Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PECAM1
  • Mouse genes Pecam1
  • Rat genes Pecam1
  • Zfish genes pecam1a,pecam1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pecam1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q06124	Human	PMID:10704309
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P12931	Human	PMID:10801826
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P14923	Human	PMID:10801826
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q06124	Human	PMID:15985432
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q8N6Q3	Human	PMID:17580308
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P30411	Human	PMID:18672896
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P50148	Human	PMID:18672896
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:O95832	Human	PMID:26607202
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q16625	Human	PMID:26607202
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q96AP7	Human	PMID:26607202
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P09382	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:A0A024RCP2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:I6L9F6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:O15273	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:O15287	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:O60506-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:O75175	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:O75874	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P09382	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P12757	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P15923-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P17024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P19544-6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P26651	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P46977	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P49184	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P54819	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P61513	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P61966-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q08AE8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q08AM6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q0VD86	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q12824	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q12888	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q13405	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q13428-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q14728	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q14847-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q16549	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q4G1C9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q5JSH3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q5T1C6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q5VYS8-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q6DHV7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q6IAA8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q6NXG1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q6XD76	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q6ZQX7-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q6ZSB9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q6ZU52	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q7Z403	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q7Z614-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q8IUW3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q8N302-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q8NBT0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q8NC51	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q8NCS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q8TAB5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q8TBJ4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q8WUY3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q96BD6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q96E93	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q96G97-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q96GL9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q96HB5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q96I25	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q96JJ7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q96LI6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q96PV4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q99504	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q99619	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q99944	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9BQ29	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9GZQ6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9H270	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9H7C4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9HB63	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9NS73-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9NX09	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9P286	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9UJD0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9UMX3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9UQM7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q9Y3D0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P12931	Human	PMID:9162084
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q06124	Human	PMID:9312087
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:P29350	Human	PMID:9774457
Molecular Function	GO:0005515	protein binding	PECAM1	IPI	UniProtKB:Q06124	Human	PMID:9774457
Molecular Function	GO:0005515	protein binding	Pecam1	IPI	PR:P42227	Mouse	PMID:11254359
Molecular Function	GO:0005515	protein binding	Pecam1	IPI	MGI:MGI:103036	Mouse	PMID:11254359
Molecular Function	GO:0005515	protein binding	Pecam1	IPI	PR:Q9QZE2	Mouse	PMID:10562326
Molecular Function	GO:0005515	protein binding	Pecam1	IPI	PR:Q9ESD7	Mouse	PMID:20724702
Molecular Function	GO:0042803	protein homodimerization activity	PECAM1	IDA		Human	PMID:26702061
Molecular Function	GO:0042803	protein homodimerization activity	PECAM1	IDA		Human	PMID:27958302
Molecular Function	GO:0019903	protein phosphatase binding	Pecam1	IPI	RGD:3447	Rat	PMID:9388260|RGD:2311659
Cellular Component	GO:0071944	cell periphery	Pecam1	IDA		Mouse	PMID:21464233
Cellular Component	GO:0009986	cell surface	Pecam1	IDA		Rat	PMID:18466611|RGD:2311658
Cellular Component	GO:0009986	cell surface	Pecam1	IDA		Rat	PMID:22592748|RGD:6483494
Cellular Component	GO:0044291	cell-cell contact zone	Pecam1	IDA		Mouse	PMID:20724702
Cellular Component	GO:0005911	cell-cell junction	PECAM1	IDA		Human	PMID:15572031
Cellular Component	GO:0005737	cytoplasm	Pecam1	IDA		Mouse	PMID:20724702
Cellular Component	GO:0009897	external side of plasma membrane	Pecam1	IDA		Mouse	MGI:MGI:4820887|PMID:20620994
Cellular Component	GO:0009897	external side of plasma membrane	Pecam1	IDA		Mouse	PMID:19299737
Cellular Component	GO:0009897	external side of plasma membrane	Pecam1	IDA		Mouse	PMID:24009720
Cellular Component	GO:0009897	external side of plasma membrane	Pecam1	IDA		Mouse	PMID:16455951
Cellular Component	GO:0009897	external side of plasma membrane	Pecam1	IDA		Mouse	PMID:21708977
Cellular Component	GO:0070062	extracellular exosome	PECAM1	HDA		Human	PMID:20458337
Cellular Component	GO:0005615	extracellular space	PECAM1	IDA		Human	PMID:9290466
Cellular Component	GO:0016020	membrane	Pecam1	IDA		Mouse	PMID:16691571
Cellular Component	GO:0045121	membrane raft	Pecam1	IDA		Mouse	PMID:12890700
Cellular Component	GO:0005886	plasma membrane	PECAM1	IDA		Human	PMID:17464107
Cellular Component	GO:0005886	plasma membrane	Pecam1	IDA		Mouse	PMID:16251442
Cellular Component	GO:0005886	plasma membrane	Pecam1	IDA		Mouse	PMID:12736726
Cellular Component	GO:0032991	protein-containing complex	PECAM1	IDA		Human	PMID:26607202
Cellular Component	GO:0001726	ruffle	Pecam1	IDA		Rat	PMID:9148965|RGD:11541088
Cellular Component	GO:0030485	smooth muscle contractile fiber	Pecam1	IDA		Mouse	PMID:18332105
Biological Process	GO:0001525	angiogenesis	Pecam1	IMP	MGI:MGI:2677448	Mouse	PMID:17563397
Biological Process	GO:0070830	bicellular tight junction assembly	PECAM1	IMP		Human	PMID:26607202
Biological Process	GO:0007155	cell adhesion	Pecam1	IDA		Mouse	PMID:20724702
Biological Process	GO:0098609	cell-cell adhesion	PECAM1	IDA		Human	PMID:15572031
Biological Process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	PECAM1	IMP		Human	PMID:17580308
Biological Process	GO:0071407	cellular response to organic cyclic compound	Pecam1	IEP		Rat	PMID:21414398|RGD:11541081
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Pecam1	IEP		Rat	PMID:18466611|RGD:2311658
Biological Process	GO:0071346	cellular response to type II interferon	Pecam1	IEP		Rat	PMID:18466611|RGD:2311658
Biological Process	GO:0050904	diapedesis	PECAM1	IDA		Human	PMID:19342684
Biological Process	GO:0043542	endothelial cell migration	Pecam1	IMP	MGI:MGI:2677448	Mouse	PMID:17563397
Biological Process	GO:0001886	endothelial cell morphogenesis	Pecam1	IMP	MGI:MGI:2677448	Mouse	PMID:17563397
Biological Process	GO:0090673	endothelial cell-matrix adhesion	Pecam1	IMP	MGI:MGI:2677448	Mouse	PMID:17563397
Biological Process	GO:0061028	establishment of endothelial barrier	PECAM1	IMP		Human	PMID:7589563
Biological Process	GO:0072011	glomerular endothelium development	PECAM1	IEP		Human	PMID:17464107
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	PECAM1	IMP		Human	PMID:27958302
Biological Process	GO:0007159	leukocyte cell-cell adhesion	PECAM1	IMP		Human	PMID:17580308
Biological Process	GO:0035696	monocyte extravasation	PECAM1	IMP		Human	PMID:11078691
Biological Process	GO:0030837	negative regulation of actin filament polymerization	Pecam1	IDA		Rat	PMID:17662049|RGD:7240703
Biological Process	GO:0034260	negative regulation of GTPase activity	Pecam1	IDA		Rat	PMID:17662049|RGD:7240703
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Pecam1	IDA		Rat	PMID:17662049|RGD:7240703
Biological Process	GO:0072672	neutrophil extravasation	PECAM1	IMP		Human	PMID:17580308
Biological Process	GO:0072672	neutrophil extravasation	PECAM1	IMP		Human	PMID:22266279
Biological Process	GO:0006909	phagocytosis	PECAM1	IDA		Human	PMID:12110892
Biological Process	GO:0030335	positive regulation of cell migration	PECAM1	IDA		Human	PMID:15572031
Biological Process	GO:0002693	positive regulation of cellular extravasation	Pecam1	IMP		Rat	PMID:10861081|RGD:11541092
Biological Process	GO:0002687	positive regulation of leukocyte migration	Pecam1	IMP		Rat	PMID:8248808|RGD:2311661
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PECAM1	IMP		Human	PMID:26706435
Biological Process	GO:0150107	positive regulation of protein localization to cell-cell junction	PECAM1	IDA		Human	PMID:26706435
Biological Process	GO:0001934	positive regulation of protein phosphorylation	PECAM1	IMP		Human	PMID:15985432
Biological Process	GO:0001934	positive regulation of protein phosphorylation	PECAM1	IMP		Human	PMID:26706435
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Pecam1	IDA		Mouse	PMID:11254359
Biological Process	GO:0030334	regulation of cell migration	Pecam1	IMP	MGI:MGI:2677448	Mouse	PMID:12890700
Biological Process	GO:0007266	Rho protein signal transduction	Pecam1	IMP	MGI:MGI:2677448	Mouse	PMID:12890700
Biological Process	GO:0042060	wound healing	Pecam1	IMP	MGI:MGI:2677448	Mouse	PMID:12890700

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern