Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDCD6
  • Mouse genes Pdcd6
  • Rat genes Pdcd6
  • Zfish genes pdcd6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdcd6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	PDCD6	IDA		Human	PMID:25667979
Molecular Function	GO:0005509	calcium ion binding	Pdcd6	IMP		Mouse	MGI:MGI:3763292|PMID:17214967
Molecular Function	GO:0048306	calcium-dependent protein binding	PDCD6	IPI	UniProtKB:O94979	Human	PMID:16957052
Molecular Function	GO:0048306	calcium-dependent protein binding	PDCD6	IPI	UniProtKB:O94979	Human	PMID:17196169
Molecular Function	GO:0048306	calcium-dependent protein binding	PDCD6	IPI	UniProtKB:O94979	Human	PMID:17214967
Molecular Function	GO:0048306	calcium-dependent protein binding	PDCD6	IPI	UniProtKB:Q8WUM4	Human	PMID:18256029
Molecular Function	GO:0048306	calcium-dependent protein binding	PDCD6	IPI	UniProtKB:Q9NRY6	Human	PMID:18256029
Molecular Function	GO:0048306	calcium-dependent protein binding	PDCD6	IPI	UniProtKB:A5D8V6	Human	PMID:23924735
Molecular Function	GO:0048306	calcium-dependent protein binding	PDCD6	IPI	UniProtKB:Q8WUM4	Human	PMID:23924735
Molecular Function	GO:0048306	calcium-dependent protein binding	PDCD6	IPI	UniProtKB:Q9H9H4	Human	PMID:23924735
Molecular Function	GO:0048306	calcium-dependent protein binding	PDCD6	IPI	UniProtKB:Q9UBV8	Human	PMID:27716508
Molecular Function	GO:0048306	calcium-dependent protein binding	Pdcd6	IPI	UniProtKB:O94979	Mouse	MGI:MGI:3763292|PMID:17214967
Molecular Function	GO:0042802	identical protein binding	PDCD6	IPI	UniProtKB:O75340	Human	PMID:16189514
Molecular Function	GO:0042802	identical protein binding	PDCD6	IPI	UniProtKB:O75340	Human	PMID:18940611
Molecular Function	GO:0042802	identical protein binding	PDCD6	IPI	UniProtKB:O75340	Human	PMID:21988832
Molecular Function	GO:0042802	identical protein binding	PDCD6	IPI	UniProtKB:O75340	Human	PMID:25416956
Molecular Function	GO:0000287	magnesium ion binding	Pdcd6	IDA		Mouse	MGI:MGI:5883146|PMID:27541325
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:P50995	Human	PMID:11883939
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:P53355	Human	PMID:16132846
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q9UBV8	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q9Y5Z4	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q9H3S7	Human	PMID:17174262
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:O94979	Human	PMID:17196169
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q8WUM4	Human	PMID:17196169
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:O94979	Human	PMID:18256029
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:P20073	Human	PMID:18256029
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:P50995	Human	PMID:18256029
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q8WUM4	Human	PMID:18256029
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q99816	Human	PMID:18256029
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q9NRQ2	Human	PMID:18256029
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q9NRY6	Human	PMID:18256029
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q8WUM4	Human	PMID:18940611
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:P35968	Human	PMID:21893193
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q9UBV8	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:A5D8V6	Human	PMID:23924735
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:A5D8V6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q5T0G8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q9UBV8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q9Y5Z4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:O94979	Human	PMID:25667979
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q8WUM4	Human	PMID:25667979
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:P50995	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q13561	Human	PMID:26950892
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:O94979	Human	PMID:27716508
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q53G59	Human	PMID:27716508
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q9Y5Z4	Human	PMID:27784779
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q92734	Human	PMID:27813252
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:P50995	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q8WUM4	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:A5D8V6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:A6NJB7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:O95429	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q9UBV8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PDCD6	IPI	UniProtKB:Q9Y5Z4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pdcd6	IPI	UniProtKB:Q8N114	Mouse	MGI:MGI:5512839|PMID:17889823
Molecular Function	GO:0005515	protein binding	Pdcd6	IPI	UniProtKB:Q96A23	Mouse	MGI:MGI:5294308|PMID:12522145
Molecular Function	GO:0005515	protein binding	Pdcd6	IPI	UniProtKB:P25445	Mouse	MGI:MGI:4456958|PMID:11606059
Molecular Function	GO:0005515	protein binding	Pdcd6	IPI	PR:Q8C3Q9	Mouse	PMID:14561754
Molecular Function	GO:0005515	protein binding	Pdcd6	IPI	PR:O08736	Mouse	PMID:14561754
Molecular Function	GO:0046983	protein dimerization activity	PDCD6	IPI	UniProtKB:Q9UBV8	Human	PMID:11883899
Molecular Function	GO:0046983	protein dimerization activity	Pdcd6	IPI	UniProtKB:Q9WU78	Mouse	MGI:MGI:1333264|PMID:10200558
Molecular Function	GO:0042803	protein homodimerization activity	PDCD6	IDA		Human	PMID:25667979
Molecular Function	GO:0042803	protein homodimerization activity	Pdcd6	IPI	UniProtKB:P12815	Mouse	MGI:MGI:1333264|PMID:10200558
Molecular Function	GO:0042803	protein homodimerization activity	Pdcd6	IDA		Mouse	MGI:MGI:5883146|PMID:27541325
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	PDCD6	IMP		Human	PMID:19520058
Molecular Function	GO:0043495	protein-membrane adaptor activity	PDCD6	IMP		Human	PMID:16957052
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	PDCD6	IMP		Human	PMID:27716508
Cellular Component	GO:0030127	COPII vesicle coat	PDCD6	IDA		Human	PMID:27716508
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	PDCD6	IDA		Human	PMID:27716508
Cellular Component	GO:0005737	cytoplasm	PDCD6	IDA		Human	PMID:21122810
Cellular Component	GO:0005737	cytoplasm	PDCD6	IDA		Human	PMID:27784779
Cellular Component	GO:0005737	cytoplasm	Pdcd6	IDA		Mouse	MGI:MGI:3763292|PMID:17214967
Cellular Component	GO:0031410	cytoplasmic vesicle	PDCD6	IDA		Human	PMID:21122810
Cellular Component	GO:0005829	cytosol	PDCD6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	PDCD6	IDA		Human	PMID:17196169
Cellular Component	GO:0070971	endoplasmic reticulum exit site	PDCD6	IMP	UniProtKB:O94979	Human	PMID:16957052
Cellular Component	GO:0070971	endoplasmic reticulum exit site	PDCD6	IDA		Human	PMID:27813252
Cellular Component	GO:0070062	extracellular exosome	PDCD6	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	PDCD6	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	PDCD6	HDA		Human	PMID:23533145
Cellular Component	GO:0005654	nucleoplasm	PDCD6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PDCD6	IDA		Human	PMID:16957052
Cellular Component	GO:0005634	nucleus	PDCD6	IDA		Human	PMID:17196169
Cellular Component	GO:0005634	nucleus	PDCD6	IDA		Human	PMID:21122810
Cellular Component	GO:0005634	nucleus	PDCD6	IDA		Human	PMID:27784779
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Pdcd6	IDA		Mouse	PMID:14561754
Biological Process	GO:0006915	apoptotic process	Pdcd6	IDA		Mouse	PMID:8560270
Biological Process	GO:0034605	cellular response to heat	PDCD6	IDA		Human	PMID:21122810
Biological Process	GO:0048208	COPII vesicle coating	PDCD6	IMP		Human	PMID:27716508
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	PDCD6	IMP		Human	PMID:27716508
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	PDCD6	IMP		Human	PMID:27813252
Biological Process	GO:0006886	intracellular protein transport	PDCD6	IDA		Human	PMID:21122810
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PDCD6	IDA		Human	PMID:21893193
Biological Process	GO:0032007	negative regulation of TOR signaling	PDCD6	IDA		Human	PMID:21893193
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	PDCD6	IDA		Human	PMID:21893193
Biological Process	GO:0014032	neural crest cell development	PDCD6	IMP		Human	PMID:27716508
Biological Process	GO:0014029	neural crest formation	PDCD6	IMP		Human	PMID:27716508
Biological Process	GO:0045766	positive regulation of angiogenesis	PDCD6	IDA		Human	PMID:21893193
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PDCD6	IDA		Human	PMID:16132846
Biological Process	GO:0010595	positive regulation of endothelial cell migration	PDCD6	IDA		Human	PMID:21893193
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	PDCD6	IDA		Human	PMID:21893193
Biological Process	GO:1902527	positive regulation of protein monoubiquitination	PDCD6	IMP		Human	PMID:27716508
Biological Process	GO:0051592	response to calcium ion	Pdcd6	IDA		Mouse	MGI:MGI:3763292|PMID:17214967
Biological Process	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway	PDCD6	IDA		Human	PMID:21893193

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern