Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDCD4
  • Mouse genes Pdcd4
  • Rat genes Pdcd4
  • Zfish genes pdcd4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdcd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P05386	Human	PMID:12054647
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P46777	Human	PMID:12054647
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P62277	Human	PMID:12054647
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:Q04637	Human	PMID:12054647
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P31750	Human	PMID:16357133
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P60842	Human	PMID:18296639
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P60842	Human	PMID:19204291
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P02649	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P49810	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P60842	Human	PMID:24413684
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:Q04206	Human	PMID:24413684
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P38919	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:Q14240	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P60842	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:P38919	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PDCD4	IPI	UniProtKB:Q14240-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pdcd4	IPI	UniProtKB:P60843	Mouse	MGI:MGI:3836198|PMID:19153607
Molecular Function	GO:0005515	protein binding	Pdcd4	IPI	UniProtKB:Q62448	Mouse	MGI:MGI:3687918|PMID:12482958
Molecular Function	GO:0005515	protein binding	Pdcd4	IPI	UniProtKB:P05412|UniProtKB:P45983	Mouse	MGI:MGI:3688347|PMID:15334056
Cellular Component	GO:0005737	cytoplasm	PDCD4	IMP		Human	PMID:16357133
Cellular Component	GO:0005829	cytosol	PDCD4	IDA		Human	PMID:12054647
Cellular Component	GO:0005634	nucleus	PDCD4	IMP		Human	PMID:16357133
Cellular Component	GO:0005634	nucleus	Pdcd4	IDA		Rat	PMID:23441172|RGD:10400865
Biological Process	GO:0003171	atrioventricular valve development	pdcd4b	IGI	ZFIN:ZDB-MRPHLNO-130806-1,ZFIN:ZDB-MRPHLNO-130806-4	Zfish	PMID:23578931
Biological Process	GO:0003171	atrioventricular valve development	pdcd4b	IMP	ZFIN:ZDB-MRPHLNO-131023-1	Zfish	PMID:23578931
Biological Process	GO:0030509	BMP signaling pathway	PDCD4	IDA		Human	PMID:18548003
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Pdcd4	IMP		Mouse	MGI:MGI:4438829|PMID:19946272
Biological Process	GO:0060940	epithelial to mesenchymal transition involved in cardiac fibroblast development	Pdcd4	IGI	RNAcentral:URS000039ED8D_10116	Rat	PMID:23441172|RGD:10400865
Biological Process	GO:0043066	negative regulation of apoptotic process	Pdcd4	IDA		Rat	PMID:12220511|RGD:633555
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	Pdcd4	IMP		Mouse	MGI:MGI:4438829|PMID:19946272
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	Pdcd4	IMP		Mouse	MGI:MGI:3707264|PMID:17114484
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PDCD4	IDA		Human	PMID:16357133
Biological Process	GO:1904761	negative regulation of myofibroblast differentiation	PDCD4	IMP		Human	PMID:20533548
Biological Process	GO:1905064	negative regulation of vascular associated smooth muscle cell differentiation	PDCD4	IDA		Human	PMID:18548003
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	PDCD4	IMP		Human	PMID:28522568
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	PDCD4	IMP		Human	PMID:24732886
Biological Process	GO:0050729	positive regulation of inflammatory response	Pdcd4	IMP		Mouse	MGI:MGI:4438829|PMID:19946272
Biological Process	GO:0050729	positive regulation of inflammatory response	Pdcd4	IMP		Mouse	MGI:MGI:3707264|PMID:17114484
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PDCD4	IMP		Human	PMID:19946272
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	Pdcd4	IMP		Rat	PMID:20357187|RGD:9589087
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	PDCD4	IMP		Human	PMID:28522568
Biological Process	GO:0051246	regulation of protein metabolic process	Pdcd4	IMP		Rat	PMID:21406616|RGD:9589089
Biological Process	GO:0043279	response to alkaloid	Pdcd4	IEP		Rat	PMID:30240970|RGD:156430315
Biological Process	GO:0009725	response to hormone	Pdcd4	IEP		Rat	PMID:30240970|RGD:156430315

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern