Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDK1
  • Mouse genes Pdk1
  • Rat genes Pdk1
  • Zfish genes pdk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Pdk1	IDA		Rat	PMID:12573248|RGD:2307429
Molecular Function	GO:0005524	ATP binding	Pdk1	IDA		Rat	PMID:9405293|RGD:68199
Molecular Function	GO:0042802	identical protein binding	Pdk1	IPI	RGD:69427	Rat	PMID:12573248|RGD:2307429
Molecular Function	GO:0005515	protein binding	PDK1	IPI	UniProtKB:Q16513	Human	PMID:17110931
Molecular Function	GO:0005515	protein binding	PDK1	IPI	UniProtKB:P08559	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	PDK1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PDK1	IPI	UniProtKB:P08559	Human	PMID:7782287
Molecular Function	GO:0005515	protein binding	Pdk1	IPI	RGD:69428	Rat	PMID:12573248|RGD:2307429
Molecular Function	GO:0004672	protein kinase activity	PDK1	IDA		Human	PMID:17683942
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Pdk1	IDA		Rat	PMID:11486000|RGD:8553418
Molecular Function	GO:0044877	protein-containing complex binding	Pdk1	IDA		Rat	PMID:12573248|RGD:2307429
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK1	EXP		Human	PMID:11485553
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK1	IMP		Human	PMID:22195962
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK1	IDA		Human	PMID:7499431
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk1	IDA		Rat	PMID:11486000|RGD:8553418
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk1	IDA		Rat	PMID:12573248|RGD:2307429
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk1	IDA		Rat	PMID:8253790|RGD:68684
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk1	IDA		Rat	PMID:9405293|RGD:68199
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	Pdk1	IDA		Mouse	MGI:MGI:5487511|PMID:22195962
Cellular Component	GO:0005739	mitochondrion	Pdk1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Pdk1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	Pdk1	IDA		Rat	PMID:12573248|RGD:2307429
Biological Process	GO:0008283	cell population proliferation	PDK1	IMP		Human	PMID:18541534
Biological Process	GO:0007166	cell surface receptor signaling pathway	Pdk1	IMP		Rat	PMID:15007074|RGD:1642700
Biological Process	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	PDK1	IMP		Human	PMID:21763680
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	PDK1	IMP		Human	PMID:18541534
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Pdk1	IDA		Rat	PMID:11486000|RGD:8553418
Biological Process	GO:0006468	protein phosphorylation	Pdk1	IDA		Rat	PMID:12573248|RGD:2307429
Biological Process	GO:0006468	protein phosphorylation	Pdk1	IDA		Rat	PMID:9405293|RGD:68199
Biological Process	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate	Pdk1	IMP		Mouse	MGI:MGI:5487511|PMID:22195962
Biological Process	GO:0010906	regulation of glucose metabolic process	PDK1	IMP		Human	PMID:18541534

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern