Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDE2A
  • Mouse genes Pde2a
  • Rat genes Pde2a
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE2A	IDA		Human	PMID:15938621
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE2A	IDA		Human	PMID:9210593
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde2a	IMP		Mouse	MGI:MGI:5294502|PMID:21724846
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	PDE2A	IDA		Human	PMID:15938621
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	PDE2A	IDA		Human	PMID:9210593
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Pde2a	IMP		Mouse	MGI:MGI:5294502|PMID:21724846
Molecular Function	GO:0030552	cAMP binding	PDE2A	IMP		Human	PMID:15938621
Molecular Function	GO:0030552	cAMP binding	Pde2a	IMP		Mouse	MGI:MGI:5294304|PMID:15210692
Molecular Function	GO:0030553	cGMP binding	PDE2A	IMP		Human	PMID:15938621
Molecular Function	GO:0030553	cGMP binding	PDE2A	IDA		Human	PMID:17329248
Molecular Function	GO:0030553	cGMP binding	PDE2A	IDA		Human	PMID:19689430
Molecular Function	GO:0030553	cGMP binding	PDE2A	IDA		Human	PMID:19828435
Molecular Function	GO:0030553	cGMP binding	Pde2a	IDA		Mouse	MGI:MGI:5294310|PMID:12271124
Molecular Function	GO:0030553	cGMP binding	Pde2a	IMP		Mouse	MGI:MGI:5294304|PMID:15210692
Molecular Function	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	PDE2A	IDA		Human	PMID:17329248
Molecular Function	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	PDE2A	IDA		Human	PMID:19689430
Molecular Function	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	Pde2a	IDA		Mouse	MGI:MGI:5294304|PMID:15210692
Molecular Function	GO:0036004	GAF domain binding	Pde2a	IDA		Mouse	MGI:MGI:5294310|PMID:12271124
Molecular Function	GO:0042802	identical protein binding	Pde2a	IPI	RGD:620965	Rat	PMID:12573460|RGD:2312526
Molecular Function	GO:0000287	magnesium ion binding	PDE2A	IDA		Human	PMID:15938621
Molecular Function	GO:0042301	phosphate ion binding	PDE2A	IDA		Human	PMID:15938621
Molecular Function	GO:0005515	protein binding	PDE2A	IPI	UniProtKB:O00170	Human	PMID:17329248
Molecular Function	GO:0005515	protein binding	Pde2a	IPI	UniProtKB:Q5FWY5	Rat	PMID:17329248|RGD:8553813
Molecular Function	GO:0042803	protein homodimerization activity	PDE2A	IPI	UniProtKB:O00408	Human	PMID:19828435
Molecular Function	GO:0042803	protein homodimerization activity	Pde2a	IDA		Mouse	MGI:MGI:5294310|PMID:12271124
Molecular Function	GO:0030911	TPR domain binding	PDE2A	IPI	UniProtKB:O00170	Human	PMID:17329248
Molecular Function	GO:0008270	zinc ion binding	PDE2A	IDA		Human	PMID:15938621
Cellular Component	GO:0030424	axon	Pde2a	IDA		Mouse	PMID:8586960
Cellular Component	GO:0005737	cytoplasm	PDE2A	IDA		Human	PMID:10375378
Cellular Component	GO:0005737	cytoplasm	PDE2A	IDA		Human	PMID:19506089
Cellular Component	GO:0005737	cytoplasm	Pde2a	IDA		Mouse	MGI:MGI:5294515|PMID:21571906
Cellular Component	GO:0005737	cytoplasm	Pde2a	IDA		Mouse	MGI:MGI:4367324|PMID:19506089
Cellular Component	GO:0005737	cytoplasm	Pde2a	IDA		Rat	PMID:19506089|RGD:8554511
Cellular Component	GO:0005737	cytoplasm	Pde2a	IDA		Rat	PMID:28463107|RGD:13210537
Cellular Component	GO:0005829	cytosol	PDE2A	IDA		Human	PMID:17329248
Cellular Component	GO:0005829	cytosol	Pde2a	IDA		Mouse	MGI:MGI:4420377|PMID:19632989
Cellular Component	GO:0005829	cytosol	Pde2a	IDA		Mouse	PMID:17329248
Cellular Component	GO:0030425	dendrite	Pde2a	IDA		Mouse	PMID:8586960
Cellular Component	GO:0005783	endoplasmic reticulum	Pde2a	IDA		Mouse	MGI:MGI:4420377|PMID:19632989
Cellular Component	GO:0005794	Golgi apparatus	Pde2a	IDA		Mouse	MGI:MGI:4420377|PMID:19632989
Cellular Component	GO:0097457	hippocampal mossy fiber	Pde2a	IDA		Rat	PMID:19506089|RGD:8554511
Cellular Component	GO:0045121	membrane raft	Pde2a	IDA		Rat	PMID:12573460|RGD:2312526
Cellular Component	GO:0005743	mitochondrial inner membrane	PDE2A	IDA		Human	PMID:28463107
Cellular Component	GO:0005743	mitochondrial inner membrane	Pde2a	IDA		Mouse	MGI:MGI:5908487|PMID:28463107
Cellular Component	GO:0005743	mitochondrial inner membrane	Pde2a	IDA		Rat	PMID:28463107|RGD:13210537
Cellular Component	GO:0005759	mitochondrial matrix	Pde2a	IDA		Mouse	MGI:MGI:5294502|PMID:21724846
Cellular Component	GO:0005759	mitochondrial matrix	Pde2a	IDA		Rat	PMID:21724846|RGD:8553746
Cellular Component	GO:0005759	mitochondrial matrix	Pde2a	IDA		Rat	PMID:24012591|RGD:10449439
Cellular Component	GO:0005741	mitochondrial outer membrane	PDE2A	IDA		Human	PMID:28463107
Cellular Component	GO:0005741	mitochondrial outer membrane	Pde2a	IDA		Mouse	MGI:MGI:5908487|PMID:28463107
Cellular Component	GO:0005741	mitochondrial outer membrane	Pde2a	IDA		Rat	PMID:28463107|RGD:13210537
Cellular Component	GO:0005739	mitochondrion	Pde2a	IDA		Mouse	MGI:MGI:5908487|PMID:28463107
Cellular Component	GO:0005739	mitochondrion	Pde2a	IDA		Rat	PMID:28463107|RGD:13210537
Cellular Component	GO:0005634	nucleus	PDE2A	IDA		Human	PMID:10375378
Cellular Component	GO:0005634	nucleus	Pde2a	IDA		Mouse	MGI:MGI:4420377|PMID:19632989
Cellular Component	GO:0005634	nucleus	Pde2a	IDA		Rat	PMID:19506089|RGD:8554511
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PDE2A	IDA		Human	PMID:10375378
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Pde2a	IDA		Mouse	MGI:MGI:4420377|PMID:19632989
Cellular Component	GO:0005886	plasma membrane	PDE2A	IDA		Human	PMID:17329248
Cellular Component	GO:0005886	plasma membrane	PDE2A	IDA		Human	PMID:19252089
Cellular Component	GO:0005886	plasma membrane	Pde2a	IDA		Mouse	MGI:MGI:4420377|PMID:19632989
Cellular Component	GO:0005886	plasma membrane	Pde2a	IDA		Rat	PMID:28463107|RGD:13210537
Cellular Component	GO:0042734	presynaptic membrane	Pde2a	IDA		Mouse	MGI:MGI:4367324|PMID:19506089
Cellular Component	GO:0097060	synaptic membrane	Pde2a	IDA		Rat	PMID:12573460|RGD:2312526
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	PDE2A	IDA		Human	PMID:17329248
Biological Process	GO:0035904	aorta development	Pde2a	IMP		Mouse	PMID:25807483
Biological Process	GO:0019933	cAMP-mediated signaling	PDE2A	IMP		Human	PMID:17704206
Biological Process	GO:0019933	cAMP-mediated signaling	Pde2a	IDA		Mouse	MGI:MGI:5294304|PMID:15210692
Biological Process	GO:0003279	cardiac septum development	Pde2a	IMP		Mouse	PMID:25807483
Biological Process	GO:1904613	cellular response to 2,3,7,8-tetrachlorodibenzodioxine	PDE2A	IDA		Human	PMID:17329248
Biological Process	GO:0071320	cellular response to cAMP	PDE2A	IDA		Human	PMID:17329248
Biological Process	GO:0071321	cellular response to cGMP	PDE2A	IDA		Human	PMID:17704206
Biological Process	GO:0071321	cellular response to cGMP	PDE2A	IDA		Human	PMID:19828435
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Pde2a	IEP		Mouse	MGI:MGI:5294515|PMID:21571906
Biological Process	GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	PDE2A	IDA		Human	PMID:14687666
Biological Process	GO:0071260	cellular response to mechanical stimulus	Pde2a	IDA		Mouse	MGI:MGI:5294515|PMID:21571906
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	PDE2A	IEP		Human	PMID:17704206
Biological Process	GO:0046069	cGMP catabolic process	PDE2A	IDA		Human	PMID:19828435
Biological Process	GO:0046069	cGMP catabolic process	Pde2a	IMP		Mouse	MGI:MGI:4420377|PMID:19632989
Biological Process	GO:0019934	cGMP-mediated signaling	PDE2A	IMP		Human	PMID:17704206
Biological Process	GO:0019934	cGMP-mediated signaling	Pde2a	IDA		Mouse	MGI:MGI:5294304|PMID:15210692
Biological Process	GO:0060976	coronary vasculature development	Pde2a	IMP		Mouse	PMID:25807483
Biological Process	GO:0061028	establishment of endothelial barrier	Pde2a	IDA		Rat	PMID:20139324|RGD:8553884
Biological Process	GO:0007507	heart development	Pde2a	IMP		Mouse	PMID:25807483
Biological Process	GO:0003170	heart valve development	Pde2a	IMP		Mouse	PMID:25807483
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	PDE2A	IMP		Human	PMID:19252089
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	Pde2a	IMP		Mouse	MGI:MGI:5294502|PMID:21724846
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	Pde2a	IMP		Mouse	MGI:MGI:5294515|PMID:21571906
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	Pde2a	IDA		Rat	PMID:12107056|RGD:625635
Biological Process	GO:0060548	negative regulation of cell death	Pde2a	IMP		Mouse	MGI:MGI:5908487|PMID:28463107
Biological Process	GO:0060548	negative regulation of cell death	Pde2a	IMP		Rat	PMID:28463107|RGD:13210537
Biological Process	GO:0010754	negative regulation of cGMP-mediated signaling	Pde2a	IMP		Mouse	MGI:MGI:5294502|PMID:21724846
Biological Process	GO:0090324	negative regulation of oxidative phosphorylation	Pde2a	IMP		Mouse	MGI:MGI:5294502|PMID:21724846
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	PDE2A	IDA		Human	PMID:17329248
Biological Process	GO:0043116	negative regulation of vascular permeability	PDE2A	IMP		Human	PMID:17704206
Biological Process	GO:0010628	positive regulation of gene expression	Pde2a	IMP		Mouse	MGI:MGI:5294515|PMID:21571906
Biological Process	GO:0050729	positive regulation of inflammatory response	Pde2a	IMP		Mouse	MGI:MGI:5294515|PMID:21571906
Biological Process	GO:0043117	positive regulation of vascular permeability	PDE2A	IMP		Human	PMID:17704206
Biological Process	GO:0043949	regulation of cAMP-mediated signaling	PDE2A	IMP		Human	PMID:15938621
Biological Process	GO:0010752	regulation of cGMP-mediated signaling	PDE2A	IMP		Human	PMID:15938621
Biological Process	GO:0010821	regulation of mitochondrion organization	Pde2a	IMP		Mouse	MGI:MGI:5908487|PMID:28463107
Biological Process	GO:0010821	regulation of mitochondrion organization	Pde2a	IMP		Rat	PMID:28463107|RGD:13210537
Biological Process	GO:0010749	regulation of nitric oxide mediated signal transduction	Pde2a	IGI	MGI:MGI:2651499	Mouse	PMID:16150726
Biological Process	GO:1904880	response to hydrogen sulfide	Pde2a	IEP		Rat	PMID:24012591|RGD:10449439
Biological Process	GO:0003281	ventricular septum development	Pde2a	IMP		Mouse	PMID:25807483

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern