Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PF4,PF4V1
  • Mouse genes Pf4
  • Rat genes Pf4
  • Zfish genes cxcl8b.3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048248	CXCR3 chemokine receptor binding	PF4	IDA		Human	PMID:12782716
Molecular Function	GO:0008201	heparin binding	PF4	IDA		Human	PMID:9531587
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P02749	Human	PMID:19805618
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:O00585	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:O14625	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:O15444	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:O95715	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P02778	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P10145	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P13500	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P13501	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P13501:PRO_0000005175	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P19875	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P47992	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P48061	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P51671	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P78556	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:P80162	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:Q07325	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:Q6UXB2	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:Q92583	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:Q99616	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:Q9NRJ3	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4	IPI	UniProtKB:Q9Y258	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4V1	IPI	UniProtKB:O00585	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4V1	IPI	UniProtKB:O14625	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4V1	IPI	UniProtKB:O15444	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4V1	IPI	UniProtKB:P47992	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	PF4V1	IPI	UniProtKB:P48061	Human	PMID:28381538
Cellular Component	GO:0062023	collagen-containing extracellular matrix	PF4	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Pf4	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0005737	cytoplasm	PF4	IDA		Human	PMID:23245326
Cellular Component	GO:0031091	platelet alpha granule	Pf4	IDA		Rat	PMID:2379543|RGD:2316766
Cellular Component	GO:0032991	protein-containing complex	Pf4	IDA		Rat	PMID:12676928|RGD:1582508
Cellular Component	GO:0031982	vesicle	Pf4	IDA		Rat	PMID:2379543|RGD:2316766
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PF4	IDA		Human	PMID:12782716
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PF4	IDA		Human	PMID:23245326
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	Pf4	IMP		Mouse	MGI:MGI:5897546|PMID:23245326
Biological Process	GO:0019221	cytokine-mediated signaling pathway	PF4	IDA		Human	PMID:12041672
Biological Process	GO:0042832	defense response to protozoan	PF4	IDA		Human	PMID:23245326
Biological Process	GO:0042832	defense response to protozoan	Pf4	IMP		Mouse	MGI:MGI:5897546|PMID:23245326
Biological Process	GO:0006955	immune response	Pf4	IDA		Rat	PMID:12383857|RGD:724612
Biological Process	GO:0051873	killing by host of symbiont cells	PF4	IDA		Human	PMID:23245326
Biological Process	GO:0030595	leukocyte chemotaxis	PF4	IDA		Human	PMID:6945600
Biological Process	GO:0016525	negative regulation of angiogenesis	PF4	IDA		Human	PMID:1688470
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	PF4	IDA		Human	PMID:10666185
Biological Process	GO:0045653	negative regulation of megakaryocyte differentiation	PF4	IDA		Human	PMID:2140694
Biological Process	GO:0045347	negative regulation of MHC class II biosynthetic process	PF4	IDA		Human	PMID:10666185
Biological Process	GO:0030316	osteoclast differentiation	Pf4	HEP		Rat	PMID:16304045|RGD:151665775
Biological Process	GO:0030168	platelet activation	PF4	IDA		Human	PMID:11685038
Biological Process	GO:0010628	positive regulation of gene expression	PF4	IDA		Human	PMID:10666185
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	PF4	IDA		Human	PMID:17244792
Biological Process	GO:0045651	positive regulation of macrophage differentiation	PF4	IDA		Human	PMID:10666185
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PF4	IDA		Human	PMID:12782716
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	PF4	IDA		Human	PMID:10666185
Biological Process	GO:0065003	protein-containing complex assembly	Pf4	IPI	RGD:3088|RGD:2075|RGD:708488|RGD:68322|ChEBI:35156|ChEBI:26020	Rat	PMID:12676928|RGD:1582508
Biological Process	GO:0042127	regulation of cell population proliferation	PF4	IDA		Human	PMID:12782716

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern