Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDPN
  • Mouse genes Pdpn
  • Rat genes Pdpn
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdpn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019956	chemokine binding	PDPN	IPI	UniProtKB:O00585	Human	PMID:14978162
Molecular Function	GO:0005515	protein binding	PDPN	IPI	UniProtKB:P15311|UniProtKB:P26038	Human	PMID:17046996
Molecular Function	GO:0005515	protein binding	PDPN	IPI	UniProtKB:Q9P126	Human	PMID:17616532
Molecular Function	GO:0005515	protein binding	PDPN	IPI	UniProtKB:Q9P126	Human	PMID:18215137
Molecular Function	GO:0005515	protein binding	PDPN	IPI	UniProtKB:P21926	Human	PMID:18541721
Molecular Function	GO:0005515	protein binding	PDPN	IPI	UniProtKB:O00214	Human	PMID:19268462
Molecular Function	GO:0005515	protein binding	PDPN	IPI	UniProtKB:P16070	Human	PMID:20962267
Molecular Function	GO:0005515	protein binding	PDPN	IPI	UniProtKB:Q9P126-1	Human	PMID:25458834
Molecular Function	GO:0005515	protein binding	PDPN	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pdpn	IPI	UniProtKB:Q9P126	Mouse	MGI:MGI:3722196|PMID:17616532
Molecular Function	GO:0051087	protein-folding chaperone binding	PDPN	IPI	UniProtKB:P38646	Human	PMID:23541579
Molecular Function	GO:0005102	signaling receptor binding	PDPN	IDA		Human	PMID:18215137
Cellular Component	GO:0016324	apical plasma membrane	PDPN	IDA		Human	PMID:20962267
Cellular Component	GO:0016324	apical plasma membrane	Pdpn	IDA		Rat	PMID:7851650|RGD:61612
Cellular Component	GO:0016323	basolateral plasma membrane	PDPN	IDA		Human	PMID:14978162
Cellular Component	GO:0030054	cell junction	PDPN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0042995	cell projection	PDPN	IDA		Human	PMID:20962267
Cellular Component	GO:0031410	cytoplasmic vesicle	PDPN	IDA		Human	PMID:17046996
Cellular Component	GO:0005829	cytosol	PDPN	IDA		Human	PMID:24275092
Cellular Component	GO:0009897	external side of plasma membrane	Pdpn	IDA		Mouse	PMID:23180825
Cellular Component	GO:0030175	filopodium	Pdpn	IDA		Mouse	MGI:MGI:1351508|PMID:10574709
Cellular Component	GO:0031527	filopodium membrane	PDPN	IDA		Human	PMID:17046996
Cellular Component	GO:0030027	lamellipodium	Pdpn	IDA		Mouse	MGI:MGI:1351508|PMID:10574709
Cellular Component	GO:0031258	lamellipodium membrane	PDPN	IDA		Human	PMID:20962267
Cellular Component	GO:0061851	leading edge of lamellipodium	PDPN	IDA		Human	PMID:17046996
Cellular Component	GO:0016020	membrane	PDPN	IDA		Human	PMID:24275092
Cellular Component	GO:0045121	membrane raft	PDPN	IDA		Human	PMID:21376833
Cellular Component	GO:0031528	microvillus membrane	PDPN	IDA		Human	PMID:17046996
Cellular Component	GO:0005739	mitochondrion	PDPN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PDPN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PDPN	IDA		Human	PMID:17046996
Cellular Component	GO:0005886	plasma membrane	PDPN	IDA		Human	PMID:18215137
Cellular Component	GO:0005886	plasma membrane	PDPN	IDA		Human	PMID:20962267
Cellular Component	GO:0005886	plasma membrane	Pdpn	IDA		Mouse	MGI:MGI:5614157|PMID:25341788
Cellular Component	GO:0005886	plasma membrane	Pdpn	IDA		Mouse	PMID:12853470
Cellular Component	GO:0005886	plasma membrane	Pdpn	IDA		Mouse	PMID:9632596
Cellular Component	GO:0005886	plasma membrane	Pdpn	IDA		Rat	PMID:15849211|RGD:2292242
Cellular Component	GO:0001726	ruffle	Pdpn	IDA		Mouse	MGI:MGI:1351508|PMID:10574709
Cellular Component	GO:0032587	ruffle membrane	PDPN	IDA		Human	PMID:17046996
Cellular Component	GO:0097197	tetraspanin-enriched microdomain	PDPN	IDA		Human	PMID:18541721
Biological Process	GO:0070252	actin-mediated cell contraction	Pdpn	IDA		Mouse	MGI:MGI:5614157|PMID:25341788
Biological Process	GO:0007155	cell adhesion	Pdpn	IDA		Rat	PMID:12853470|RGD:8553558
Biological Process	GO:0016477	cell migration	Pdpn	IMP		Mouse	MGI:MGI:1351508|PMID:10574709
Biological Process	GO:0008283	cell population proliferation	Pdpn	IMP	MGI:MGI:2657021	Mouse	PMID:16869965
Biological Process	GO:0098609	cell-cell adhesion	Pdpn	IMP	MGI:MGI:2657021	Mouse	PMID:16869965
Biological Process	GO:0006954	inflammatory response	Pdpn	IEP		Rat	PMID:15849211|RGD:2292242
Biological Process	GO:0048286	lung alveolus development	Pdpn	IMP	MGI:MGI:2657021	Mouse	PMID:16869965
Biological Process	GO:0030324	lung development	Pdpn	IMP	MGI:MGI:2657021	Mouse	PMID:12654292
Biological Process	GO:0030324	lung development	Pdpn	IEP		Rat	PMID:8652186|RGD:2292371
Biological Process	GO:0048535	lymph node development	Pdpn	IMP		Mouse	MGI:MGI:5644359|PMID:25347465
Biological Process	GO:0001946	lymphangiogenesis	Pdpn	IMP	MGI:MGI:2657021	Mouse	PMID:12853470
Biological Process	GO:0060838	lymphatic endothelial cell fate commitment	Pdpn	IMP		Mouse	MGI:MGI:4453945|PMID:20110424
Biological Process	GO:0043066	negative regulation of apoptotic process	Pdpn	IMP		Mouse	MGI:MGI:5644359|PMID:25347465
Biological Process	GO:0008285	negative regulation of cell population proliferation	Pdpn	IMP		Mouse	MGI:MGI:5644359|PMID:25347465
Biological Process	GO:0007399	nervous system development	Pdpn	IEP		Rat	PMID:8652186|RGD:2292371
Biological Process	GO:0030335	positive regulation of cell migration	PDPN	IMP		Human	PMID:21376833
Biological Process	GO:0030335	positive regulation of cell migration	Pdpn	IDA		Rat	PMID:12853470|RGD:8553558
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	PDPN	IMP		Human	PMID:17046996
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	PDPN	IMP		Human	PMID:21376833
Biological Process	GO:0090091	positive regulation of extracellular matrix disassembly	PDPN	IDA		Human	PMID:25486435
Biological Process	GO:0010572	positive regulation of platelet activation	Pdpn	IMP		Rat	PMID:16979138|RGD:2292241
Biological Process	GO:1901731	positive regulation of platelet aggregation	PDPN	IDA		Human	PMID:17222411
Biological Process	GO:1901731	positive regulation of platelet aggregation	PDPN	IMP		Human	PMID:17616532
Biological Process	GO:1901731	positive regulation of platelet aggregation	PDPN	IMP		Human	PMID:18541721
Biological Process	GO:1901731	positive regulation of platelet aggregation	PDPN	IDA		Human	PMID:20110424
Biological Process	GO:1901731	positive regulation of platelet aggregation	Pdpn	IDA		Mouse	MGI:MGI:3722196|PMID:17616532
Biological Process	GO:1901731	positive regulation of platelet aggregation	Pdpn	IMP		Mouse	MGI:MGI:4453945|PMID:20110424
Biological Process	GO:0006693	prostaglandin metabolic process	Pdpn	IMP	MGI:MGI:2657021	Mouse	PMID:16869965
Biological Process	GO:0030155	regulation of cell adhesion	Pdpn	IMP		Mouse	MGI:MGI:5644359|PMID:25347465
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	Pdpn	IMP	MGI:MGI:2657021	Mouse	PMID:16869965
Biological Process	GO:2000392	regulation of lamellipodium morphogenesis	PDPN	IMP		Human	PMID:20962267
Biological Process	GO:1904328	regulation of myofibroblast contraction	Pdpn	IMP		Mouse	MGI:MGI:5644359|PMID:25347465
Biological Process	GO:1900024	regulation of substrate adhesion-dependent cell spreading	Pdpn	IMP		Mouse	MGI:MGI:5644359|PMID:25347465
Biological Process	GO:0055093	response to hyperoxia	Pdpn	IEP		Rat	PMID:12922978|RGD:1302251
Biological Process	GO:0007266	Rho protein signal transduction	PDPN	IMP		Human	PMID:25486435
Biological Process	GO:0007165	signal transduction	Pdpn	IMP	MGI:MGI:2657021	Mouse	PMID:16869965
Biological Process	GO:0035239	tube morphogenesis	Pdpn	IDA		Rat	PMID:12853470|RGD:8553558
Biological Process	GO:0044319	wound healing, spreading of cells	PDPN	IMP		Human	PMID:20962267

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern