Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDHA2
  • Mouse genes Pdha2
  • Rat genes Pdha2
  • Zfish genes pdha1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdha2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PDHA2	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	PDHA2	IDA		Human	PMID:16436377
Molecular Function	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	Pdha2	IDA		Rat	PMID:7487891|RGD:1599112
Cellular Component	GO:0005739	mitochondrion	PDHA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Pdha2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Pdha2	IDA		Rat	PMID:7487891|RGD:1599112
Cellular Component	GO:0005730	nucleolus	PDHA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PDHA2	HDA		Human	PMID:21630459
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	Pdha2	IDA		Rat	PMID:7487891|RGD:1599112
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Pdha2	IDA		Rat	PMID:7487891|RGD:1599112
Biological Process	GO:0006090	pyruvate metabolic process	PDHA2	IDA		Human	PMID:16436377

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern