Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDE10A
  • Mouse genes Pde10a
  • Rat genes Pde10a
  • Zfish genes pde10a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde10a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	Pde10a	IMP		Mouse	MGI:MGI:5775673|PMID:27058446
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	Pde10a	IDA		Mouse	PMID:10359840
Molecular Function	GO:0030552	cAMP binding	PDE10A	IDA		Human	PMID:19689430
Molecular Function	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	PDE10A	IDA		Human	PMID:19689430
Molecular Function	GO:0004112	cyclic-nucleotide phosphodiesterase activity	Pde10a	IDA		Rat	PMID:10583409|RGD:68285
Molecular Function	GO:0004112	cyclic-nucleotide phosphodiesterase activity	Pde10a	IDA		Rat	PMID:14604994|RGD:2312517
Cellular Component	GO:0016020	membrane	Pde10a	IDA		Rat	PMID:14604994|RGD:2312517
Cellular Component	GO:0016020	membrane	Pde10a	IDA		Rat	PMID:16483723|RGD:2312515
Cellular Component	GO:0043025	neuronal cell body	Pde10a	IDA		Rat	PMID:12967715|RGD:2312516
Cellular Component	GO:0043204	perikaryon	Pde10a	IDA		Rat	PMID:19445908|RGD:2312501
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	Pde10a	IDA		Rat	PMID:10583409|RGD:68285
Biological Process	GO:0010754	negative regulation of cGMP-mediated signaling	Pde10a	IDA		Rat	PMID:10583409|RGD:68285
Biological Process	GO:0106070	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Pde10a	IMP		Mouse	PMID:18923023
Biological Process	GO:0010738	regulation of protein kinase A signaling	Pde10a	IMP		Mouse	PMID:18923023

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern