Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDE4B
  • Mouse genes Pde4b
  • Rat genes Pde4b
  • Zfish genes pde4ba,pde4bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde4b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE4B	IDA		Human	PMID:17404263
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE4B	IGI	UniProtKB:P06776|UniProtKB:P22434	Human	PMID:8413254
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde4b	IDA		Mouse	MGI:MGI:5286798|PMID:21670503
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde4b	IDA		Rat	PMID:12441002|RGD:633623
Molecular Function	GO:0030552	cAMP binding	PDE4B	IGI	UniProtKB:P06776|UniProtKB:P22434	Human	PMID:8413254
Molecular Function	GO:0043015	gamma-tubulin binding	Pde4b	IDA		Mouse	PMID:18983980
Molecular Function	GO:0005515	protein binding	Pde4b	IPI	PR:Q06507	Mouse	PMID:18983980
Molecular Function	GO:0005515	protein binding	Pde4b	IPI	PR:Q811T9	Mouse	PMID:18983980
Molecular Function	GO:0005515	protein binding	Pde4b	IPI	PR:P63005	Mouse	PMID:18983980
Molecular Function	GO:0005515	protein binding	Pde4b	IPI	PR:Q01063	Mouse	PMID:18983980
Molecular Function	GO:0005515	protein binding	Pde4b	IPI	PR:Q9CZA6	Mouse	PMID:18983980
Molecular Function	GO:0005515	protein binding	Pde4b	IPI	PR:Q9ERR1	Mouse	PMID:18983980
Molecular Function	GO:0044325	transmembrane transporter binding	Pde4b	IPI	UniProtKB:Q01815	Mouse	MGI:MGI:5286798|PMID:21670503
Cellular Component	GO:0071944	cell periphery	Pde4b	IDA		Mouse	PMID:18923023
Cellular Component	GO:0005813	centrosome	Pde4b	IDA		Mouse	PMID:18983980
Cellular Component	GO:0005737	cytoplasm	Pde4b	IDA		Rat	PMID:15242814|RGD:2302432
Cellular Component	GO:0005829	cytosol	Pde4b	IDA		Mouse	PMID:23008439
Cellular Component	GO:0005829	cytosol	Pde4b	IDA		Rat	PMID:12441002|RGD:633623
Cellular Component	GO:0043197	dendritic spine	Pde4b	IDA		Mouse	PMID:18983980
Cellular Component	GO:0060076	excitatory synapse	Pde4b	IDA		Mouse	PMID:18983980
Cellular Component	GO:0000930	gamma-tubulin complex	Pde4b	IDA		Mouse	PMID:18983980
Cellular Component	GO:0016020	membrane	Pde4b	IDA		Mouse	PMID:23008439
Cellular Component	GO:0005634	nucleus	Pde4b	IDA		Rat	PMID:15242814|RGD:2302432
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Pde4b	IDA		Rat	PMID:15242814|RGD:2302432
Cellular Component	GO:0014069	postsynaptic density	Pde4b	IDA		Mouse	PMID:18983980
Cellular Component	GO:0008021	synaptic vesicle	Pde4b	IDA		Mouse	PMID:18983980
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Pde4b	IDA		Mouse	MGI:MGI:5286798|PMID:21670503
Cellular Component	GO:0030018	Z disc	Pde4b	IMP		Mouse	MGI:MGI:5286798|PMID:21670503
Biological Process	GO:0071872	cellular response to epinephrine stimulus	Pde4b	IMP		Mouse	MGI:MGI:5286798|PMID:21670503
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Pde4b	IMP	MGI:MGI:2181444	Mouse	PMID:15585880
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Pde4b	IDA		Mouse	PMID:11267656
Biological Process	GO:0050900	leukocyte migration	Pde4b	IMP	MGI:MGI:2181444	Mouse	PMID:15585880
Biological Process	GO:0140199	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	Pde4b	IMP		Mouse	MGI:MGI:5286798|PMID:21670503
Biological Process	GO:1901898	negative regulation of relaxation of cardiac muscle	Pde4b	IMP		Mouse	MGI:MGI:5286798|PMID:21670503
Biological Process	GO:0030593	neutrophil chemotaxis	Pde4b	IMP	MGI:MGI:2181444	Mouse	PMID:15585880
Biological Process	GO:0001780	neutrophil homeostasis	Pde4b	IMP	MGI:MGI:2181444	Mouse	PMID:15585880
Biological Process	GO:0032743	positive regulation of interleukin-2 production	PDE4B	IMP		Human	PMID:17404263
Biological Process	GO:0032729	positive regulation of type II interferon production	PDE4B	IMP		Human	PMID:17404263
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Pde4b	IMP		Mouse	MGI:MGI:5286798|PMID:21670503
Biological Process	GO:1901841	regulation of high voltage-gated calcium channel activity	Pde4b	IMP		Mouse	MGI:MGI:5286798|PMID:21670503
Biological Process	GO:0009408	response to heat	Pde4b	IMP		Rat	PMID:29693432|RGD:13782127
Biological Process	GO:0050852	T cell receptor signaling pathway	PDE4B	IMP		Human	PMID:17404263

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern