Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PFKFB1
  • Mouse genes Pfkfb1
  • Rat genes Pfkfb1
  • Zfish genes pfkfb1,si:dkey-96f10.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pfkfb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003873	6-phosphofructo-2-kinase activity	Pfkfb1	IDA		Rat	PMID:7619077|RGD:2302679
Molecular Function	GO:0005524	ATP binding	Pfkfb1	IDA		Rat	PMID:7619077|RGD:2302679
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	PFKFB1	IDA		Human	PMID:2837207
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Pfkfb1	IGI	MGI:MGI:97592	Mouse	PMID:16155866
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Pfkfb1	IDA		Rat	PMID:7619077|RGD:2302679
Molecular Function	GO:0070095	fructose-6-phosphate binding	Pfkfb1	IDA		Rat	PMID:7619077|RGD:2302679
Molecular Function	GO:0042802	identical protein binding	PFKFB1	IPI	UniProtKB:P16118	Human	PMID:12379646
Molecular Function	GO:0042802	identical protein binding	PFKFB1	IPI	UniProtKB:P16118	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	PFKFB1	IPI	UniProtKB:P16118	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	Pfkfb1	IPI	UniProtKB:P07953	Rat	PMID:11522786|RGD:2302683
Molecular Function	GO:0042802	identical protein binding	Pfkfb1	IPI	UniProtKB:P07953	Rat	PMID:22668829|RGD:8554823
Molecular Function	GO:0042802	identical protein binding	Pfkfb1	IDA		Rat	PMID:7619077|RGD:2302679
Molecular Function	GO:0042802	identical protein binding	Pfkfb1	IPI	UniProtKB:P07953	Rat	PMID:8634242|RGD:8553805
Molecular Function	GO:0019900	kinase binding	Pfkfb1	IPI	RGD:69130	Rat	PMID:11522786|RGD:2302683
Molecular Function	GO:0019210	kinase inhibitor activity	Pfkfb1	IGI	MGI:MGI:97592	Mouse	PMID:16155866
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:P09467	Human	PMID:10222032
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:P35557	Human	PMID:11522786
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:P0C7X2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:P27815-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:Q16875	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:Q16877	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:Q2TAL6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:Q58EX7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:Q6S9Z5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:Q8N554	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:Q8N720	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PFKFB1	IPI	UniProtKB:Q9H079	Human	PMID:32296183
Cellular Component	GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	PFKFB1	IDA		Human	PMID:12379646
Cellular Component	GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	Pfkfb1	IDA		Rat	PMID:7619077|RGD:2302679
Biological Process	GO:0031100	animal organ regeneration	Pfkfb1	IEP		Rat	PMID:1315037|RGD:2302677
Biological Process	GO:0046835	carbohydrate phosphorylation	Pfkfb1	IDA		Rat	PMID:7619077|RGD:2302679
Biological Process	GO:0006003	fructose 2,6-bisphosphate metabolic process	PFKFB1	IDA		Human	PMID:2837207
Biological Process	GO:1904539	negative regulation of glycolytic process through fructose-6-phosphate	Pfkfb1	IMP		Mouse	PMID:15331593
Biological Process	GO:1904539	negative regulation of glycolytic process through fructose-6-phosphate	Pfkfb1	IGI	MGI:MGI:97592	Mouse	PMID:16155866
Biological Process	GO:0033133	positive regulation of glucokinase activity	Pfkfb1	IMP		Rat	PMID:15047617|RGD:2302684
Biological Process	GO:0051591	response to cAMP	Pfkfb1	IEP		Rat	PMID:7593243|RGD:2302678
Biological Process	GO:0033762	response to glucagon	Pfkfb1	IEP		Rat	PMID:7593243|RGD:2302678
Biological Process	GO:0051384	response to glucocorticoid	Pfkfb1	IEP		Rat	PMID:7593243|RGD:2302678
Biological Process	GO:0051384	response to glucocorticoid	Pfkfb1	IEP		Rat	PMID:8131849|RGD:2302680
Biological Process	GO:0032868	response to insulin	Pfkfb1	IEP		Rat	PMID:8131849|RGD:2302680
Biological Process	GO:0042594	response to starvation	Pfkfb1	IEP		Rat	PMID:9705027|RGD:2302681

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern