Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDGFA
  • Mouse genes Pdgfa
  • Rat genes Pdgfa
  • Zfish genes pdgfaa,pdgfab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdgfa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	PDGFA	IDA		Human	PMID:8900172
Molecular Function	GO:0008083	growth factor activity	PDGFA	IDA		Human	PMID:12070119
Molecular Function	GO:0048407	platelet-derived growth factor binding	PDGFA	IPI	UniProtKB:P01127	Human	PMID:7073684
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	PDGFA	IDA		Human	PMID:2439522
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	PDGFA	IPI	UniProtKB:P16234	Human	PMID:2536956
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	PDGFA	IDA		Human	PMID:2836953
Molecular Function	GO:0005515	protein binding	PDGFA	IPI	UniProtKB:P16234	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	PDGFA	IPI	UniProtKB:P16234	Human	PMID:7679113
Molecular Function	GO:0046982	protein heterodimerization activity	PDGFA	IPI	UniProtKB:P01127	Human	PMID:7073684
Molecular Function	GO:0042803	protein homodimerization activity	PDGFA	IDA		Human	PMID:2836953
Molecular Function	GO:0042803	protein homodimerization activity	PDGFA	IDA		Human	PMID:3754619
Cellular Component	GO:0009986	cell surface	PDGFA	IDA		Human	PMID:2538439
Cellular Component	GO:0009986	cell surface	PDGFA	IDA		Human	PMID:2836953
Cellular Component	GO:0009986	cell surface	PDGFA	IDA		Human	PMID:291037
Cellular Component	GO:0005615	extracellular space	PDGFA	IDA		Human	PMID:3754619
Cellular Component	GO:0005615	extracellular space	Pdgfa	IDA		Mouse	MGI:MGI:4820704|PMID:19734317
Cellular Component	GO:0005902	microvillus	Pdgfa	IDA		Mouse	PMID:12101409
Cellular Component	GO:1990265	platelet-derived growth factor complex	PDGFA	IPI		Human	PMID:7679113
Biological Process	GO:0030036	actin cytoskeleton organization	Pdgfa	IDA		Mouse	PMID:12176888
Biological Process	GO:0001525	angiogenesis	Pdgfa	IDA		Mouse	PMID:12101409
Biological Process	GO:0001525	angiogenesis	pdgfaa	IMP	ZFIN:ZDB-FISH-201029-8	Zfish	PMID:31974005
Biological Process	GO:0001525	angiogenesis	pdgfab	IMP	ZFIN:ZDB-FISH-201029-8	Zfish	PMID:31974005
Biological Process	GO:0009887	animal organ morphogenesis	Pdgfa	IGI	MGI:MGI:1859631	Mouse	PMID:15361870
Biological Process	GO:0009887	animal organ morphogenesis	Pdgfa	IMP	MGI:MGI:1926817	Mouse	PMID:14522834
Biological Process	GO:0060348	bone development	Pdgfa	IGI	MGI:MGI:1859631	Mouse	PMID:23938297
Biological Process	GO:0003261	cardiac muscle progenitor cell migration to the midline involved in heart field formation	pdgfaa	IMP	ZFIN:ZDB-GENO-170510-4	Zfish	PMID:28098558
Biological Process	GO:0008283	cell population proliferation	Pdgfa	IMP	MGI:MGI:1926817	Mouse	PMID:10331973
Biological Process	GO:0030031	cell projection assembly	Pdgfa	IDA		Mouse	PMID:12176888
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Pdgfa	IEP		Rat	PMID:16039137|RGD:1581755
Biological Process	GO:0048565	digestive tract development	Pdgfa	IMP		Mouse	MGI:MGI:1860627|PMID:10903171
Biological Process	GO:0048565	digestive tract development	Pdgfa	IGI	MGI:MGI:1859631	Mouse	PMID:23938297
Biological Process	GO:1990401	embryonic lung development	Pdgfa	IMP		Mouse	MGI:MGI:1098909|PMID:9374392
Biological Process	GO:0001942	hair follicle development	Pdgfa	IMP	MGI:MGI:1926817	Mouse	PMID:10331973
Biological Process	GO:0048839	inner ear development	Pdgfa	IEP		Rat	PMID:15267171|RGD:2292167
Biological Process	GO:0048286	lung alveolus development	Pdgfa	IMP		Mouse	MGI:MGI:1098909|PMID:9374392
Biological Process	GO:0048286	lung alveolus development	Pdgfa	IMP	MGI:MGI:5548172	Mouse	PMID:23938297
Biological Process	GO:0048286	lung alveolus development	Pdgfa	IMP	MGI:MGI:1926817	Mouse	PMID:11803579
Biological Process	GO:0008584	male gonad development	Pdgfa	IEP		Rat	PMID:11870082|RGD:11087559
Biological Process	GO:0007275	multicellular organism development	pdgfaa	IEP		Zfish	PMID:12211169
Biological Process	GO:0050919	negative chemotaxis	PDGFA	IDA		Human	PMID:9409235
Biological Process	GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	PDGFA	IDA		Human	PMID:2538439
Biological Process	GO:0010544	negative regulation of platelet activation	PDGFA	IDA		Human	PMID:2538439
Biological Process	GO:0001755	neural crest cell migration	pdgfaa	IMP	ZFIN:ZDB-MRPHLNO-191017-1	Zfish	PMID:30031069
Biological Process	GO:0001755	neural crest cell migration	pdgfaa	IGI	ZFIN:ZDB-GENE-030918-2	Zfish	PMID:30031069
Biological Process	GO:0001755	neural crest cell migration	pdgfaa	IMP	ZFIN:ZDB-MRPHLNO-130813-2	Zfish	PMID:30031069
Biological Process	GO:0001755	neural crest cell migration	pdgfaa	IGI	ZFIN:ZDB-GENE-040426-706	Zfish	PMID:30031069
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	PDGFA	IDA		Human	PMID:2439522
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	PDGFA	IDA		Human	PMID:2536956
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	PDGFA	IDA		Human	PMID:2836953
Biological Process	GO:0030335	positive regulation of cell migration	PDGFA	IDA		Human	PMID:11788434
Biological Process	GO:0030335	positive regulation of cell migration	PDGFA	IDA		Human	PMID:17470632
Biological Process	GO:0008284	positive regulation of cell population proliferation	PDGFA	IDA		Human	PMID:16462734
Biological Process	GO:0008284	positive regulation of cell population proliferation	PDGFA	IDA		Human	PMID:10806482
Biological Process	GO:0008284	positive regulation of cell population proliferation	PDGFA	IDA		Human	PMID:17470632
Biological Process	GO:0008284	positive regulation of cell population proliferation	PDGFA	IDA		Human	PMID:2439522
Biological Process	GO:0008284	positive regulation of cell population proliferation	PDGFA	IDA		Human	PMID:2836953
Biological Process	GO:0008284	positive regulation of cell population proliferation	PDGFA	IDA		Human	PMID:7073684
Biological Process	GO:0008284	positive regulation of cell population proliferation	Pdgfa	IMP	MGI:MGI:1926817	Mouse	PMID:10331973
Biological Process	GO:0008284	positive regulation of cell population proliferation	Pdgfa	IMP		Rat	PMID:15267171|RGD:2292167
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PDGFA	IDA		Human	PMID:11788434
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	PDGFA	IDA		Human	PMID:10806482
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	PDGFA	IDA		Human	PMID:2439522
Biological Process	GO:0043406	positive regulation of MAP kinase activity	PDGFA	IDA		Human	PMID:11788434
Biological Process	GO:0043410	positive regulation of MAPK cascade	PDGFA	IMP		Human	PMID:11788434
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Pdgfa	IMP	MGI:MGI:1926817	Mouse	PMID:10331973
Biological Process	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	PDGFA	IDA		Human	PMID:19019919
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PDGFA	IDA		Human	PMID:11788434
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	PDGFA	IDA		Human	PMID:12070119
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	PDGFA	IDA		Human	PMID:19019919
Biological Process	GO:0060683	regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	Pdgfa	IMP		Mouse	PMID:18559345
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Pdgfa	IDA		Mouse	PMID:11940581
Biological Process	GO:0014910	regulation of smooth muscle cell migration	PDGFA	IDA		Human	PMID:9409235
Biological Process	GO:0032355	response to estradiol	Pdgfa	IEP		Rat	PMID:14724432|RGD:2292171
Biological Process	GO:0001666	response to hypoxia	Pdgfa	IEP		Rat	PMID:8447423|RGD:1580847
Biological Process	GO:0010035	response to inorganic substance	Pdgfa	IEP		Rat	PMID:17134509|RGD:2292160
Biological Process	GO:0010033	response to organic substance	Pdgfa	IEP		Rat	PMID:17134509|RGD:2292160
Biological Process	GO:0032526	response to retinoic acid	Pdgfa	IEP		Rat	PMID:15315332|RGD:2292166
Biological Process	GO:0009611	response to wounding	PDGFA	IDA		Human	PMID:2538439
Biological Process	GO:0009410	response to xenobiotic stimulus	Pdgfa	IEP		Rat	PMID:16414398|RGD:2292162
Biological Process	GO:0043588	skin development	Pdgfa	IMP	MGI:MGI:1926817	Mouse	PMID:10331973
Biological Process	GO:0042060	wound healing	Pdgfa	IEP		Rat	PMID:18205704|RGD:2292158

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern