Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PFN2
  • Mouse genes Pfn2
  • Rat genes Pfn2
  • Zfish genes pfn2a,pfn2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pfn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Pfn2	IDA		Rat	PMID:11027290|RGD:727303
Molecular Function	GO:0003785	actin monomer binding	PFN2	IPI	UniProtKB:P68135	Human	PMID:7758455
Molecular Function	GO:0016887	ATP hydrolysis activity	PFN2	IDA		Human	PMID:7758455
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PFN2	IDA		Human	PMID:7758455
Molecular Function	GO:0005515	protein binding	PFN2	IPI	UniProtKB:P42858	Human	PMID:15383276
Molecular Function	GO:0005515	protein binding	PFN2	IPI	UniProtKB:Q14789	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	PFN2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PFN2	IPI	UniProtKB:O08816	Human	PMID:9822597
Molecular Function	GO:0005515	protein binding	Pfn2	IPI	UniProtKB:P50552|UniProtKB:P70429	Mouse	MGI:MGI:5545940|PMID:23153535
Molecular Function	GO:0005515	protein binding	Pfn2	IPI	UniProtKB:P39053	Mouse	MGI:MGI:3621218|PMID:16319076
Molecular Function	GO:0005515	protein binding	Pfn2	IPI	PR:Q0QWG9	Mouse	PMID:11826110
Cellular Component	GO:0070062	extracellular exosome	PFN2	HDA		Human	PMID:19056867
Cellular Component	GO:0098978	glutamatergic synapse	Pfn2	IDA		Mouse	PMID:26951674
Cellular Component	GO:0098978	glutamatergic synapse	Pfn2	IMP		Mouse	PMID:26951674
Cellular Component	GO:0098978	glutamatergic synapse	Pfn2	IDA		Mouse	PMID:17541406
Cellular Component	GO:0098978	glutamatergic synapse	Pfn2	IMP		Mouse	PMID:17541406
Cellular Component	GO:0098794	postsynapse	Pfn2	IDA		Mouse	PMID:17541406
Cellular Component	GO:0098793	presynapse	Pfn2	IDA		Mouse	PMID:17541406
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Pfn2	IDA		Mouse	PMID:17541406
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	Pfn2	IDA		Mouse	PMID:26951674
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	Pfn2	IMP		Mouse	PMID:26951674
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Pfn2	IDA		Mouse	PMID:26951674
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Pfn2	IMP		Mouse	PMID:26951674
Biological Process	GO:0030837	negative regulation of actin filament polymerization	PFN2	IDA		Human	PMID:7758455
Biological Process	GO:0010633	negative regulation of epithelial cell migration	PFN2	IMP		Human	PMID:23153535
Biological Process	GO:0010633	negative regulation of epithelial cell migration	Pfn2	IMP		Mouse	MGI:MGI:5545940|PMID:23153535
Biological Process	GO:1900028	negative regulation of ruffle assembly	PFN2	IMP		Human	PMID:23153535
Biological Process	GO:1900028	negative regulation of ruffle assembly	Pfn2	IMP		Mouse	MGI:MGI:5545940|PMID:23153535
Biological Process	GO:0032233	positive regulation of actin filament bundle assembly	PFN2	IMP		Human	PMID:23153535
Biological Process	GO:0030838	positive regulation of actin filament polymerization	PFN2	IGI	UniProtKB:P07737	Human	PMID:23153535
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Pfn2	IMP	MGI:MGI:3715145	Mouse	PMID:17541406
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	PFN2	IDA		Human	PMID:7758455
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PFN2	IMP		Human	PMID:23153535
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Pfn2	IMP		Mouse	MGI:MGI:5545940|PMID:23153535
Biological Process	GO:0051496	positive regulation of stress fiber assembly	PFN2	IMP		Human	PMID:23153535
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Pfn2	IMP		Mouse	MGI:MGI:5545940|PMID:23153535
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Pfn2	IDA		Mouse	PMID:17541406
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Pfn2	IMP		Mouse	PMID:17541406
Biological Process	GO:0050821	protein stabilization	PFN2	IDA		Human	PMID:18573880
Biological Process	GO:0030833	regulation of actin filament polymerization	Pfn2	IDA		Rat	PMID:11027290|RGD:727303
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Pfn2	IMP	MGI:MGI:3715145	Mouse	PMID:17541406

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern