Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDE3A
  • Mouse genes Pde3a
  • Rat genes Pde3a
  • Zfish genes pde3a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE3A	IDA		Human	PMID:8155697
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde3a	IDA		Mouse	PMID:11420239
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	PDE3A	IDA		Human	PMID:8155697
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE3A	IDA		Human	PMID:27975297
Molecular Function	GO:0004119	cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	PDE3A	IDA		Human	PMID:8155697
Molecular Function	GO:0099130	estrogen binding	PDE3A	IDA		Human	PMID:31420216
Molecular Function	GO:0030284	nuclear estrogen receptor activity	PDE3A	IDA		Human	PMID:31420216
Molecular Function	GO:0030284	nuclear estrogen receptor activity	PDE3A	IDA		Human	PMID:35104454
Molecular Function	GO:0005515	protein binding	PDE3A	IPI	UniProtKB:Q9Y6D5	Human	PMID:19332778
Molecular Function	GO:0005515	protein binding	PDE3A	IPI	UniProtKB:Q9Y6D6	Human	PMID:19332778
Molecular Function	GO:0005515	protein binding	PDE3A	IPI	UniProtKB:Q8IYM2	Human	PMID:31420216
Molecular Function	GO:0005515	protein binding	PDE3A	IPI	UniProtKB:Q8IYM2	Human	PMID:34272366
Molecular Function	GO:0005515	protein binding	PDE3A	IPI	UniProtKB:Q8IYM2	Human	PMID:35104454
Cellular Component	GO:0005829	cytosol	PDE3A	IDA		Human	PMID:35104454
Cellular Component	GO:0005829	cytosol	Pde3a	IDA		Mouse	PMID:23008439
Cellular Component	GO:0005829	cytosol	Pde3a	IDA		Rat	PMID:11916944|RGD:2300414
Cellular Component	GO:0005829	cytosol	Pde3a	IDA		Rat	PMID:9884079|RGD:2312525
Cellular Component	GO:0016020	membrane	Pde3a	IDA		Mouse	PMID:23008439
Biological Process	GO:0097190	apoptotic signaling pathway	PDE3A	IDA		Human	PMID:31420216
Biological Process	GO:0097190	apoptotic signaling pathway	PDE3A	IMP		Human	PMID:31420216
Biological Process	GO:0097190	apoptotic signaling pathway	PDE3A	IMP		Human	PMID:35104454
Biological Process	GO:0019933	cAMP-mediated signaling	PDE3A	IMP		Human	PMID:17704206
Biological Process	GO:0071321	cellular response to cGMP	PDE3A	IDA		Human	PMID:17704206
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	PDE3A	IEP		Human	PMID:17704206
Biological Process	GO:0019934	cGMP-mediated signaling	PDE3A	IMP		Human	PMID:17704206
Biological Process	GO:0043066	negative regulation of apoptotic process	Pde3a	IMP		Rat	PMID:15867171|RGD:2300419
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	PDE3A	IMP		Human	PMID:19252089
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	Pde3a	IMP		Rat	PMID:9884079|RGD:2312525
Biological Process	GO:0043116	negative regulation of vascular permeability	PDE3A	IMP		Human	PMID:17704206
Biological Process	GO:0048599	oocyte development	Pde3a	IGI	MGI:MGI:2651499	Mouse	PMID:19474061
Biological Process	GO:0001556	oocyte maturation	Pde3a	IDA		Mouse	PMID:11420239
Biological Process	GO:0001556	oocyte maturation	Pde3a	IEP		Rat	PMID:11673261|RGD:731220
Biological Process	GO:0060282	positive regulation of oocyte development	Pde3a	IGI	MGI:MGI:2651499	Mouse	PMID:19474061
Biological Process	GO:0043117	positive regulation of vascular permeability	PDE3A	IMP		Human	PMID:17704206
Biological Process	GO:0040020	regulation of meiotic nuclear division	Pde3a	IDA		Mouse	PMID:11420239
Biological Process	GO:0060700	regulation of ribonuclease activity	PDE3A	IDA		Human	PMID:34272366
Biological Process	GO:0060700	regulation of ribonuclease activity	PDE3A	IMP		Human	PMID:35104454
Biological Process	GO:0009410	response to xenobiotic stimulus	Pde3a	IDA		Mouse	PMID:11420239

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern