Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDX1
  • Mouse genes Pdx1
  • Rat genes Pdx1
  • Zfish genes pdx1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Pdx1	IDA		Mouse	PMID:19651901
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Pdx1	IDA		Mouse	PMID:15486225
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Pdx1	IMP		Rat	PMID:15151993|RGD:1601590
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Pdx1	IDA		Rat	PMID:10094480|RGD:1598709
Molecular Function	GO:1990841	promoter-specific chromatin binding	Pdx1	IDA		Rat	PMID:19380737|RGD:2311163
Molecular Function	GO:0005515	protein binding	Pdx1	IPI	UniProtKB:P13405	Mouse	MGI:MGI:4949030|PMID:21399612
Molecular Function	GO:0005515	protein binding	Pdx1	IPI	UniProtKB:Q6ZWS8	Mouse	MGI:MGI:5512841|PMID:17126328
Molecular Function	GO:0005515	protein binding	Pdx1	IPI	PR:Q60954-1	Mouse	PMID:17056599
Molecular Function	GO:0005515	protein binding	Pdx1	IPI	PR:Q6ZWS8	Mouse	PMID:15121856
Molecular Function	GO:0005515	protein binding	Pdx1	IPI	RGD:1348463	Rat	PMID:15001545|RGD:2311191
Molecular Function	GO:0005515	protein binding	Pdx1	IPI	RGD:621110	Rat	PMID:15885879|RGD:2311184
Molecular Function	GO:0005515	protein binding	Pdx1	IPI	UniProtKB:Q9WTV5	Rat	PMID:15885879|RGD:2311184
Molecular Function	GO:0044877	protein-containing complex binding	Pdx1	IPI	RGD:3258	Rat	PMID:10094480|RGD:1598709
Molecular Function	GO:0044877	protein-containing complex binding	Pdx1	IDA		Rat	PMID:11756538|RGD:2311193
Molecular Function	GO:0044877	protein-containing complex binding	Pdx1	IDA		Rat	PMID:15650027|RGD:2311185
Molecular Function	GO:0044877	protein-containing complex binding	Pdx1	IDA		Rat	PMID:8524276|RGD:2311198
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pdx1	IDA		Mouse	MGI:MGI:5572886|PMID:14704343
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pdx1	IDA		Mouse	PMID:15486225
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pdx1	IDA		Mouse	PMID:17056599
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pdx1	IDA		Mouse	PMID:12368292
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Pdx1	IDA		Mouse	PMID:12972592
Molecular Function	GO:0043565	sequence-specific DNA binding	Pdx1	IDA		Mouse	PMID:14701942
Molecular Function	GO:0043565	sequence-specific DNA binding	Pdx1	IDA		Rat	PMID:10094480|RGD:1598709
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PDX1	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Pdx1	IDA		Rat	PMID:15609091|RGD:2311186
Cellular Component	GO:0005737	cytoplasm	Pdx1	IDA		Rat	PMID:16887799|RGD:2311183
Cellular Component	GO:0005622	intracellular anatomical structure	Pdx1	IDA		Mouse	PMID:15793245
Cellular Component	GO:0005622	intracellular anatomical structure	Pdx1	IDA		Mouse	PMID:10868931
Cellular Component	GO:0016607	nuclear speck	Pdx1	IDA		Mouse	PMID:15121856
Cellular Component	GO:0005654	nucleoplasm	PDX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Pdx1	IDA		Mouse	PMID:18155690
Cellular Component	GO:0005634	nucleus	Pdx1	IDA		Mouse	PMID:17928203
Cellular Component	GO:0005634	nucleus	Pdx1	IDA		Mouse	PMID:14702043
Cellular Component	GO:0005634	nucleus	Pdx1	IDA		Mouse	PMID:11287626
Cellular Component	GO:0005634	nucleus	Pdx1	IDA		Mouse	PMID:12488434
Cellular Component	GO:0005634	nucleus	Pdx1	IDA		Mouse	PMID:15486225
Cellular Component	GO:0005634	nucleus	Pdx1	IDA		Mouse	PMID:15888377
Cellular Component	GO:0005634	nucleus	Pdx1	IDA		Rat	PMID:10094480|RGD:1598709
Cellular Component	GO:0005634	nucleus	Pdx1	IDA		Rat	PMID:17235568|RGD:2311225
Biological Process	GO:0031100	animal organ regeneration	Pdx1	IEP		Rat	PMID:17690043|RGD:2311227
Biological Process	GO:0030154	cell differentiation	Pdx1	IMP		Rat	PMID:11309388|RGD:2311194
Biological Process	GO:0008283	cell population proliferation	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:18155690
Biological Process	GO:0007417	central nervous system development	Pdx1	IEP		Rat	PMID:10751390|RGD:2311200
Biological Process	GO:0071907	determination of digestive tract left/right asymmetry	pdx1	IMP	ZFIN:ZDB-MRPHLNO-080814-1	Zfish	PMID:11477692
Biological Process	GO:0071910	determination of liver left/right asymmetry	pdx1	IMP	ZFIN:ZDB-MRPHLNO-080814-1	Zfish	PMID:11477692
Biological Process	GO:0035469	determination of pancreatic left/right asymmetry	pdx1	IMP	ZFIN:ZDB-MRPHLNO-080814-1	Zfish	PMID:11477692
Biological Process	GO:0048565	digestive tract development	Pdx1	IMP	MGI:MGI:2388676	Mouse	PMID:19619492
Biological Process	GO:0006351	DNA-templated transcription	Pdx1	IMP		Rat	PMID:15151993|RGD:1601590
Biological Process	GO:0031018	endocrine pancreas development	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:18155690
Biological Process	GO:0031018	endocrine pancreas development	pdx1	IMP	ZFIN:ZDB-MRPHLNO-080814-1	Zfish	PMID:26963759
Biological Process	GO:0031018	endocrine pancreas development	pdx1	IMP	ZFIN:ZDB-CRISPR-160729-20	Zfish	PMID:26963759
Biological Process	GO:0031018	endocrine pancreas development	pdx1	IMP	ZFIN:ZDB-GENO-160129-10	Zfish	PMID:26384018
Biological Process	GO:0031018	endocrine pancreas development	pdx1	IMP	ZFIN:ZDB-MRPHLNO-080814-1	Zfish	PMID:22034951
Biological Process	GO:0031018	endocrine pancreas development	pdx1	IMP	ZFIN:ZDB-MRPHLNO-080814-1	Zfish	PMID:20965191
Biological Process	GO:0031018	endocrine pancreas development	pdx1	IGI	ZFIN:ZDB-MRPHLNO-080814-1,ZFIN:ZDB-MRPHLNO-111028-2	Zfish	PMID:22034951
Biological Process	GO:0035883	enteroendocrine cell differentiation	Pdx1	IMP	MGI:MGI:2181362	Mouse	PMID:16418487
Biological Process	GO:0050673	epithelial cell proliferation	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:18155690
Biological Process	GO:0031017	exocrine pancreas development	Pdx1	IMP	MGI:MGI:2388676	Mouse	PMID:16126192
Biological Process	GO:0042593	glucose homeostasis	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:18155690
Biological Process	GO:0042593	glucose homeostasis	Pdx1	IGI	MGI:MGI:1343085	Mouse	PMID:20811152
Biological Process	GO:0042593	glucose homeostasis	Pdx1	IMP		Rat	PMID:11158595|RGD:2311197
Biological Process	GO:0042593	glucose homeostasis	pdx1	IMP	ZFIN:ZDB-MRPHLNO-080814-1	Zfish	PMID:26963759
Biological Process	GO:0010255	glucose mediated signaling pathway	Pdx1	IDA		Rat	PMID:21108535|RGD:8553608
Biological Process	GO:0006006	glucose metabolic process	Pdx1	IDA		Mouse	PMID:12904469
Biological Process	GO:0030073	insulin secretion	PDX1	IDA		Human	PMID:17941991
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:20811152
Biological Process	GO:0001889	liver development	Pdx1	IMP	MGI:MGI:2388676	Mouse	PMID:19619492
Biological Process	GO:0016331	morphogenesis of embryonic epithelium	Pdx1	IMP	MGI:MGI:2152755	Mouse	PMID:8625829
Biological Process	GO:0008285	negative regulation of cell population proliferation	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:18155690
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Pdx1	IMP		Rat	PMID:17641871|RGD:2311173
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:20811152
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:18155690
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Pdx1	IDA		Mouse	PMID:17056599
Biological Process	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:20811152
Biological Process	GO:0007263	nitric oxide mediated signal transduction	PDX1	IDA		Human	PMID:17941991
Biological Process	GO:0031016	pancreas development	Pdx1	IMP	MGI:MGI:2181362	Mouse	PMID:16418487
Biological Process	GO:0031016	pancreas development	Pdx1	IMP	MGI:MGI:2152755	Mouse	PMID:8625829
Biological Process	GO:0031016	pancreas development	Pdx1	IEP		Rat	PMID:18778483|RGD:2311165
Biological Process	GO:0031016	pancreas development	pdx1	IMP	ZFIN:ZDB-MRPHLNO-080814-1	Zfish	PMID:11477692
Biological Process	GO:0008284	positive regulation of cell population proliferation	Pdx1	IMP		Rat	PMID:11158595|RGD:2311197
Biological Process	GO:0043388	positive regulation of DNA binding	Pdx1	IMP		Rat	PMID:11181516|RGD:2311195
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pdx1	IDA		Mouse	PMID:12368292
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pdx1	IMP		Rat	PMID:18253862|RGD:2311168
Biological Process	GO:0032024	positive regulation of insulin secretion	Pdx1	IDA		Mouse	MGI:MGI:2388494|PMID:12219087
Biological Process	GO:0032024	positive regulation of insulin secretion	Pdx1	IMP		Rat	PMID:18439098|RGD:2306975
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Pdx1	IMP		Mouse	PMID:22253604
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pdx1	IDA		Mouse	MGI:MGI:5574299|PMID:19799567
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pdx1	IDA		Mouse	PMID:15486225
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pdx1	IDA		Mouse	PMID:14701942
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pdx1	IDA		Rat	PMID:10094480|RGD:1598709
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pdx1	IMP		Rat	PMID:21108535|RGD:8553608
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:18155690
Biological Process	GO:0048793	pronephros development	pdx1	IMP	ZFIN:ZDB-GENO-221018-3	Zfish	PMID:35100334
Biological Process	GO:0048793	pronephros development	pdx1	IMP	ZFIN:ZDB-GENO-221018-1	Zfish	PMID:35100334
Biological Process	GO:0048793	pronephros development	pdx1	IMP	ZFIN:ZDB-MRPHLNO-080814-1	Zfish	PMID:35100334
Biological Process	GO:0042127	regulation of cell population proliferation	Pdx1	IDA		Mouse	PMID:12488434
Biological Process	GO:0010468	regulation of gene expression	Pdx1	IMP		Rat	PMID:10802714|RGD:10047145
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Pdx1	IDA		Mouse	PMID:14701942
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Pdx1	IMP		Mouse	PMID:12972592
Biological Process	GO:0043279	response to alkaloid	Pdx1	IEP		Rat	PMID:15448089|RGD:2311187
Biological Process	GO:0010157	response to chlorate	Pdx1	IEP		Rat	PMID:17221210|RGD:2308896
Biological Process	GO:0034097	response to cytokine	Pdx1	IEP		Rat	PMID:16948396|RGD:2298711
Biological Process	GO:0070542	response to fatty acid	Pdx1	IEP		Rat	PMID:17181874|RGD:2311176
Biological Process	GO:0051384	response to glucocorticoid	Pdx1	IEP		Rat	PMID:15331541|RGD:2311188
Biological Process	GO:0009749	response to glucose	Pdx1	IMP		Rat	PMID:15148392|RGD:2311189
Biological Process	GO:0009749	response to glucose	Pdx1	IEP		Rat	PMID:18230696|RGD:2311169
Biological Process	GO:0010040	response to iron(II) ion	Pdx1	IEP		Rat	PMID:16081762|RGD:1600248
Biological Process	GO:0043201	response to leucine	Pdx1	IEP		Rat	PMID:19438972|RGD:2311161
Biological Process	GO:0033993	response to lipid	Pdx1	IEP		Rat	PMID:17991758|RGD:2311170
Biological Process	GO:0035094	response to nicotine	Pdx1	IEP		Rat	PMID:18687784|RGD:2311166
Biological Process	GO:0031667	response to nutrient levels	Pdx1	IEP		Rat	PMID:17882398|RGD:2311172
Biological Process	GO:0014070	response to organic cyclic compound	Pdx1	IEP		Rat	PMID:19438972|RGD:2311161
Biological Process	GO:0033273	response to vitamin	Pdx1	IEP		Rat	PMID:11833042|RGD:2311192
Biological Process	GO:0009611	response to wounding	Pdx1	IEP		Rat	PMID:17583748|RGD:2311174
Biological Process	GO:0009410	response to xenobiotic stimulus	Pdx1	IEP		Rat	PMID:17991720|RGD:2311171
Biological Process	GO:0007224	smoothened signaling pathway	Pdx1	IMP		Rat	PMID:11181516|RGD:2311195
Biological Process	GO:0048863	stem cell differentiation	Pdx1	IMP		Rat	PMID:18253862|RGD:2311168
Biological Process	GO:0048863	stem cell differentiation	Pdx1	IEP		Rat	PMID:19382247|RGD:2311162
Biological Process	GO:0006366	transcription by RNA polymerase II	Pdx1	IMP		Rat	PMID:15151993|RGD:1601590
Biological Process	GO:0060290	transdifferentiation	Pdx1	IEP		Rat	PMID:10952464|RGD:2311199
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:20811152
Biological Process	GO:0003309	type B pancreatic cell differentiation	PDX1	IDA		Human	PMID:12124776
Biological Process	GO:0003309	type B pancreatic cell differentiation	PDX1	IDA		Human	PMID:24567802
Biological Process	GO:0003309	type B pancreatic cell differentiation	Pdx1	IMP	MGI:MGI:2181362	Mouse	PMID:16418487
Biological Process	GO:0003309	type B pancreatic cell differentiation	Pdx1	IMP		Rat	PMID:21108535|RGD:8553608
Biological Process	GO:0044342	type B pancreatic cell proliferation	Pdx1	IMP	MGI:MGI:2181360	Mouse	PMID:18155690

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern