Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pdk2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PDK2
- Mouse genes Pdk2
- Rat genes Pdk2
- Zfish genes pdk2a,pdk2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	PDK2	IDA		Human	PMID:16401071
Molecular Function	GO:0005524	ATP binding	Pdk2	IMP		Rat	PMID:10698691\|RGD:1582377
Molecular Function	GO:0005524	ATP binding	Pdk2	IDA		Rat	PMID:12573248\|RGD:2307429
Molecular Function	GO:0005524	ATP binding	Pdk2	IDA		Rat	PMID:15312755\|RGD:1582376
Molecular Function	GO:0005524	ATP binding	Pdk2	IDA		Rat	PMID:9405293\|RGD:68199
Molecular Function	GO:0042802	identical protein binding	Pdk2	IPI	RGD:69428	Rat	PMID:12573248\|RGD:2307429
Molecular Function	GO:0005515	protein binding	PDK2	IPI	UniProtKB:P42858	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	PDK2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Pdk2	IPI	UniProtKB:O08908	Mouse	MGI:MGI:3688344\|PMID:15102471
Molecular Function	GO:0005515	protein binding	Pdk2	IPI	RGD:69427	Rat	PMID:12573248\|RGD:2307429
Molecular Function	GO:0042803	protein homodimerization activity	PDK2	IPI	UniProtKB:Q15119	Human	PMID:19833728
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Pdk2	IDA		Rat	PMID:11486000\|RGD:8553418
Molecular Function	GO:0044877	protein-containing complex binding	Pdk2	IDA		Rat	PMID:12573248\|RGD:2307429
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK2	EXP		Human	PMID:11485553
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK2	IDA		Human	PMID:19833728
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IMP		Mouse	MGI:MGI:5428826\|PMID:22360721
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IMP		Rat	PMID:10698691\|RGD:1582377
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IDA		Rat	PMID:11486000\|RGD:8553418
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IDA		Rat	PMID:12573248\|RGD:2307429
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IDA		Rat	PMID:15312755\|RGD:1582376
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk2	IDA		Rat	PMID:9405293\|RGD:68199
Cellular Component	GO:0005829	cytosol	PDK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	Pdk2	IDA		Mouse	MGI:MGI:4888421\|PMID:21190881
Cellular Component	GO:0005739	mitochondrion	PDK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Pdk2	IDA		Mouse	MGI:MGI:4888421\|PMID:21190881
Cellular Component	GO:0005739	mitochondrion	Pdk2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Pdk2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Pdk2	IDA		Rat	PMID:10698691\|RGD:1582377
Cellular Component	GO:0005654	nucleoplasm	PDK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	Pdk2	IDA		Rat	PMID:12573248\|RGD:2307429
Biological Process	GO:0031670	cellular response to nutrient	Pdk2	IMP		Mouse	MGI:MGI:5428826\|PMID:22360721
Biological Process	GO:0034614	cellular response to reactive oxygen species	PDK2	IMP		Human	PMID:21283817
Biological Process	GO:0042593	glucose homeostasis	Pdk2	IMP		Mouse	MGI:MGI:5428826\|PMID:22360721
Biological Process	GO:0008286	insulin receptor signaling pathway	Pdk2	IMP		Mouse	MGI:MGI:5428826\|PMID:22360721
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	PDK2	IMP		Human	PMID:22123926
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Pdk2	IDA		Rat	PMID:11486000\|RGD:8553418
Biological Process	GO:0006468	protein phosphorylation	Pdk2	IMP		Rat	PMID:10698691\|RGD:1582377
Biological Process	GO:0006468	protein phosphorylation	Pdk2	IDA		Rat	PMID:12573248\|RGD:2307429
Biological Process	GO:0006468	protein phosphorylation	Pdk2	IDA		Rat	PMID:15312755\|RGD:1582376
Biological Process	GO:0006468	protein phosphorylation	Pdk2	IDA		Rat	PMID:9405293\|RGD:68199
Biological Process	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate	Pdk2	IMP		Mouse	MGI:MGI:5428826\|PMID:22360721
Biological Process	GO:0050848	regulation of calcium-mediated signaling	Pdk2	IMP	MGI:MGI:5496378	Mouse	PMID:23357539
Biological Process	GO:0010565	regulation of cellular ketone metabolic process	Pdk2	IMP		Mouse	MGI:MGI:5428826\|PMID:22360721
Biological Process	GO:0006111	regulation of gluconeogenesis	Pdk2	IMP		Mouse	MGI:MGI:5428826\|PMID:22360721
Biological Process	GO:0010906	regulation of glucose metabolic process	Pdk2	IMP		Mouse	MGI:MGI:5428826\|PMID:22360721
Biological Process	GO:0006885	regulation of pH	Pdk2	IMP		Mouse	MGI:MGI:5428826\|PMID:22360721

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.