Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDE4A
  • Mouse genes Pde4a
  • Rat genes Pde4a
  • Zfish genes pde4a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde4a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE4A	IDA		Human	PMID:17404263
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE4A	IGI	UniProtKB:P06776|UniProtKB:P22434	Human	PMID:8413254
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde4a	IDA		Mouse	MGI:MGI:5286798|PMID:21670503
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde4a	IDA		Mouse	MGI:MGI:1927461|PMID:11267656
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde4a	IDA		Rat	PMID:21323643|RGD:151356649
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde4a	IDA		Rat	PMID:8557632|RGD:633604
Molecular Function	GO:0030552	cAMP binding	PDE4A	IGI	UniProtKB:P06776|UniProtKB:P22434	Human	PMID:8413254
Molecular Function	GO:0005515	protein binding	PDE4A	IPI	UniProtKB:P07948	Human	PMID:11306681
Molecular Function	GO:0005515	protein binding	Pde4a	IPI	RGD:628619	Rat	PMID:12810716|RGD:632260
Cellular Component	GO:0005737	cytoplasm	Pde4a	IDA		Mouse	PMID:19305400
Cellular Component	GO:0005737	cytoplasm	Pde4a	IDA		Rat	PMID:15242814|RGD:2302432
Cellular Component	GO:0005829	cytosol	Pde4a	IDA		Mouse	PMID:23008439
Cellular Component	GO:0005829	cytosol	Pde4a	IDA		Rat	PMID:12810716|RGD:632260
Cellular Component	GO:0005829	cytosol	Pde4a	IDA		Rat	PMID:8557632|RGD:633604
Cellular Component	GO:0019898	extrinsic component of membrane	Pde4a	IDA		Rat	PMID:8557632|RGD:633604
Cellular Component	GO:0016020	membrane	Pde4a	IDA		Mouse	PMID:23008439
Cellular Component	GO:0005654	nucleoplasm	PDE4A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Pde4a	IDA		Rat	PMID:15242814|RGD:2302432
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PDE4A	IDA		Human	PMID:11306681
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Pde4a	IDA		Rat	PMID:15242814|RGD:2302432
Cellular Component	GO:0005886	plasma membrane	PDE4A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Pde4a	IDA		Rat	PMID:27559174|RGD:13702343
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Pde4a	IMP		Rat	PMID:27559174|RGD:13702343
Biological Process	GO:0006198	cAMP catabolic process	Pde4a	IDA		Mouse	MGI:MGI:1927461|PMID:11267656
Biological Process	GO:0006198	cAMP catabolic process	Pde4a	IDA		Rat	PMID:21323643|RGD:151356649
Biological Process	GO:0006198	cAMP catabolic process	Pde4a	IDA		Rat	PMID:8557632|RGD:633604
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Pde4a	IDA		Mouse	PMID:11267656
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Pde4a	IDA		Rat	PMID:27559174|RGD:13702343
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Pde4a	IMP		Rat	PMID:27559174|RGD:13702343
Biological Process	GO:0106070	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Pde4a	IMP		Mouse	PMID:18923023
Biological Process	GO:0010738	regulation of protein kinase A signaling	Pde4a	IMP		Mouse	PMID:18923023
Biological Process	GO:0009410	response to xenobiotic stimulus	Pde4a	IEP		Rat	PMID:16190900|RGD:2302430
Biological Process	GO:0007608	sensory perception of smell	Pde4a	IGI	MGI:MGI:108413	Mouse	PMID:19305400

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern