9	IPI	UniProtKB:P04114	Human	PMID:22580899
Molecular Function	GO:0005515	protein binding	PCSK9	IPI	UniProtKB:P07355	Human	PMID:22848640
Molecular Function	GO:0005515	protein binding	PCSK9	IPI	UniProtKB:P01130	Human	PMID:25613181
Molecular Function	GO:0005515	protein binding	PCSK9	IPI	UniProtKB:P08253	Human	PMID:25613181
Molecular Function	GO:0043621	protein self-association	PCSK9	IDA		Human	PMID:18197702
Molecular Function	GO:0003723	RNA binding	PCSK9	HDA		Human	PMID:22658674
Molecular Function	GO:0004252	serine-type endopeptidase activity	PCSK9	IDA		Human	PMID:12552133
Molecular Function	GO:0030547	signaling receptor inhibitor activity	PCSK9	IDA		Human	PMID:22848640
Molecular Function	GO:0019871	sodium channel inhibitor activity	PCSK9	IDA		Human	PMID:22493497
Molecular Function	GO:0034189	very-low-density lipoprotein particle binding	Pcsk9	IDA		Mouse	MGI:MGI:5431159\|PMID:22580899
Molecular Function	GO:0070326	very-low-density lipoprotein particle receptor binding	PCSK9	IDA		Human	PMID:18039658
Cellular Component	GO:0009986	cell surface	PCSK9	IDA		Human	PMID:17461796
Cellular Component	GO:0030134	COPII-coated ER to Golgi transport vesicle	Pcsk9	IDA		Mouse	PMID:23580231
Cellular Component	GO:0005737	cytoplasm	PCSK9	IDA		Human	PMID:22580899
Cellular Component	GO:0005769	early endosome	PCSK9	IDA		Human	PMID:17461796
Cellular Component	GO:0005783	endoplasmic reticulum	PCSK9	IDA		Human	PMID:17461796
Cellular Component	GO:0005783	endoplasmic reticulum	Pcsk9	IDA		Mouse	PMID:23580231
Cellular Component	GO:0005576	extracellular region	Pcsk9	IDA		Mouse	PMID:12552133
Cellular Component	GO:0005615	extracellular space	PCSK9	IDA		Human	PMID:12552133
Cellular Component	GO:0005615	extracellular space	PCSK9	IDA		Human	PMID:16912035
Cellular Component	GO:0005615	extracellular space	PCSK9	IDA		Human	PMID:17080197
Cellular Component	GO:0005615	extracellular space	Pcsk9	IDA		Mouse	MGI:MGI:3690469\|PMID:17080197
Cellular Component	GO:0005615	extracellular space	Pcsk9	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Pcsk9	IDA		Rat	PMID:16462892\|RGD:1582517
Cellular Component	GO:0005794	Golgi apparatus	PCSK9	IDA		Human	PMID:17461796
Cellular Component	GO:0005770	late endosome	PCSK9	IDA		Human	PMID:17461796
Cellular Component	GO:0005770	late endosome	PCSK9	IDA		Human	PMID:18039658
Cellular Component	GO:0005764	lysosome	PCSK9	IDA		Human	PMID:17461796
Cellular Component	GO:0005764	lysosome	PCSK9	IDA		Human	PMID:18039658
Cellular Component	GO:1990667	PCSK9-AnxA2 complex	PCSK9	IPI		Human	PMID:24808179
Cellular Component	GO:1990667	PCSK9-AnxA2 complex	PCSK9	IDA		Human	PMID:22848640
Cellular Component	GO:1990666	PCSK9-LDLR complex	PCSK9	IDA		Human	PMID:22848640
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PCSK9	IDA		Human	PMID:18039658
Cellular Component	GO:0005886	plasma membrane	PCSK9	IDA		Human	PMID:18799458
Cellular Component	GO:0005791	rough endoplasmic reticulum	Pcsk9	IDA		Rat	PMID:16462892\|RGD:1582517
Biological Process	GO:0032869	cellular response to insulin stimulus	Pcsk9	IDA		Mouse	MGI:MGI:3700436\|PMID:16407292
Biological Process	GO:0032869	cellular response to insulin stimulus	Pcsk9	IDA		Rat	PMID:16407292\|RGD:8553473
Biological Process	GO:0009267	cellular response to starvation	Pcsk9	IDA		Mouse	MGI:MGI:3700436\|PMID:16407292
Biological Process	GO:0009267	cellular response to starvation	Pcsk9	IDA		Rat	PMID:16407292\|RGD:8553473
Biological Process	GO:0007417	central nervous system development	pcsk9	IMP	ZFIN:ZDB-MRPHLNO-060927-8	Zfish	PMID:16893422
Biological Process	GO:0042632	cholesterol homeostasis	PCSK9	IMP		Human	PMID:17170371
Biological Process	GO:0042632	cholesterol homeostasis	Pcsk9	IEP		Rat	PMID:16462892\|RGD:1582517
Biological Process	GO:0008203	cholesterol metabolic process	Pcsk9	IDA		Mouse	PMID:17242417
Biological Process	GO:0001822	kidney development	Pcsk9	IEP		Mouse	MGI:MGI:2450048\|PMID:12552133
Biological Process	GO:0001822	kidney development	Pcsk9	IEP		Rat	PMID:12552133\|RGD:629554
Biological Process	GO:0042157	lipoprotein metabolic process	Pcsk9	IDA		Mouse	PMID:17242417
Biological Process	GO:0001889	liver development	Pcsk9	IEP		Mouse	MGI:MGI:2450048\|PMID:12552133
Biological Process	GO:0001889	liver development	Pcsk9	IEP		Rat	PMID:12552133\|RGD:629554
Biological Process	GO:0032802	low-density lipoprotein particle receptor catabolic process	PCSK9	IDA		Human	PMID:16912035
Biological Process	GO:0032802	low-density lipoprotein particle receptor catabolic process	PCSK9	IDA		Human	PMID:18197702
Biological Process	GO:0032799	low-density lipoprotein receptor particle metabolic process	Pcsk9	IDA		Mouse	PMID:17242417
Biological Process	GO:0007041	lysosomal transport	PCSK9	IDA		Human	PMID:17452316
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	PCSK9	IDA		Human	PMID:17328821
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	PCSK9	IDA		Human	PMID:22848640
Biological Process	GO:1905596	negative regulation of low-density lipoprotein particle receptor binding	PCSK9	IDA		Human	PMID:22848640
Biological Process	GO:1905598	negative regulation of low-density lipoprotein receptor activity	PCSK9	IDA		Human	PMID:22848640
Biological Process	GO:0002091	negative regulation of receptor internalization	PCSK9	IDA		Human	PMID:18799458
Biological Process	GO:0001920	negative regulation of receptor recycling	PCSK9	IDA		Human	PMID:17452316
Biological Process	GO:0001920	negative regulation of receptor recycling	PCSK9	IDA		Human	PMID:22848640
Biological Process	GO:1905601	negative regulation of receptor-mediated endocytosis involved in cholesterol transport	PCSK9	IDA		Human	PMID:22848640
Biological Process	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	PCSK9	IDA		Human	PMID:22493497
Biological Process	GO:0022008	neurogenesis	Pcsk9	IEP		Mouse	MGI:MGI:2450048\|PMID:12552133
Biological Process	GO:0022008	neurogenesis	Pcsk9	IEP		Rat	PMID:12552133\|RGD:629554
Biological Process	GO:0022008	neurogenesis	pcsk9	IMP	ZFIN:ZDB-MRPHLNO-060927-8	Zfish	PMID:16893422
Biological Process	GO:0030182	neuron differentiation	Pcsk9	IMP		Mouse	MGI:MGI:2450048\|PMID:12552133
Biological Process	GO:0030182	neuron differentiation	Pcsk9	IDA		Mouse	MGI:MGI:3696588\|PMID:16893422
Biological Process	GO:0006644	phospholipid metabolic process	Pcsk9	IDA		Mouse	PMID:17242417
Biological Process	GO:0032805	positive regulation of low-density lipoprotein particle receptor catabolic process	PCSK9	IDA		Human	PMID:22848640
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	PCSK9	IMP		Human	PMID:17051583
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Pcsk9	IDA		Rat	PMID:17051583\|RGD:1599462
Biological Process	GO:0002092	positive regulation of receptor internalization	PCSK9	IDA		Human	PMID:17328821
Biological Process	GO:0016540	protein autoprocessing	PCSK9	IDA		Human	PMID:14622975
Biological Process	GO:0016540	protein autoprocessing	Pcsk9	IDA		Rat	PMID:14622975\|RGD:1582518
Biological Process	GO:0016485	protein processing	Pcsk9	IDA		Rat	PMID:14622975\|RGD:1582518
Biological Process	GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process	Pcsk9	IMP		Mouse	PMID:15741654
Biological Process	GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process	Pcsk9	IMP	MGI:MGI:3577021	Mouse	PMID:15805190
Biological Process	GO:0043523	regulation of neuron apoptotic process	Pcsk9	IMP		Mouse	MGI:MGI:5431198\|PMID:22481440
Biological Process	GO:0010469	regulation of signaling receptor activity	PCSK9	IDA		Human	PMID:17328821
Biological Process	GO:0006641	triglyceride metabolic process	Pcsk9	IDA		Mouse	PMID:17242417

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.