Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PENK
  • Mouse genes Penk
  • Rat genes Penk
  • Zfish genes penka,penkb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Penk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001515	opioid peptide activity	Penk	IDA		Mouse	MGI:MGI:7260092|PMID:35201898
Molecular Function	GO:0001515	opioid peptide activity	Penk	IDA		Mouse	MGI:MGI:7260101|PMID:6933569
Molecular Function	GO:0031628	opioid receptor binding	Penk	IDA		Mouse	MGI:MGI:7260101|PMID:6933569
Molecular Function	GO:0031628	opioid receptor binding	Penk	IDA		Mouse	MGI:MGI:7260092|PMID:35201898
Cellular Component	GO:0030424	axon	Penk	IDA		Rat	PMID:23912034|RGD:10003097
Cellular Component	GO:0043679	axon terminus	Penk	IDA		Rat	PMID:20686827|RGD:10003148
Cellular Component	GO:0070852	cell body fiber	Penk	IDA		Rat	PMID:20686827|RGD:10003148
Cellular Component	GO:0030425	dendrite	Penk	IDA		Rat	PMID:20686827|RGD:10003148
Cellular Component	GO:0043025	neuronal cell body	Penk	IDA		Rat	PMID:2695900|RGD:9999369
Cellular Component	GO:0099013	neuronal dense core vesicle lumen	Penk	IDA		Rat	PMID:8847409|RGD:13702175
Cellular Component	GO:0043204	perikaryon	Penk	IDA		Rat	PMID:23912034|RGD:10003097
Cellular Component	GO:0032280	symmetric synapse	Penk	IDA		Rat	PMID:20686827|RGD:10003148
Cellular Component	GO:0034592	synaptic vesicle lumen	Penk	IDA		Rat	PMID:8847409|RGD:13702175
Biological Process	GO:0002118	aggressive behavior	Penk	IMP	MGI:MGI:1857305	Mouse	PMID:8849726
Biological Process	GO:0007568	aging	Penk	IEP		Rat	PMID:8089851|RGD:9999372
Biological Process	GO:0001662	behavioral fear response	Penk	IMP	MGI:MGI:2388020	Mouse	PMID:11172058
Biological Process	GO:0071320	cellular response to cAMP	Penk	IEP		Rat	PMID:9826786|RGD:10003022
Biological Process	GO:0034599	cellular response to oxidative stress	Penk	IEP		Rat	PMID:11595755|RGD:9999371
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Penk	IEP		Rat	PMID:8584038|RGD:10003035
Biological Process	GO:0098586	cellular response to virus	Penk	IEP		Rat	PMID:8411369|RGD:10003023
Biological Process	GO:0071305	cellular response to vitamin D	Penk	IEP		Rat	PMID:8584038|RGD:10003035
Biological Process	GO:0051867	general adaptation syndrome, behavioral process	Penk	IEP		Rat	PMID:23665402|RGD:10003151
Biological Process	GO:0014009	glial cell proliferation	Penk	IEP		Rat	PMID:9221949|RGD:9999373
Biological Process	GO:0007626	locomotory behavior	Penk	IMP	MGI:MGI:1857305	Mouse	PMID:8849726
Biological Process	GO:0035641	locomotory exploration behavior	Penk	IMP		Rat	PMID:23368426|RGD:10040949
Biological Process	GO:0001649	osteoblast differentiation	Penk	IEP		Rat	PMID:8584038|RGD:10003035
Biological Process	GO:2000987	positive regulation of behavioral fear response	Penk	IMP		Rat	PMID:23368426|RGD:10040949
Biological Process	GO:1900452	regulation of long-term synaptic depression	Penk	IDA		Mouse	MGI:MGI:7260092|PMID:35201898
Biological Process	GO:0009617	response to bacterium	Penk	IEP		Mouse	PMID:23012479
Biological Process	GO:0051592	response to calcium ion	Penk	IEP		Rat	PMID:10426412|RGD:10002788
Biological Process	GO:0071871	response to epinephrine	Penk	IEP		Rat	PMID:8784263|RGD:10003024
Biological Process	GO:0032355	response to estradiol	Penk	IEP		Rat	PMID:12503826|RGD:9999374
Biological Process	GO:0045471	response to ethanol	Penk	IEP		Rat	PMID:20184566|RGD:10003121
Biological Process	GO:0001666	response to hypoxia	Penk	IEP		Rat	PMID:22200548|RGD:10003120
Biological Process	GO:0032496	response to lipopolysaccharide	Penk	IEP		Rat	PMID:8784263|RGD:10003024
Biological Process	GO:0043278	response to morphine	Penk	IEP		Rat	PMID:23300784|RGD:10003095
Biological Process	GO:0035094	response to nicotine	Penk	IEP		Rat	PMID:25086310|RGD:10003145
Biological Process	GO:0009314	response to radiation	Penk	IEP		Rat	PMID:8584889|RGD:9999370
Biological Process	GO:0009636	response to toxic substance	Penk	IEP		Rat	PMID:23410195|RGD:10003038
Biological Process	GO:0019233	sensory perception of pain	Penk	IMP	MGI:MGI:1857305	Mouse	PMID:8849726
Biological Process	GO:0001964	startle response	Penk	IMP	MGI:MGI:1857305	Mouse	PMID:8849726
Biological Process	GO:0099538	synaptic signaling via neuropeptide	Penk	EXP		Rat	PMID:355888|RGD:13702392
Biological Process	GO:0099538	synaptic signaling via neuropeptide	Penk	IMP		Rat	PMID:355888|RGD:13702392

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern