Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDHB
  • Mouse genes Pdhb
  • Rat genes Pdhb
  • Zfish genes pdhb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdhb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PDHB	IPI	UniProtKB:P08559	Human	PMID:12651851
Molecular Function	GO:0005515	protein binding	PDHB	IPI	UniProtKB:P10515	Human	PMID:18206651
Molecular Function	GO:0005515	protein binding	PDHB	IPI	UniProtKB:P08559	Human	PMID:29128334
Molecular Function	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	PDHB	IDA		Human	PMID:19081061
Molecular Function	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	Pdhb	IDA		Rat	PMID:7487891|RGD:1599112
Molecular Function	GO:0034604	pyruvate dehydrogenase (NAD+) activity	PDHB	IDA		Human	PMID:18164639
Molecular Function	GO:0004738	pyruvate dehydrogenase activity	pdhb	IMP	ZFIN:ZDB-GENO-100921-2	Zfish	PMID:20826660
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	PDHB	IPI		Human	PMID:19240034
Cellular Component	GO:0005739	mitochondrion	PDHB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Pdhb	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Pdhb	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Pdhb	IDA		Rat	PMID:7487891|RGD:1599112
Cellular Component	GO:0005654	nucleoplasm	PDHB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PDHB	HDA		Human	PMID:21630459
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	PDHB	IDA		Human	PMID:19081061
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	Pdhb	IDA		Rat	PMID:7487891|RGD:1599112
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	PDHB	IDA		Human	PMID:19081061
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	PDHB	IDA		Human	PMID:24534072
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Pdhb	IDA		Rat	PMID:7487891|RGD:1599112
Biological Process	GO:0043473	pigmentation	pdhb	IMP	ZFIN:ZDB-GENO-100921-1	Zfish	PMID:9007256
Biological Process	GO:0043473	pigmentation	pdhb	IMP	ZFIN:ZDB-GENO-100921-2	Zfish	PMID:9007256

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern