Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDK4
  • Mouse genes Pdk4
  • Rat genes Pdk4
  • Zfish genes pdk4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdk4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	PDK4	IDA		Human	PMID:18658136
Molecular Function	GO:0005524	ATP binding	Pdk4	IMP		Rat	PMID:10698691|RGD:1582377
Molecular Function	GO:0005524	ATP binding	Pdk4	IDA		Rat	PMID:15312755|RGD:1582376
Molecular Function	GO:0005524	ATP binding	Pdk4	IDA		Rat	PMID:9405293|RGD:68199
Molecular Function	GO:0005515	protein binding	PDK4	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0004672	protein kinase activity	PDK4	IDA		Human	PMID:18658136
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK4	EXP		Human	PMID:11485553
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk4	IMP		Rat	PMID:10698691|RGD:1582377
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk4	IDA		Rat	PMID:11486000|RGD:8553418
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk4	IDA		Rat	PMID:12435272|RGD:729541
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk4	IDA		Rat	PMID:15312755|RGD:1582376
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Pdk4	IDA		Rat	PMID:9405293|RGD:68199
Cellular Component	GO:0005743	mitochondrial inner membrane	Pdk4	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005739	mitochondrion	Pdk4	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Pdk4	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Pdk4	IDA		Rat	PMID:10698691|RGD:1582377
Biological Process	GO:0071398	cellular response to fatty acid	PDK4	IMP		Human	PMID:20715114
Biological Process	GO:0009267	cellular response to starvation	PDK4	IDA		Human	PMID:14966024
Biological Process	GO:0042593	glucose homeostasis	Pdk4	IMP		Mouse	MGI:MGI:3692363|PMID:16606348
Biological Process	GO:0008286	insulin receptor signaling pathway	PDK4	IMP		Human	PMID:21852536
Biological Process	GO:0008286	insulin receptor signaling pathway	Pdk4	IMP		Mouse	MGI:MGI:4420379|PMID:19627255
Biological Process	GO:2000811	negative regulation of anoikis	PDK4	IMP		Human	PMID:21852536
Biological Process	GO:0006468	protein phosphorylation	Pdk4	IMP		Rat	PMID:10698691|RGD:1582377
Biological Process	GO:0006468	protein phosphorylation	Pdk4	IDA		Rat	PMID:15312755|RGD:1582376
Biological Process	GO:0006468	protein phosphorylation	Pdk4	IDA		Rat	PMID:9405293|RGD:68199
Biological Process	GO:0072593	reactive oxygen species metabolic process	PDK4	IMP		Human	PMID:21852536
Biological Process	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate	PDK4	IMP		Human	PMID:21852536
Biological Process	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate	Pdk4	IMP		Mouse	MGI:MGI:3692363|PMID:16606348
Biological Process	GO:0045124	regulation of bone resorption	Pdk4	IMP		Mouse	MGI:MGI:5303050|PMID:21803180
Biological Process	GO:0010565	regulation of cellular ketone metabolic process	Pdk4	IMP		Mouse	MGI:MGI:3692363|PMID:16606348
Biological Process	GO:0042304	regulation of fatty acid biosynthetic process	PDK4	IMP		Human	PMID:21852536
Biological Process	GO:0042304	regulation of fatty acid biosynthetic process	Pdk4	IMP		Mouse	MGI:MGI:4420379|PMID:19627255
Biological Process	GO:0046320	regulation of fatty acid oxidation	Pdk4	IMP		Mouse	MGI:MGI:3692363|PMID:16606348
Biological Process	GO:0010906	regulation of glucose metabolic process	PDK4	IMP		Human	PMID:21852536
Biological Process	GO:0010906	regulation of glucose metabolic process	Pdk4	IMP		Mouse	MGI:MGI:3692363|PMID:16606348
Biological Process	GO:0006885	regulation of pH	Pdk4	IMP		Mouse	MGI:MGI:5428826|PMID:22360721
Biological Process	GO:0042594	response to starvation	Pdk4	IMP		Mouse	MGI:MGI:3692363|PMID:16606348

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern