Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PEX2
  • Mouse genes Pex2
  • Rat genes Pex2
  • Zfish genes pex2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pex2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PEX2	IPI	UniProtKB:O60683	Human	PMID:10837480
Molecular Function	GO:0005515	protein binding	PEX2	IPI	UniProtKB:P40855	Human	PMID:11590176
Molecular Function	GO:0005515	protein binding	PEX2	IPI	UniProtKB:P40855	Human	PMID:20531392
Molecular Function	GO:0061630	ubiquitin protein ligase activity	PEX2	IDA		Human	PMID:27597759
Molecular Function	GO:0061630	ubiquitin protein ligase activity	PEX2	IDA		Human	PMID:34903883
Cellular Component	GO:0016593	Cdc73/Paf1 complex	PEX2	IDA		Human	PMID:18987311
Cellular Component	GO:0016020	membrane	PEX2	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Pex2	IDA		Rat	PMID:10348921|RGD:1625412
Cellular Component	GO:0005778	peroxisomal membrane	PEX2	IDA		Human	PMID:12751901
Cellular Component	GO:0005778	peroxisomal membrane	PEX2	IMP		Human	PMID:12751901
Cellular Component	GO:0005778	peroxisomal membrane	PEX2	HDA		Human	PMID:21525035
Cellular Component	GO:0005778	peroxisomal membrane	Pex2	IDA		Rat	PMID:10348921|RGD:1625412
Cellular Component	GO:0005778	peroxisomal membrane	Pex2	IDA		Rat	PMID:14561759|RGD:1580664
Cellular Component	GO:0005778	peroxisomal membrane	Pex2	IDA		Rat	PMID:8035823|RGD:61727
Cellular Component	GO:0005777	peroxisome	Pex2	IDA		Rat	PMID:14561759|RGD:1580664
Biological Process	GO:0006699	bile acid biosynthetic process	Pex2	IMP	MGI:MGI:2180128	Mouse	PMID:14673138
Biological Process	GO:0034614	cellular response to reactive oxygen species	PEX2	IDA		Human	PMID:26344566
Biological Process	GO:0042632	cholesterol homeostasis	Pex2	IMP	MGI:MGI:2180128	Mouse	PMID:14673138
Biological Process	GO:0006635	fatty acid beta-oxidation	PEX2	IMP		Human	PMID:10528859
Biological Process	GO:0006635	fatty acid beta-oxidation	PEX2	IMP		Human	PMID:9765053
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	PEX2	IMP		Human	PMID:18987311
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	PEX2	IMP		Human	PMID:18987311
Biological Process	GO:0007399	nervous system development	Pex2	IMP	MGI:MGI:2180128	Mouse	PMID:12746876
Biological Process	GO:0001764	neuron migration	Pex2	IMP	MGI:MGI:2180128	Mouse	PMID:12746876
Biological Process	GO:0007031	peroxisome organization	PEX2	IMP		Human	PMID:1546315
Biological Process	GO:0007031	peroxisome organization	PEX2	IMP		Human	PMID:9765053
Biological Process	GO:0007031	peroxisome organization	Pex2	IMP		Mouse	MGI:MGI:1101553|PMID:9382874
Biological Process	GO:0007031	peroxisome organization	pex2	IMP	ZFIN:ZDB-GENO-220715-5	Zfish	PMID:34016526
Biological Process	GO:0007031	peroxisome organization	pex2	IMP	ZFIN:ZDB-GENO-220715-6	Zfish	PMID:34016526
Biological Process	GO:0000425	pexophagy	PEX2	IDA		Human	PMID:26344566
Biological Process	GO:0000425	pexophagy	PEX2	IDA		Human	PMID:27597759
Biological Process	GO:0031648	protein destabilization	PEX2	IMP		Human	PMID:18987311
Biological Process	GO:0016558	protein import into peroxisome matrix	PEX2	IMP		Human	PMID:10528859
Biological Process	GO:0016562	protein import into peroxisome matrix, receptor recycling	PEX2	IDA		Human	PMID:24662292
Biological Process	GO:0006513	protein monoubiquitination	PEX2	IDA		Human	PMID:27597759
Biological Process	GO:0045540	regulation of cholesterol biosynthetic process	Pex2	IMP	MGI:MGI:2180128	Mouse	PMID:14673138
Biological Process	GO:1990928	response to amino acid starvation	PEX2	IDA		Human	PMID:27597759
Biological Process	GO:0000038	very long-chain fatty acid metabolic process	PEX2	IMP		Human	PMID:9765053

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern