Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDIA3
  • Mouse genes Pdia3
  • Rat genes Pdia3
  • Zfish genes pdia3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdia3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	PDIA3	IPI	UniProtKB:P30101	Human	PMID:16905107
Molecular Function	GO:0042288	MHC class I protein binding	Pdia3	IDA		Rat	PMID:9637924|RGD:9999147
Molecular Function	GO:0008233	peptidase activity	Pdia3	IDA		Rat	PMID:1330685|RGD:9999188
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:P05067	Human	PMID:15896298
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:P24643	Human	PMID:16905107
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:Q03518	Human	PMID:17055437
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:P10909	Human	PMID:17170699
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:Q96HE7	Human	PMID:17170699
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:Q99JC6	Human	PMID:17947644
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:Q86YB8	Human	PMID:20802462
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:Q96HE7	Human	PMID:20802462
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:Q13162	Human	PMID:21057456
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:O00182,UniProtKB:P07237,UniProtKB:Q15084	Human	PMID:21670307
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:Q13586	Human	PMID:21941299
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:P18418	Human	PMID:22665516
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:P01009	Human	PMID:23826168
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:P20848	Human	PMID:23826168
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:P10909	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:Q03518	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	PDIA3	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Pdia3	IPI	UniProtKB:Q9D8I1	Mouse	MGI:MGI:4866969|PMID:21093319
Molecular Function	GO:0005515	protein binding	Pdia3	IPI	UniProtKB:Q91X17	Mouse	PMID:28437467
Molecular Function	GO:0005515	protein binding	Pdia3	IPI	PR:O55143	Mouse	PMID:23395171
Molecular Function	GO:0005515	protein binding	Pdia3	IPI	PR:Q3U145	Mouse	PMID:23395171
Molecular Function	GO:0005515	protein binding	Pdia3	IPI	RGD:3686	Rat	PMID:11832422|RGD:632898
Molecular Function	GO:0005515	protein binding	Pdia3	IPI	UniProtKB:Q99JC6	Rat	PMID:17947644|RGD:13792542
Molecular Function	GO:0005515	protein binding	Pdia3	IPI	RGD:2267|RGD:2270	Rat	PMID:18559257|RGD:9999185
Molecular Function	GO:0019153	protein-disulfide reductase (glutathione) activity	Pdia3	IMP		Rat	PMID:12032078|RGD:9999151
Molecular Function	GO:0015035	protein-disulfide reductase activity	PDIA3	IDA		Human	PMID:16677074
Molecular Function	GO:0003723	RNA binding	PDIA3	HDA		Human	PMID:22658674
Cellular Component	GO:0001669	acrosomal vesicle	Pdia3	IDA		Rat	PMID:23317155|RGD:9999140
Cellular Component	GO:0016324	apical plasma membrane	Pdia3	IDA		Rat	PMID:11832422|RGD:632898
Cellular Component	GO:0009986	cell surface	PDIA3	IDA		Human	PMID:19995400
Cellular Component	GO:0009986	cell surface	Pdia3	IDA		Mouse	PMID:19995400
Cellular Component	GO:0009986	cell surface	Pdia3	IDA		Rat	PMID:15862831|RGD:9999173
Cellular Component	GO:0005737	cytoplasm	Pdia3	IDA		Rat	PMID:23317155|RGD:9999140
Cellular Component	GO:0005783	endoplasmic reticulum	PDIA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	PDIA3	IDA		Human	PMID:23826168
Cellular Component	GO:0005783	endoplasmic reticulum	Pdia3	IDA		Mouse	PMID:9493907
Cellular Component	GO:0005783	endoplasmic reticulum	Pdia3	IDA		Rat	PMID:15862831|RGD:9999173
Cellular Component	GO:0070062	extracellular exosome	PDIA3	HDA		Human	PMID:19199708
Cellular Component	GO:0005576	extracellular region	Pdia3	IDA		Rat	PMID:23317155|RGD:9999140
Cellular Component	GO:0005615	extracellular space	PDIA3	IDA		Human	PMID:19995400
Cellular Component	GO:0005615	extracellular space	Pdia3	IDA		Rat	PMID:22201020|RGD:9999164
Cellular Component	GO:0005925	focal adhesion	PDIA3	HDA		Human	PMID:21423176
Cellular Component	GO:0042824	MHC class I peptide loading complex	PDIA3	IDA		Human	PMID:17947644
Cellular Component	GO:0042824	MHC class I peptide loading complex	PDIA3	IDA		Human	PMID:21263072
Cellular Component	GO:0042824	MHC class I peptide loading complex	Pdia3	IDA		Rat	PMID:17947644|RGD:13792542
Cellular Component	GO:0005758	mitochondrial intermembrane space	Pdia3	IDA		Rat	PMID:18559257|RGD:9999185
Cellular Component	GO:0005739	mitochondrion	Pdia3	IDA		Rat	PMID:18559257|RGD:9999185
Cellular Component	GO:0043209	myelin sheath	Pdia3	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005634	nucleus	PDIA3	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	Pdia3	IDA		Rat	PMID:15862831|RGD:9999173
Cellular Component	GO:0005886	plasma membrane	Pdia3	IDA		Rat	PMID:23317155|RGD:9999140
Cellular Component	GO:0005790	smooth endoplasmic reticulum	Pdia3	IDA		Rat	PMID:22665516|RGD:8553430
Cellular Component	GO:0042825	TAP complex	Pdia3	IDA		Rat	PMID:9637924|RGD:9999147
Cellular Component	GO:0061779	Tapasin-ERp57 complex	PDIA3	IPI		Human	PMID:19119025
Biological Process	GO:0098761	cellular response to interleukin-7	Pdia3	IDA		Mouse	PMID:29581031
Biological Process	GO:1904148	cellular response to nonylphenol	Pdia3	IEP		Rat	PMID:19260726|RGD:9999197
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Pdia3	IEP		Rat	PMID:15862831|RGD:9999173
Biological Process	GO:0071305	cellular response to vitamin D	Pdia3	IDA		Rat	PMID:15862831|RGD:9999173
Biological Process	GO:0007623	circadian rhythm	Pdia3	IEP		Rat	PMID:16375900|RGD:9999182
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Pdia3	IMP		Mouse	PMID:15858817
Biological Process	GO:0002502	peptide antigen assembly with MHC class I protein complex	PDIA3	IDA		Human	PMID:17603487
Biological Process	GO:0070527	platelet aggregation	Pdia3	IMP		Mouse	PMID:28576878
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Pdia3	IMP		Mouse	PMID:15858817
Biological Process	GO:1903334	positive regulation of protein folding	Pdia3	IDA		Rat	PMID:16184766|RGD:9999184
Biological Process	GO:1901423	response to benzene	Pdia3	IEP		Rat	PMID:12018992|RGD:9999177
Biological Process	GO:0045471	response to ethanol	Pdia3	IEP		Rat	PMID:22545783|RGD:7495839
Biological Process	GO:0033595	response to genistein	Pdia3	IEP		Rat	PMID:21254785|RGD:5131487
Biological Process	GO:0055093	response to hyperoxia	Pdia3	IEP		Rat	PMID:19411306|RGD:9999157
Biological Process	GO:0001666	response to hypoxia	Pdia3	IEP		Rat	PMID:23315792|RGD:9999167
Biological Process	GO:0002931	response to ischemia	Pdia3	IEP		Rat	PMID:12872233|RGD:1624250
Biological Process	GO:0044321	response to leptin	Pdia3	IEP		Rat	PMID:16375900|RGD:9999182
Biological Process	GO:0031667	response to nutrient levels	Pdia3	IEP		Rat	PMID:16375900|RGD:9999182

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern